IFN-γ lowers tumor growth by increasing glycolysis and lactate production in a nitric oxide-dependent manner: implications for cancer immunotherapy
IntroductionInterferon-gamma (IFN-γ), the sole member of the type-II interferon family, is well known to protect the host from infectious diseases as well as mount anti-tumor responses. The amounts of IFN-γ in the tumor microenvironment determine the host responses against tumors; however, several t...
Main Authors: | Avik Chattopadhyay, Sirisha Jagdish, Aagosh Kishor Karhale, Nikita S. Ramteke, Arsha Zaib, Dipankar Nandi |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2023-10-01
|
Series: | Frontiers in Immunology |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1282653/full |
Similar Items
-
IFNλ is a potent anti‐influenza therapeutic without the inflammatory side effects of IFNα treatment
by: Sophia Davidson, et al.
Published: (2016-09-01) -
Contributions of Ubiquitin and Ubiquitination to Flaviviral Antagonism of Type I IFN
by: Erika Hay-McCullough, et al.
Published: (2021-04-01) -
Alterations in the Expression of IFN Lambda, IFN Gamma and Toll-like Receptors in Severe COVID-19 Patients
by: Leonardo Sorrentino, et al.
Published: (2023-03-01) -
Pathways of IFN-alpha Activation in Patients with Cervical Intraepithelial Neoplasia (CIN)
by: Nelson Ranieri Tirone, et al.
Published: (2021-11-01) -
Significance of the interferon (IFN) in the therapy
by: Sabina Mahmutović, et al.
Published: (2004-11-01)