The Curcumin Analogue 1,5-Bis(2-hydroxyphenyl)-1,4-pentadiene-3-one Induces Apoptosis and Downregulates E6 and E7 Oncogene Expression in HPV16 and HPV18-Infected Cervical Cancer Cells

The Curcumin Analogue 1,5-Bis(2-hydroxyphenyl)-1,4-pentadiene-3-one Induces Apoptosis and Downregulates E6 and E7 Oncogene Expression in HPV16 and HPV18-Infected Cervical Cancer Cells

In an effort to study curcumin analogues as an alternative to improve the therapeutic efficacy of curcumin, we screened the cytotoxic potential of four diarylpentanoids using the HeLa and CaSki cervical cancer cell lines. Determination of their EC50 values indicated relatively higher potency of 1,5-...

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Bibliographic Details
Main Authors: Felicia Paulraj, Faridah Abas, Nordin H. Lajis, Iekhsan Othman, Sharifah Syed Hassan, Rakesh Naidu
Format: Article
Language:English
Published: MDPI AG 2015-06-01
Series:Molecules
Subjects:
curcumin analogue
diarylpentanoid
cervical cancer
cytotoxicity
apoptosis
oncogene
E6
E7
HeLa cells
CaSki cells
Online Access:http://www.mdpi.com/1420-3049/20/7/11830

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