Simple model systems reveal conserved mechanisms of Alzheimer’s disease and related tauopathies
Abstract The lack of effective therapies that slow the progression of Alzheimer’s disease (AD) and related tauopathies highlights the need for a more comprehensive understanding of the fundamental cellular mechanisms underlying these diseases. Model organisms, including yeast, worms, and flies, prov...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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BMC
2023-11-01
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| Series: | Molecular Neurodegeneration |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13024-023-00664-x |
| _version_ | 1797629991519780864 |
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| author | Yuwei Jiang Lesley T. MacNeil |
| author_facet | Yuwei Jiang Lesley T. MacNeil |
| author_sort | Yuwei Jiang |
| collection | DOAJ |
| description | Abstract The lack of effective therapies that slow the progression of Alzheimer’s disease (AD) and related tauopathies highlights the need for a more comprehensive understanding of the fundamental cellular mechanisms underlying these diseases. Model organisms, including yeast, worms, and flies, provide simple systems with which to investigate the mechanisms of disease. The evolutionary conservation of cellular pathways regulating proteostasis and stress response in these organisms facilitates the study of genetic factors that contribute to, or protect against, neurodegeneration. Here, we review genetic modifiers of neurodegeneration and related cellular pathways identified in the budding yeast Saccharomyces cerevisiae, the nematode Caenorhabditis elegans, and the fruit fly Drosophila melanogaster, focusing on models of AD and related tauopathies. We further address the potential of simple model systems to better understand the fundamental mechanisms that lead to AD and other neurodegenerative disorders. |
| first_indexed | 2024-03-11T11:01:42Z |
| format | Article |
| id | doaj.art-ebdd763474174779bd069e51e9f31256 |
| institution | Directory Open Access Journal |
| issn | 1750-1326 |
| language | English |
| last_indexed | 2024-03-11T11:01:42Z |
| publishDate | 2023-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Neurodegeneration |
| spelling | doaj.art-ebdd763474174779bd069e51e9f312562023-11-12T12:30:04ZengBMCMolecular Neurodegeneration1750-13262023-11-0118112310.1186/s13024-023-00664-xSimple model systems reveal conserved mechanisms of Alzheimer’s disease and related tauopathiesYuwei Jiang0Lesley T. MacNeil1Department of Biochemistry and Biomedical Sciences, McMaster UniversityDepartment of Biochemistry and Biomedical Sciences, McMaster UniversityAbstract The lack of effective therapies that slow the progression of Alzheimer’s disease (AD) and related tauopathies highlights the need for a more comprehensive understanding of the fundamental cellular mechanisms underlying these diseases. Model organisms, including yeast, worms, and flies, provide simple systems with which to investigate the mechanisms of disease. The evolutionary conservation of cellular pathways regulating proteostasis and stress response in these organisms facilitates the study of genetic factors that contribute to, or protect against, neurodegeneration. Here, we review genetic modifiers of neurodegeneration and related cellular pathways identified in the budding yeast Saccharomyces cerevisiae, the nematode Caenorhabditis elegans, and the fruit fly Drosophila melanogaster, focusing on models of AD and related tauopathies. We further address the potential of simple model systems to better understand the fundamental mechanisms that lead to AD and other neurodegenerative disorders.https://doi.org/10.1186/s13024-023-00664-xNeurodegenerationAggregationAlzheimer’s diseaseTauopathyAmyloid-βGenetic modifiers |
| spellingShingle | Yuwei Jiang Lesley T. MacNeil Simple model systems reveal conserved mechanisms of Alzheimer’s disease and related tauopathies Molecular Neurodegeneration Neurodegeneration Aggregation Alzheimer’s disease Tauopathy Amyloid-β Genetic modifiers |
| title | Simple model systems reveal conserved mechanisms of Alzheimer’s disease and related tauopathies |
| title_full | Simple model systems reveal conserved mechanisms of Alzheimer’s disease and related tauopathies |
| title_fullStr | Simple model systems reveal conserved mechanisms of Alzheimer’s disease and related tauopathies |
| title_full_unstemmed | Simple model systems reveal conserved mechanisms of Alzheimer’s disease and related tauopathies |
| title_short | Simple model systems reveal conserved mechanisms of Alzheimer’s disease and related tauopathies |
| title_sort | simple model systems reveal conserved mechanisms of alzheimer s disease and related tauopathies |
| topic | Neurodegeneration Aggregation Alzheimer’s disease Tauopathy Amyloid-β Genetic modifiers |
| url | https://doi.org/10.1186/s13024-023-00664-x |
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