The mechanism of action of different generations of EGFR-inhibitors in malignant lung tumors. Literature review and data synthesis
Knowledge of the molecular characteristics of the progression of non-small cell lung tumors currently provides the patient with the best treatment options. One of the most well-known and studied genetic abnormalities is a mutation in the EGFR gene, which makes the tumor sensitive to therapy with tyr...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
IP Habib O.N.
2022-11-01
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| Series: | Современная онкология |
| Subjects: | |
| Online Access: | https://modernonco.orscience.ru/1815-1434/article/viewFile/105003/pdf |
| _version_ | 1811191310883749888 |
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| author | Ainur F. Nasretdinov Konstantin V. Menshikov Alexander V. Sultanbaev Shamil I. Musin Nadezda I. Sultanbaeva Irina A. Men'shikova |
| author_facet | Ainur F. Nasretdinov Konstantin V. Menshikov Alexander V. Sultanbaev Shamil I. Musin Nadezda I. Sultanbaeva Irina A. Men'shikova |
| author_sort | Ainur F. Nasretdinov |
| collection | DOAJ |
| description | Knowledge of the molecular characteristics of the progression of non-small cell lung tumors currently provides the patient with the best treatment options. One of the most well-known and studied genetic abnormalities is a mutation in the EGFR gene, which makes the tumor sensitive to therapy with tyrosine kinase inhibitors. In the conditions of the existence of several therapeutic options at once, it is required to know not only the results of clinical trials, but also the fundamental features of the mechanisms of action of a particular drug. The article contains a literature review, presenting the features of the functioning of EGFR (epidermal growth factor receptor), the mechanisms of action of EGFR inhibitors of different generations (erlotinib, gefitinib, afatinib, osimertinib), generalization and analysis of the main differences between them. |
| first_indexed | 2024-04-11T15:04:28Z |
| format | Article |
| id | doaj.art-ebd429d188994256bcbd1e16341b2425 |
| institution | Directory Open Access Journal |
| issn | 1815-1434 1815-1442 |
| language | Russian |
| last_indexed | 2024-04-11T15:04:28Z |
| publishDate | 2022-11-01 |
| publisher | IP Habib O.N. |
| record_format | Article |
| series | Современная онкология |
| spelling | doaj.art-ebd429d188994256bcbd1e16341b24252022-12-22T04:16:51ZrusIP Habib O.N.Современная онкология1815-14341815-14422022-11-0124334034410.26442/18151434.2022.3.20181379429The mechanism of action of different generations of EGFR-inhibitors in malignant lung tumors. Literature review and data synthesisAinur F. Nasretdinov0https://orcid.org/0000-0001-8340-7962Konstantin V. Menshikov1https://orcid.org/0000-0003-3734-2779Alexander V. Sultanbaev2https://orcid.org/0000-0003-0996-5995Shamil I. Musin3https://orcid.org/0000-0003-1185-977XNadezda I. Sultanbaeva4https://orcid.org/0000-0001-5926-0446Irina A. Men'shikova5https://orcid.org/0000-0002-8665-8895Republican Clinical Oncological DispensaryRepublican Clinical Oncological DispensaryRepublican Clinical Oncological DispensaryRepublican Clinical Oncological DispensaryRepublican Clinical Oncological DispensaryBashkir State Medical UniversityKnowledge of the molecular characteristics of the progression of non-small cell lung tumors currently provides the patient with the best treatment options. One of the most well-known and studied genetic abnormalities is a mutation in the EGFR gene, which makes the tumor sensitive to therapy with tyrosine kinase inhibitors. In the conditions of the existence of several therapeutic options at once, it is required to know not only the results of clinical trials, but also the fundamental features of the mechanisms of action of a particular drug. The article contains a literature review, presenting the features of the functioning of EGFR (epidermal growth factor receptor), the mechanisms of action of EGFR inhibitors of different generations (erlotinib, gefitinib, afatinib, osimertinib), generalization and analysis of the main differences between them.https://modernonco.orscience.ru/1815-1434/article/viewFile/105003/pdflung cancertyrosine kinase inhibitorsegfrerlotinibgefitinibafatinibosimertinib |
| spellingShingle | Ainur F. Nasretdinov Konstantin V. Menshikov Alexander V. Sultanbaev Shamil I. Musin Nadezda I. Sultanbaeva Irina A. Men'shikova The mechanism of action of different generations of EGFR-inhibitors in malignant lung tumors. Literature review and data synthesis Современная онкология lung cancer tyrosine kinase inhibitors egfr erlotinib gefitinib afatinib osimertinib |
| title | The mechanism of action of different generations of EGFR-inhibitors in malignant lung tumors. Literature review and data synthesis |
| title_full | The mechanism of action of different generations of EGFR-inhibitors in malignant lung tumors. Literature review and data synthesis |
| title_fullStr | The mechanism of action of different generations of EGFR-inhibitors in malignant lung tumors. Literature review and data synthesis |
| title_full_unstemmed | The mechanism of action of different generations of EGFR-inhibitors in malignant lung tumors. Literature review and data synthesis |
| title_short | The mechanism of action of different generations of EGFR-inhibitors in malignant lung tumors. Literature review and data synthesis |
| title_sort | mechanism of action of different generations of egfr inhibitors in malignant lung tumors literature review and data synthesis |
| topic | lung cancer tyrosine kinase inhibitors egfr erlotinib gefitinib afatinib osimertinib |
| url | https://modernonco.orscience.ru/1815-1434/article/viewFile/105003/pdf |
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