Clinical significance of epidermal growth factor receptor mutations in resected stage IA non-small cell lung cancer
Background: Epidermal growth factor receptor (EGFR) gene mutation is a known predictor of the response to EGFR tyrosine kinase inhibitors. However, detecting EGFR mutations is a potential challenge because of the ground-glass opacity component, and its prognostic value for stage IA lung adenocarcino...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Health/LWW
2022-01-01
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| Series: | Formosan Journal of Surgery |
| Subjects: | |
| Online Access: | http://www.e-fjs.org/article.asp?issn=1682-606X;year=2022;volume=55;issue=3;spage=109;epage=115;aulast=Tsai |
| _version_ | 1797761275190575104 |
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| author | Yuan-Ming Tsai Kuan-Hsun Lin Yen-Shou Kuo Yu-Chieh Lin Yu-Hsin Chien Hsiu-Ping Chou Ying-Yi Chen Hsu-Kai Huang Ti-Hui Wu Hung Chang Shih-Chun Lee Tsai-Wang Huang |
| author_facet | Yuan-Ming Tsai Kuan-Hsun Lin Yen-Shou Kuo Yu-Chieh Lin Yu-Hsin Chien Hsiu-Ping Chou Ying-Yi Chen Hsu-Kai Huang Ti-Hui Wu Hung Chang Shih-Chun Lee Tsai-Wang Huang |
| author_sort | Yuan-Ming Tsai |
| collection | DOAJ |
| description | Background: Epidermal growth factor receptor (EGFR) gene mutation is a known predictor of the response to EGFR tyrosine kinase inhibitors. However, detecting EGFR mutations is a potential challenge because of the ground-glass opacity component, and its prognostic value for stage IA lung adenocarcinoma remains controversial. This study aimed to investigate the associations between EGFR mutation status, clinicopathological characteristics, and prognosis in surgically resected stage IA non-small cell lung cancer (NSCLC).
Materials and Methods: We retrospectively examined the data of patients who underwent surgical resection for lung cancer between 2004 and 2014. The clinical data, imaging characteristics of nodules, surgical approaches, and outcomes were analyzed.
Results: A total of 429 patients (female, n = 303; male, n = 126) with surgically resected stage IA NSCLC were analyzed and 343 were nonsmokers. The EGFR mutation rate was 48.3% (n = 207). Of the patients, 192 (44.8%) had stage IA1, 165 (38.5%) had stage IA2, and 72 (16.8%) had stage IA3 NSCLC. In the analysis of the correlations between clinicopathological features and EGFR status, older age (P = 0.032), nonsmoking history (P = 0.039), and pathological stage (P < 0.05) were related to EGFR mutation. Patients with stage IA2 NSCLC had a higher positive expression of EGFR than patients with stages IA1 and IA3. The 5-year overall survival rates and disease-free survival rates were better in the EGFR mutation group; however, the difference was not statistically significant.
Conclusion: EGFR mutations are common in older and nonsmoking patients with stage IA NSCLC. Further separate analyses of EGFR gene mutations and pathological stage could improve the diagnostic performance and predict patients with unavailable EGFR gene testing who may benefit from targeted drug treatment. |
| first_indexed | 2024-03-12T19:10:37Z |
| format | Article |
| id | doaj.art-ebda58ce284d402ea96132a4f6704dd1 |
| institution | Directory Open Access Journal |
| issn | 1682-606X |
| language | English |
| last_indexed | 2024-03-12T19:10:37Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Health/LWW |
| record_format | Article |
| series | Formosan Journal of Surgery |
| spelling | doaj.art-ebda58ce284d402ea96132a4f6704dd12023-08-02T05:56:49ZengWolters Kluwer Health/LWWFormosan Journal of Surgery1682-606X2022-01-0155310911510.4103/fjs.fjs_104_22Clinical significance of epidermal growth factor receptor mutations in resected stage IA non-small cell lung cancerYuan-Ming TsaiKuan-Hsun LinYen-Shou KuoYu-Chieh LinYu-Hsin ChienHsiu-Ping ChouYing-Yi ChenHsu-Kai HuangTi-Hui WuHung ChangShih-Chun LeeTsai-Wang HuangBackground: Epidermal growth factor receptor (EGFR) gene mutation is a known predictor of the response to EGFR tyrosine kinase inhibitors. However, detecting EGFR mutations is a potential challenge because of the ground-glass opacity component, and its prognostic value for stage IA lung adenocarcinoma remains controversial. This study aimed to investigate the associations between EGFR mutation status, clinicopathological characteristics, and prognosis in surgically resected stage IA non-small cell lung cancer (NSCLC). Materials and Methods: We retrospectively examined the data of patients who underwent surgical resection for lung cancer between 2004 and 2014. The clinical data, imaging characteristics of nodules, surgical approaches, and outcomes were analyzed. Results: A total of 429 patients (female, n = 303; male, n = 126) with surgically resected stage IA NSCLC were analyzed and 343 were nonsmokers. The EGFR mutation rate was 48.3% (n = 207). Of the patients, 192 (44.8%) had stage IA1, 165 (38.5%) had stage IA2, and 72 (16.8%) had stage IA3 NSCLC. In the analysis of the correlations between clinicopathological features and EGFR status, older age (P = 0.032), nonsmoking history (P = 0.039), and pathological stage (P < 0.05) were related to EGFR mutation. Patients with stage IA2 NSCLC had a higher positive expression of EGFR than patients with stages IA1 and IA3. The 5-year overall survival rates and disease-free survival rates were better in the EGFR mutation group; however, the difference was not statistically significant. Conclusion: EGFR mutations are common in older and nonsmoking patients with stage IA NSCLC. Further separate analyses of EGFR gene mutations and pathological stage could improve the diagnostic performance and predict patients with unavailable EGFR gene testing who may benefit from targeted drug treatment.http://www.e-fjs.org/article.asp?issn=1682-606X;year=2022;volume=55;issue=3;spage=109;epage=115;aulast=Tsaiageepidermal growth factor receptorlung adenocarcinomaoverall survivalprognosisstage ia |
| spellingShingle | Yuan-Ming Tsai Kuan-Hsun Lin Yen-Shou Kuo Yu-Chieh Lin Yu-Hsin Chien Hsiu-Ping Chou Ying-Yi Chen Hsu-Kai Huang Ti-Hui Wu Hung Chang Shih-Chun Lee Tsai-Wang Huang Clinical significance of epidermal growth factor receptor mutations in resected stage IA non-small cell lung cancer Formosan Journal of Surgery age epidermal growth factor receptor lung adenocarcinoma overall survival prognosis stage ia |
| title | Clinical significance of epidermal growth factor receptor mutations in resected stage IA non-small cell lung cancer |
| title_full | Clinical significance of epidermal growth factor receptor mutations in resected stage IA non-small cell lung cancer |
| title_fullStr | Clinical significance of epidermal growth factor receptor mutations in resected stage IA non-small cell lung cancer |
| title_full_unstemmed | Clinical significance of epidermal growth factor receptor mutations in resected stage IA non-small cell lung cancer |
| title_short | Clinical significance of epidermal growth factor receptor mutations in resected stage IA non-small cell lung cancer |
| title_sort | clinical significance of epidermal growth factor receptor mutations in resected stage ia non small cell lung cancer |
| topic | age epidermal growth factor receptor lung adenocarcinoma overall survival prognosis stage ia |
| url | http://www.e-fjs.org/article.asp?issn=1682-606X;year=2022;volume=55;issue=3;spage=109;epage=115;aulast=Tsai |
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