DORNASE ALFA IN RUSSIA: 15 YEARS LATER. EFFICACY OF THE DRUG IN THE BASIC TREATMENT IN CHILDREN WITH CYSTIC FIBROSIS
The 15-years practice of Pulmozyme (dornase alfa) usage showed its high efficacy and safety in cystic fibrosis treatment in children of various age, including infants. The efficacy of the drug is associate with clinical effects: strong mucolytic, anti-inflammatory and antibacterial effects. The appr...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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"Paediatrician" Publishers LLC
2012-03-01
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| Series: | Вопросы современной педиатрии |
| Subjects: | |
| Online Access: | https://vsp.spr-journal.ru/jour/article/view/133 |
| _version_ | 1826562075114078208 |
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| author | O. I. Simonova O. F. Lukina |
| author_facet | O. I. Simonova O. F. Lukina |
| author_sort | O. I. Simonova |
| collection | DOAJ |
| description | The 15-years practice of Pulmozyme (dornase alfa) usage showed its high efficacy and safety in cystic fibrosis treatment in children of various age, including infants. The efficacy of the drug is associate with clinical effects: strong mucolytic, anti-inflammatory and antibacterial effects. The appropriateness of including this into the complex of the basic therapy of cystic fibrosis in order to prevent and treat chronic bronchitis and chronic polypous pansinusitis as soon as the disease is diagnosed was confirmed in studies. Regular use of this drug results in relapse rate decrease, remission periods prolongation and maintenance of external respiration at stable level, which enable patients to live active life. The therapeutic effect of dornase alfa depends on strict compliance to directions of its usage, as this agent is a proteolytic enzyme. |
| first_indexed | 2024-03-12T03:32:19Z |
| format | Article |
| id | doaj.art-ebd199de4a744701ab521c08c3b14d0b |
| institution | Directory Open Access Journal |
| issn | 1682-5527 1682-5535 |
| language | English |
| last_indexed | 2025-03-14T09:42:18Z |
| publishDate | 2012-03-01 |
| publisher | "Paediatrician" Publishers LLC |
| record_format | Article |
| series | Вопросы современной педиатрии |
| spelling | doaj.art-ebd199de4a744701ab521c08c3b14d0b2025-03-02T11:34:03Zeng"Paediatrician" Publishers LLCВопросы современной педиатрии1682-55271682-55352012-03-0111213213910.15690/vsp.v11i2.226133DORNASE ALFA IN RUSSIA: 15 YEARS LATER. EFFICACY OF THE DRUG IN THE BASIC TREATMENT IN CHILDREN WITH CYSTIC FIBROSISO. I. Simonova0O. F. Lukina1Scientific Centre of Children Health RAMS, MoscowScientific Centre of Children Health RAMS, MoscowThe 15-years practice of Pulmozyme (dornase alfa) usage showed its high efficacy and safety in cystic fibrosis treatment in children of various age, including infants. The efficacy of the drug is associate with clinical effects: strong mucolytic, anti-inflammatory and antibacterial effects. The appropriateness of including this into the complex of the basic therapy of cystic fibrosis in order to prevent and treat chronic bronchitis and chronic polypous pansinusitis as soon as the disease is diagnosed was confirmed in studies. Regular use of this drug results in relapse rate decrease, remission periods prolongation and maintenance of external respiration at stable level, which enable patients to live active life. The therapeutic effect of dornase alfa depends on strict compliance to directions of its usage, as this agent is a proteolytic enzyme.https://vsp.spr-journal.ru/jour/article/view/133cystic fibrosisdornase alfachildrenmucostasischronic non-specific lung diseaseschronic polypous pansinusitiscysticfibrosis basic treatment |
| spellingShingle | O. I. Simonova O. F. Lukina DORNASE ALFA IN RUSSIA: 15 YEARS LATER. EFFICACY OF THE DRUG IN THE BASIC TREATMENT IN CHILDREN WITH CYSTIC FIBROSIS Вопросы современной педиатрии cystic fibrosis dornase alfa children mucostasis chronic non-specific lung diseases chronic polypous pansinusitis cystic fibrosis basic treatment |
| title | DORNASE ALFA IN RUSSIA: 15 YEARS LATER. EFFICACY OF THE DRUG IN THE BASIC TREATMENT IN CHILDREN WITH CYSTIC FIBROSIS |
| title_full | DORNASE ALFA IN RUSSIA: 15 YEARS LATER. EFFICACY OF THE DRUG IN THE BASIC TREATMENT IN CHILDREN WITH CYSTIC FIBROSIS |
| title_fullStr | DORNASE ALFA IN RUSSIA: 15 YEARS LATER. EFFICACY OF THE DRUG IN THE BASIC TREATMENT IN CHILDREN WITH CYSTIC FIBROSIS |
| title_full_unstemmed | DORNASE ALFA IN RUSSIA: 15 YEARS LATER. EFFICACY OF THE DRUG IN THE BASIC TREATMENT IN CHILDREN WITH CYSTIC FIBROSIS |
| title_short | DORNASE ALFA IN RUSSIA: 15 YEARS LATER. EFFICACY OF THE DRUG IN THE BASIC TREATMENT IN CHILDREN WITH CYSTIC FIBROSIS |
| title_sort | dornase alfa in russia 15 years later efficacy of the drug in the basic treatment in children with cystic fibrosis |
| topic | cystic fibrosis dornase alfa children mucostasis chronic non-specific lung diseases chronic polypous pansinusitis cystic fibrosis basic treatment |
| url | https://vsp.spr-journal.ru/jour/article/view/133 |
| work_keys_str_mv | AT oisimonova dornasealfainrussia15yearslaterefficacyofthedruginthebasictreatmentinchildrenwithcysticfibrosis AT oflukina dornasealfainrussia15yearslaterefficacyofthedruginthebasictreatmentinchildrenwithcysticfibrosis |