Decreased cognition is associated with altered cardiovascular autonomic functions and decreased baroreflex sensitivity in women with premenstrual syndrome
Premenstrual syndrome (PMS) is a clinical entity of concern in women of reproductive age group with its onset during the late luteal phase of the menstrual cycle that typically resolves within a few days after the onset of menstruation. Female reproductive hormones stimulate the gene promotor region...
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| Format: | Article |
| Language: | English |
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Ion Motofei, Carol Davila University
2022-04-01
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| Series: | Journal of Mind and Medical Sciences |
| Subjects: | |
| Online Access: | https://scholar.valpo.edu/cgi/viewcontent.cgi?article=1325&context=jmms |
| _version_ | 1811332481727594496 |
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| author | Jothi Marie Feula Dhanalakshmi Yerrabelli Gopal Krushna Pal Soundirarajan Subhashri |
| author_facet | Jothi Marie Feula Dhanalakshmi Yerrabelli Gopal Krushna Pal Soundirarajan Subhashri |
| author_sort | Jothi Marie Feula |
| collection | DOAJ |
| description | Premenstrual syndrome (PMS) is a clinical entity of concern in women of reproductive age group with its onset during the late luteal phase of the menstrual cycle that typically resolves within a few days after the onset of menstruation. Female reproductive hormones stimulate the gene promotor region of Gonadal steroids, which are modulators of the hypothalamic-pituitary axis, in association with the autonomic nervous system (ANS), form the stress system, which regulates the homeostatic mechanisms of the body. Disruption of this mechanism can lead to sympathovagal imbalance and cognitive deficits. Objectives: This study was aimed to compare the autonomic functions and cognition between PMS and control group. Methodology: This cross-sectional study was conducted as a pilot study with 20 subjects in each group. Autonomic function test and P300 were recorded. Study participants were also asked to answer Montreal cognitive assessment (MOCA) questionnaire. Results: On comparison of the test results between the two groups, individuals in PMS group were found to have increased sympathetic activity and reduced cognition when compared to the no PMS (control) group. Conclusion: The findings from this study proves a detrimental effect of gonadal steroids on autonomic nervous system and cognition. |
| first_indexed | 2024-04-13T16:36:42Z |
| format | Article |
| id | doaj.art-ebd613cd77084dcc81adb9f36acc5a90 |
| institution | Directory Open Access Journal |
| issn | 2392-7674 |
| language | English |
| last_indexed | 2024-04-13T16:36:42Z |
| publishDate | 2022-04-01 |
| publisher | Ion Motofei, Carol Davila University |
| record_format | Article |
| series | Journal of Mind and Medical Sciences |
| spelling | doaj.art-ebd613cd77084dcc81adb9f36acc5a902022-12-22T02:39:24ZengIon Motofei, Carol Davila UniversityJournal of Mind and Medical Sciences2392-76742022-04-019118118610.22543/7674.91.P181186Decreased cognition is associated with altered cardiovascular autonomic functions and decreased baroreflex sensitivity in women with premenstrual syndromeJothi Marie Feula0Dhanalakshmi Yerrabelli1Gopal Krushna Pal2Soundirarajan Subhashri3ASSISTANT PROFESSOR, DEPARTMENT OF PHYSIOLOGY, AARUPADAI VEEDU MEDICAL COLLEGE & HOSPITAL, VINAYAKA MISSIONS RESEARCH FOUNDATION – DEEMED TO BE UNIVERSITY, PUDUCHERRYADDITIONAL PROFESSOR, DEPARTMENT OF PHYSIOLOGY, JIPMER, PUDUCHERRYSENIOR PROFESSOR, DEPARTMENT OF PHYSIOLOGY, JIPMER, PUDUCHERRYASSISTANT PROFESSOR, DEPARTMENT OF PHYSIOLOGY, SRI VENKATESHWARA MEDICAL COLLEGE HOSPITAL AND RESEARCH INSTITUTE, PUDUCHERRYPremenstrual syndrome (PMS) is a clinical entity of concern in women of reproductive age group with its onset during the late luteal phase of the menstrual cycle that typically resolves within a few days after the onset of menstruation. Female reproductive hormones stimulate the gene promotor region of Gonadal steroids, which are modulators of the hypothalamic-pituitary axis, in association with the autonomic nervous system (ANS), form the stress system, which regulates the homeostatic mechanisms of the body. Disruption of this mechanism can lead to sympathovagal imbalance and cognitive deficits. Objectives: This study was aimed to compare the autonomic functions and cognition between PMS and control group. Methodology: This cross-sectional study was conducted as a pilot study with 20 subjects in each group. Autonomic function test and P300 were recorded. Study participants were also asked to answer Montreal cognitive assessment (MOCA) questionnaire. Results: On comparison of the test results between the two groups, individuals in PMS group were found to have increased sympathetic activity and reduced cognition when compared to the no PMS (control) group. Conclusion: The findings from this study proves a detrimental effect of gonadal steroids on autonomic nervous system and cognition.https://scholar.valpo.edu/cgi/viewcontent.cgi?article=1325&context=jmmscognitioncardiovascularautonomic functionsbaroreflex sensitivitysympathovagal imbalancewomenpremenstrual syndrome |
| spellingShingle | Jothi Marie Feula Dhanalakshmi Yerrabelli Gopal Krushna Pal Soundirarajan Subhashri Decreased cognition is associated with altered cardiovascular autonomic functions and decreased baroreflex sensitivity in women with premenstrual syndrome Journal of Mind and Medical Sciences cognition cardiovascular autonomic functions baroreflex sensitivity sympathovagal imbalance women premenstrual syndrome |
| title | Decreased cognition is associated with altered cardiovascular autonomic functions and decreased baroreflex sensitivity in women with premenstrual syndrome |
| title_full | Decreased cognition is associated with altered cardiovascular autonomic functions and decreased baroreflex sensitivity in women with premenstrual syndrome |
| title_fullStr | Decreased cognition is associated with altered cardiovascular autonomic functions and decreased baroreflex sensitivity in women with premenstrual syndrome |
| title_full_unstemmed | Decreased cognition is associated with altered cardiovascular autonomic functions and decreased baroreflex sensitivity in women with premenstrual syndrome |
| title_short | Decreased cognition is associated with altered cardiovascular autonomic functions and decreased baroreflex sensitivity in women with premenstrual syndrome |
| title_sort | decreased cognition is associated with altered cardiovascular autonomic functions and decreased baroreflex sensitivity in women with premenstrual syndrome |
| topic | cognition cardiovascular autonomic functions baroreflex sensitivity sympathovagal imbalance women premenstrual syndrome |
| url | https://scholar.valpo.edu/cgi/viewcontent.cgi?article=1325&context=jmms |
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