Advances in peptide-based drug delivery systems
Drug delivery systems (DDSs) are designed to deliver drugs to their specific targets to minimize their toxic effects and improve their susceptibility to clearance during targeted transport. Peptides have high affinity, low immunogenicity, simple amino acid composition, and adjustable molecular size;...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-02-01
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| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024020401 |
| _version_ | 1797267773825482752 |
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| author | Sijie Guo Jing Wang Qi Wang Jinxin Wang Song Qin Wenjun Li |
| author_facet | Sijie Guo Jing Wang Qi Wang Jinxin Wang Song Qin Wenjun Li |
| author_sort | Sijie Guo |
| collection | DOAJ |
| description | Drug delivery systems (DDSs) are designed to deliver drugs to their specific targets to minimize their toxic effects and improve their susceptibility to clearance during targeted transport. Peptides have high affinity, low immunogenicity, simple amino acid composition, and adjustable molecular size; therefore, most peptides can be coupled to drugs via linkers to form peptide-drug conjugates (PDCs) and act as active pro-drugs. PDCs are widely thought to be promising DDSs, given their ability to improve drug bio-compatibility and physiological stability. Peptide-based DDSs are often used to deliver therapeutic substances such as anti-cancer drugs and nucleic acid-based drugs, which not only slow the degradation rate of drugs in vivo but also ensure the drug concentration at the targeted site and prolong the half-life of drugs in vivo. This article provides an profile of the advancements and future development in functional peptide-based DDSs both domestically and internationally in recent years, in the expectation of achieving targeted drug delivery incorporating functional peptides and taking full advantage of synergistic effects. |
| first_indexed | 2024-04-25T01:21:55Z |
| format | Article |
| id | doaj.art-ebdc36a3bfac47bc9e3c51b52150a378 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-25T01:21:55Z |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-ebdc36a3bfac47bc9e3c51b52150a3782024-03-09T09:26:51ZengElsevierHeliyon2405-84402024-02-01104e26009Advances in peptide-based drug delivery systemsSijie Guo0Jing Wang1Qi Wang2Jinxin Wang3Song Qin4Wenjun Li5Qingdao Academy of Chinese Medical Sciences, Shandong University of Traditional Chinese Medicine, Qingdao, Shandong, 266112, China; Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai, Shandong, 264003, ChinaYantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai, Shandong, 264003, ChinaQingdao Academy of Chinese Medical Sciences, Shandong University of Traditional Chinese Medicine, Qingdao, Shandong, 266112, China; Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai, Shandong, 264003, ChinaCollege of Life Sciences, Yantai University, Yantai, 264005, ChinaYantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai, Shandong, 264003, ChinaQingdao Academy of Chinese Medical Sciences, Shandong University of Traditional Chinese Medicine, Qingdao, Shandong, 266112, China; Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai, Shandong, 264003, China; Corresponding author. Qingdao Academy of Chinese Medical Sciences, Shandong University of Traditional Chinese Medicine, Qingdao, Shandong, 266112, China.Drug delivery systems (DDSs) are designed to deliver drugs to their specific targets to minimize their toxic effects and improve their susceptibility to clearance during targeted transport. Peptides have high affinity, low immunogenicity, simple amino acid composition, and adjustable molecular size; therefore, most peptides can be coupled to drugs via linkers to form peptide-drug conjugates (PDCs) and act as active pro-drugs. PDCs are widely thought to be promising DDSs, given their ability to improve drug bio-compatibility and physiological stability. Peptide-based DDSs are often used to deliver therapeutic substances such as anti-cancer drugs and nucleic acid-based drugs, which not only slow the degradation rate of drugs in vivo but also ensure the drug concentration at the targeted site and prolong the half-life of drugs in vivo. This article provides an profile of the advancements and future development in functional peptide-based DDSs both domestically and internationally in recent years, in the expectation of achieving targeted drug delivery incorporating functional peptides and taking full advantage of synergistic effects.http://www.sciencedirect.com/science/article/pii/S2405844024020401Functional peptideDrug delivery systemPeptide-drug couplingApplication prospects |
| spellingShingle | Sijie Guo Jing Wang Qi Wang Jinxin Wang Song Qin Wenjun Li Advances in peptide-based drug delivery systems Heliyon Functional peptide Drug delivery system Peptide-drug coupling Application prospects |
| title | Advances in peptide-based drug delivery systems |
| title_full | Advances in peptide-based drug delivery systems |
| title_fullStr | Advances in peptide-based drug delivery systems |
| title_full_unstemmed | Advances in peptide-based drug delivery systems |
| title_short | Advances in peptide-based drug delivery systems |
| title_sort | advances in peptide based drug delivery systems |
| topic | Functional peptide Drug delivery system Peptide-drug coupling Application prospects |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024020401 |
| work_keys_str_mv | AT sijieguo advancesinpeptidebaseddrugdeliverysystems AT jingwang advancesinpeptidebaseddrugdeliverysystems AT qiwang advancesinpeptidebaseddrugdeliverysystems AT jinxinwang advancesinpeptidebaseddrugdeliverysystems AT songqin advancesinpeptidebaseddrugdeliverysystems AT wenjunli advancesinpeptidebaseddrugdeliverysystems |