Patterns of primary glomerular diseases among adults in the western region of Saudi Arabia
The frequency of primary glomerular diseases is variable from one part of the world to the other. Data published from Saudi Arabia has shown wide range of variation in the different regions of the country. This study reports the frequency of primary glomerulonephritis (GN) in adults in the Western r...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2009-01-01
|
| Series: | Saudi Journal of Kidney Diseases and Transplantation |
| Subjects: | |
| Online Access: | http://www.sjkdt.org/article.asp?issn=1319-2442;year=2009;volume=20;issue=2;spage=295;epage=299;aulast=Jalalah |
| _version_ | 1829142179222650880 |
|---|---|
| author | Jalalah Sawsan |
| author_facet | Jalalah Sawsan |
| author_sort | Jalalah Sawsan |
| collection | DOAJ |
| description | The frequency of primary glomerular diseases is variable from one part of the world to the other. Data published from Saudi Arabia has shown wide range of variation in the different regions of the country. This study reports the frequency of primary glomerulonephritis (GN) in adults in the Western region of Saudi Arabia. The study is based on retrospective evalua-tion of archived renal biopsy in the period of 18 years (1989-2007). The 296 selected cases of primary GN were studied by light, immunofluorescence, and electron microscopy. The patients age range between 17-76 years. Results show that the most frequent primary GN is membranous GN (MGN) constituting <i> 25.7%, </i> followed by focal segmental glomerulosclerosis (FSGSC) at 21.3%. Less frequent GN are immunoglobulins A nephropathy (IgAN) representing 17.6%, membrano-proliferative GN (MPGN) 11.5%, immunoglobulin M nephropathy (IgMN) <i> 7.8%, </i> minimal change disease (MCD) 5.4% and mesangioprolifertive GN (MesPGN) 4.7%. Other GN which are rarely encountered in this study are fibrillary GN (FGN) (3%), postinfectious GN (PIGN) (2%), Alport syndrome (AS) <i> (0.7%) </i> and membranoproliferative GN type II or dense deposit disease (DDD) (0.3%). In conclusion this study demonstrates that MGN is the most common primary GN encountered in the studied cases, the second more frequent is FSGSC. This result is in contrast to previous reports from Saudi Arabia where MGN is reported with low frequency and FSGSC is reported the most common primary GN. |
| first_indexed | 2024-12-14T20:26:38Z |
| format | Article |
| id | doaj.art-ebd09b66cbd04c6982b3f7b42fdea4f7 |
| institution | Directory Open Access Journal |
| issn | 1319-2442 |
| language | English |
| last_indexed | 2024-12-14T20:26:38Z |
| publishDate | 2009-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Saudi Journal of Kidney Diseases and Transplantation |
| spelling | doaj.art-ebd09b66cbd04c6982b3f7b42fdea4f72022-12-21T22:48:37ZengWolters Kluwer Medknow PublicationsSaudi Journal of Kidney Diseases and Transplantation1319-24422009-01-01202295299Patterns of primary glomerular diseases among adults in the western region of Saudi ArabiaJalalah SawsanThe frequency of primary glomerular diseases is variable from one part of the world to the other. Data published from Saudi Arabia has shown wide range of variation in the different regions of the country. This study reports the frequency of primary glomerulonephritis (GN) in adults in the Western region of Saudi Arabia. The study is based on retrospective evalua-tion of archived renal biopsy in the period of 18 years (1989-2007). The 296 selected cases of primary GN were studied by light, immunofluorescence, and electron microscopy. The patients age range between 17-76 years. Results show that the most frequent primary GN is membranous GN (MGN) constituting <i> 25.7%, </i> followed by focal segmental glomerulosclerosis (FSGSC) at 21.3%. Less frequent GN are immunoglobulins A nephropathy (IgAN) representing 17.6%, membrano-proliferative GN (MPGN) 11.5%, immunoglobulin M nephropathy (IgMN) <i> 7.8%, </i> minimal change disease (MCD) 5.4% and mesangioprolifertive GN (MesPGN) 4.7%. Other GN which are rarely encountered in this study are fibrillary GN (FGN) (3%), postinfectious GN (PIGN) (2%), Alport syndrome (AS) <i> (0.7%) </i> and membranoproliferative GN type II or dense deposit disease (DDD) (0.3%). In conclusion this study demonstrates that MGN is the most common primary GN encountered in the studied cases, the second more frequent is FSGSC. This result is in contrast to previous reports from Saudi Arabia where MGN is reported with low frequency and FSGSC is reported the most common primary GN.http://www.sjkdt.org/article.asp?issn=1319-2442;year=2009;volume=20;issue=2;spage=295;epage=299;aulast=JalalahPrimary Glomerular DiseaseAdultSaudi Arabia |
| spellingShingle | Jalalah Sawsan Patterns of primary glomerular diseases among adults in the western region of Saudi Arabia Saudi Journal of Kidney Diseases and Transplantation Primary Glomerular Disease Adult Saudi Arabia |
| title | Patterns of primary glomerular diseases among adults in the western region of Saudi Arabia |
| title_full | Patterns of primary glomerular diseases among adults in the western region of Saudi Arabia |
| title_fullStr | Patterns of primary glomerular diseases among adults in the western region of Saudi Arabia |
| title_full_unstemmed | Patterns of primary glomerular diseases among adults in the western region of Saudi Arabia |
| title_short | Patterns of primary glomerular diseases among adults in the western region of Saudi Arabia |
| title_sort | patterns of primary glomerular diseases among adults in the western region of saudi arabia |
| topic | Primary Glomerular Disease Adult Saudi Arabia |
| url | http://www.sjkdt.org/article.asp?issn=1319-2442;year=2009;volume=20;issue=2;spage=295;epage=299;aulast=Jalalah |
| work_keys_str_mv | AT jalalahsawsan patternsofprimaryglomerulardiseasesamongadultsinthewesternregionofsaudiarabia |