Natural Compound-Derived Cytochrome bc1 Complex Inhibitors as Antifungal Agents
The high incidence of fungal pathogens has become a global issue for crop protection. A promising strategy to control fungal plant infections is based on the use of nature-inspired compounds. The cytochrome bc1 complex is an essential component of the cellular respiratory chain and is one of the mos...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-10-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/25/19/4582 |
| _version_ | 1827704798933155840 |
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| author | Loana Musso Andrea Fabbrini Sabrina Dallavalle |
| author_facet | Loana Musso Andrea Fabbrini Sabrina Dallavalle |
| author_sort | Loana Musso |
| collection | DOAJ |
| description | The high incidence of fungal pathogens has become a global issue for crop protection. A promising strategy to control fungal plant infections is based on the use of nature-inspired compounds. The cytochrome bc1 complex is an essential component of the cellular respiratory chain and is one of the most important fungicidal targets. Natural products have played a crucial role in the discovery of cytochrome bc1 inhibitors, as proven by the development of strobilurins, one of the most important classes of crop-protection agents, over the past two decades. In this review, we summarize advances in the exploration of natural product scaffolds for the design and development of new bc1 complex inhibitors. Particular emphasis is given to molecular modeling-based approaches and structure–activity relationship (SAR) studies performed to improve the stability and increase the potency of natural precursors. The collected results highlight the versatility of natural compounds and provide an insight into the potential development of nature-inspired derivatives as antifungal agents. |
| first_indexed | 2024-03-10T15:48:17Z |
| format | Article |
| id | doaj.art-ebcd18068e9d4b3fb705496bf26dba5d |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T15:48:17Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-ebcd18068e9d4b3fb705496bf26dba5d2023-11-20T16:19:26ZengMDPI AGMolecules1420-30492020-10-012519458210.3390/molecules25194582Natural Compound-Derived Cytochrome bc1 Complex Inhibitors as Antifungal AgentsLoana Musso0Andrea Fabbrini1Sabrina Dallavalle2Department of Food, Environmental and Nutritional Sciences (DeFENS), Division of Chemical and Biomolecular Sciences, Università degli Studi di Milano, Via Celoria 2, 20133 Milan, ItalyDepartment of Food, Environmental and Nutritional Sciences (DeFENS), Division of Chemical and Biomolecular Sciences, Università degli Studi di Milano, Via Celoria 2, 20133 Milan, ItalyDepartment of Food, Environmental and Nutritional Sciences (DeFENS), Division of Chemical and Biomolecular Sciences, Università degli Studi di Milano, Via Celoria 2, 20133 Milan, ItalyThe high incidence of fungal pathogens has become a global issue for crop protection. A promising strategy to control fungal plant infections is based on the use of nature-inspired compounds. The cytochrome bc1 complex is an essential component of the cellular respiratory chain and is one of the most important fungicidal targets. Natural products have played a crucial role in the discovery of cytochrome bc1 inhibitors, as proven by the development of strobilurins, one of the most important classes of crop-protection agents, over the past two decades. In this review, we summarize advances in the exploration of natural product scaffolds for the design and development of new bc1 complex inhibitors. Particular emphasis is given to molecular modeling-based approaches and structure–activity relationship (SAR) studies performed to improve the stability and increase the potency of natural precursors. The collected results highlight the versatility of natural compounds and provide an insight into the potential development of nature-inspired derivatives as antifungal agents.https://www.mdpi.com/1420-3049/25/19/4582natural compoundscytochrome bc1 complexantifungals(E)-β-methoxyacrylatestrobilurins |
| spellingShingle | Loana Musso Andrea Fabbrini Sabrina Dallavalle Natural Compound-Derived Cytochrome bc1 Complex Inhibitors as Antifungal Agents Molecules natural compounds cytochrome bc1 complex antifungals (E)-β-methoxyacrylate strobilurins |
| title | Natural Compound-Derived Cytochrome bc1 Complex Inhibitors as Antifungal Agents |
| title_full | Natural Compound-Derived Cytochrome bc1 Complex Inhibitors as Antifungal Agents |
| title_fullStr | Natural Compound-Derived Cytochrome bc1 Complex Inhibitors as Antifungal Agents |
| title_full_unstemmed | Natural Compound-Derived Cytochrome bc1 Complex Inhibitors as Antifungal Agents |
| title_short | Natural Compound-Derived Cytochrome bc1 Complex Inhibitors as Antifungal Agents |
| title_sort | natural compound derived cytochrome bc1 complex inhibitors as antifungal agents |
| topic | natural compounds cytochrome bc1 complex antifungals (E)-β-methoxyacrylate strobilurins |
| url | https://www.mdpi.com/1420-3049/25/19/4582 |
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