Evaluation of Discrimination Indices Validity for Screening of β-Thalassemia Trait
<div><p><strong><em>Background and Objectives:</em></strong><strong> </strong>β-thalassemia trait (β-TT) and iron deficiency anemia (IDA) are the most common forms of microcytic anemia. Sc...
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| Format: | Article |
| Language: | fas |
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Qom University of Medical Sciences
2012-05-01
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| Series: | Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum |
| Online Access: | http://journal.muq.ac.ir/en/index.php/jmuqen/article/view/92 |
| Summary: | <div><p><strong><em>Background and Objectives:</em></strong><strong> </strong>β-thalassemia trait (β-TT) and iron deficiency anemia (IDA) are the most common forms of microcytic anemia. Screening of β-thalassemia trait is important for medical counseling before marriage and preventing β-thalassemia major birth results. The most common problem in screening b-TT is differentiating it from IDA. The aim of this study was to define the sensitivity, specificity, and predictive values of some discrimination indices for screening of β-TT in a sample of such patients.</p><p><strong><em>Methods:</em></strong><strong> </strong>A total of 82 patients with microcytic anemia (MCV&lt; 80 fl) were selected from Namazi Hospital, Shiraz, Iran, and 9 discrimination indices were calculated for them. The patients were divided intotwo groups: 42 patients with β-TT and 40 patients with IDA. The sensitivity, specificity, positive and negative predictive values and Youden<sup>,</sup>s index of each discrimination index were calculated for screening β-TT.<strong><em></em></strong></p><p><strong><em>Results:</em></strong> None of the discrimination indices showed 100% of sensitivity and specificity. But the Shin and Lal index, RDW index and RBC count showed the highest and valuable value for screening β-TT.<strong><em></em></strong></p><p><strong><em>Conclusion:</em></strong><strong> </strong>Some discrimination indices like Shin and Lal index, RDW index and RBC index are valuable indices in screening β-TT.<strong><em></em></strong></p></div> |
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| ISSN: | 1735-7799 2008-1375 |