Hsf1 activation inhibits rapamycin resistance and TOR signaling in yeast revealed by combined proteomic and genetic analysis.

Hsf1 activation inhibits rapamycin resistance and TOR signaling in yeast revealed by combined proteomic and genetic analysis.

TOR kinases integrate environmental and nutritional signals to regulate cell growth in eukaryotic organisms. Here, we describe results from a study combining quantitative proteomics and comparative expression analysis in the budding yeast, S. cerevisiae, to gain insights into TOR function and regula...

Full description

Bibliographic Details
Main Authors:	Sricharan Bandhakavi, Hongwei Xie, Brennon O'Callaghan, Hiroshi Sakurai, Do-Hyung Kim, Timothy J Griffin
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2008-02-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC2225505?pdf=render

Similar Items

A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans
by: Lenka Halova, et al.
Published: (2021-04-01)

On the Discovery of TOR As the Target of Rapamycin.
by: Joseph Heitman
Published: (2015-01-01)

Cyclopamine and Rapamycin Synergistically Inhibit mTOR Signalling in Mouse Hepatocytes, Revealing an Interaction of Hedgehog and mTor Signalling in the Liver
by: Luise Spormann, et al.
Published: (2020-07-01)

Mechanistic Target of Rapamycin (mTOR) in the Cancer Setting
by: James T. Murray, et al.
Published: (2018-05-01)

Defining the Essential Function of Yeast Hsf1 Reveals a Compact Transcriptional Program for Maintaining Eukaryotic Proteostasis
by: Solís, Eric J., et al.
Published: (2018)

Mammalian Target of Rapamycin (mTOR) Pathways in Neurological Diseases
by: Michael Wong
Published: (2014-04-01)

Advances in the mTOR signaling pathway and its inhibitor rapamycin in epilepsy
by: Wei Zhao, et al.
Published: (2023-06-01)

FERONIA functions through Target of Rapamycin (TOR) to negatively regulate autophagy
by: Ping Wang, et al.
Published: (2022-08-01)

Rapamycin and mTOR: a serendipitous discovery and implications for breast cancer
by: Belinda Seto
Published: (2012-12-01)

Genome-Wide Characterization and Expression of the <i>Hsf</i> Gene Family in <i>Salvia miltiorrhiza</i> (Danshen) and the Potential Thermotolerance of <i>SmHsf1</i> and <i>SmHsf7</i> in Yeast
by: Renjun Qu, et al.
Published: (2023-05-01)

Tomato FK506 Binding Protein 12KD (FKBP12) mediates the interaction between rapamycin and Target of Rapamycin (TOR)
by: Fangjie Xiong, et al.
Published: (2016-11-01)

HSF1 protects cells from cadmium toxicity by governing proteome integrity
by: Yuchun Zhang, et al.
Published: (2023-11-01)

HSF-1: Guardian of the Proteome Through Integration of Longevity Signals to the Proteostatic Network
by: Maria I. Lazaro-Pena, et al.
Published: (2022-07-01)

mTOR is essential for the proteotoxic stress response, HSF1 activation and heat shock protein synthesis.
by: Shiuh-Dih Chou, et al.
Published: (2012-01-01)

Rapamycin Attenuates Splenomegaly in both Intrahepatic and Prehepatic Portal Hypertensive Rats by Blocking mTOR Signaling Pathway.
by: Yunyang Chen, et al.
Published: (2016-01-01)

Target of Rapamycin (TOR) Negatively Regulates Ethylene Signals in <i>Arabidopsis</i>
by: Fengping Zhuo, et al.
Published: (2020-04-01)

The Plant Target of Rapamycin: A Conduc TOR of Nutrition and Metabolism in Photosynthetic Organisms
by: Camille Ingargiola, et al.
Published: (2020-10-01)

Rapamycin directly activates lysosomal mucolipin TRP channels independent of mTOR.
by: Xiaoli Zhang, et al.
Published: (2019-05-01)

Structure of the human mTOR Complex I and its implications for rapamycin inhibition
by: Yip, Calvin K., et al.
Published: (2012)

mTOR Mysteries: Nuances and Questions About the Mechanistic Target of Rapamycin in Neurodegeneration
by: Nicholas G. Norwitz, et al.
Published: (2020-07-01)

Regulation of gene expression in hepatic cells by the mammalian Target of Rapamycin (mTOR).
by: Rosa H Jimenez, et al.
Published: (2010-02-01)

Sugar metabolism and the plant Target Of Rapamycin kinase: a sweet operaTOR?
by: Thomas eDobrenel, et al.
Published: (2013-04-01)

Phosphorylated Mammalian Target of Rapamycin p-mTOR Is a Favorable Prognostic Factor than mTOR in Gastric Cancer.
by: Guo-Dong Cao, et al.
Published: (2016-01-01)

In Silico Strategy for Targeting the mTOR Kinase at Rapamycin Binding Site by Small Molecules
by: Serena Vittorio, et al.
Published: (2021-02-01)

Rapamycin Exacerbates Staphylococcus aureus Pneumonia by Inhibiting mTOR-RPS6 in Macrophages
by: Yu FY, et al.
Published: (2023-11-01)

Mammalian Target of Rapamycin (mTOR) Signaling at the Crossroad of Muscle Fiber Fate in Sarcopenia
by: Giuseppe Sirago, et al.
Published: (2022-11-01)

PREDICTION OF THE COURSE OF OSTEOARTHROSIS FROM mTOR (MAMMALIAN TARGET OF RAPAMYCIN) GENE EXPRESSION
by: E V Chetina, et al.
Published: (2012-02-01)

Involvement of Mechanistic Target of Rapamycin (mTOR) in Valine Orexigenic Effects in Rainbow Trout
by: Sara Comesaña, et al.
Published: (2022-01-01)

Target of Rapamycin (TOR) Regulates the Expression of lncRNAs in Response to Abiotic Stresses in Cotton
by: Yun Song, et al.
Published: (2019-01-01)

Comparing the Effects of the mTOR Inhibitors Azithromycin and Rapamycin on In Vitro Expanded Regulatory T Cells
by: Marcus Bergström, et al.
Published: (2019-12-01)

Effects of rapamycin on life span and on expression of TOR and S6K in Brachionus calyciflorus (Rotifera)
by: Xu, H, et al.
Published: (2017-05-01)

Longitudinal imaging studies of tumor microenvironment in mice treated with the mTOR inhibitor rapamycin.
by: Keita Saito, et al.
Published: (2012-01-01)

Targeting mTOR with MLN0128 Overcomes Rapamycin and Chemoresistant Primary Effusion Lymphoma
by: Carolina Caro-Vegas, et al.
Published: (2019-02-01)

Propionate promotes gluconeogenesis by regulating mechanistic target of rapamycin (mTOR) pathway in calf hepatocytes
by: Guo Yan Wang, et al.
Published: (2023-12-01)

Immunomodulatory and Antiaging Mechanisms of Resveratrol, Rapamycin, and Metformin: Focus on mTOR and AMPK Signaling Networks
by: Vincenzo Sorrenti, et al.
Published: (2022-07-01)

Emerging Roles for Mammalian Target of Rapamycin (mTOR) Complexes in Bladder Cancer Progression and Therapy
by: Jianya Huan, et al.
Published: (2022-03-01)

Mechanistic target of rapamycin (mTOR): a potential new therapeutic target for rheumatoid arthritis
by: Fen Zhang, et al.
Published: (2023-10-01)

Multifaceted role of mTOR (mammalian target of rapamycin) signaling pathway in human health and disease
by: Vivek Panwar, et al.
Published: (2023-10-01)

Selective ATP-Competitive Inhibitors of TOR Suppress Rapamycin-Insensitive Function of TORC2 in S. cerevisiae
by: Liu, Qingsong, et al.
Published: (2015)

Targeted inhibition of mammalian target of rapamycin (mTOR) enhances radiosensitivity in pancreatic carcinoma cells
by: Dai ZJ, et al.
Published: (2013-03-01)