Endothelial Protease Activated Receptor 1 (PAR1) Signalling Is Required for Lymphocyte Transmigration across Brain Microvascular Endothelial Cells

Endothelial Protease Activated Receptor 1 (PAR1) Signalling Is Required for Lymphocyte Transmigration across Brain Microvascular Endothelial Cells

Lymphocyte transendothelial migration (TEM) relies on ICAM-1 engagement on the luminal surface of the endothelial cells (ECs). In blood–brain barrier (BBB) ECs, ICAM-1 triggers TEM signalling, including through JNK MAP kinase and AMP-activated protein kinase (AMPK), which lead to the phosphorylation...

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Bibliographic Details
Main Authors:	Silvia Dragoni, Anna Papageorgiou, Caroline Araiz, John Greenwood, Patric Turowski
Format:	Article
Language:	English
Published:	MDPI AG 2020-12-01
Series:	Cells
Subjects:	lymphocyte transendothelial migration blood–brain barrier protease-activated receptor 1 AMP-activated protein kinase endothelial nitric oxide synthase
Online Access:	https://www.mdpi.com/2073-4409/9/12/2723

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