IFN-γ lowers tumor growth by increasing glycolysis and lactate production in a nitric oxide-dependent manner: implications for cancer immunotherapy

IFN-γ lowers tumor growth by increasing glycolysis and lactate production in a nitric oxide-dependent manner: implications for cancer immunotherapy

IntroductionInterferon-gamma (IFN-γ), the sole member of the type-II interferon family, is well known to protect the host from infectious diseases as well as mount anti-tumor responses. The amounts of IFN-γ in the tumor microenvironment determine the host responses against tumors; however, several t...

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Bibliographic Details
Main Authors: Avik Chattopadhyay, Sirisha Jagdish, Aagosh Kishor Karhale, Nikita S. Ramteke, Arsha Zaib, Dipankar Nandi
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Immunology
Subjects:
interferon-gamma
nitric oxide
lactate
HIF-1 alpha
tumor
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1282653/full

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