Abnormal functional connectivity of the striatum in first‐episode drug‐naive early‐onset Schizophrenia
Abstract Abnormal brain network connectivity is strongly implicated in the pathogenesis of schizophrenia. The striatum, consisting of the caudate and putamen, is the major treatment target for antipsychotics, the primary treatments for schizophrenia; however, there are few studies on the functional...
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| Format: | Article |
| Language: | English |
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Wiley
2022-05-01
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| Series: | Brain and Behavior |
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| Online Access: | https://doi.org/10.1002/brb3.2535 |
| _version_ | 1827860643822174208 |
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| author | Yan Zhang Yue Peng Yichen Song Youqi Zhou Sen Zhang Ge Yang Yongfeng Yang Wenqiang Li Weihua Yue Luxian Lv Dai Zhang |
| author_facet | Yan Zhang Yue Peng Yichen Song Youqi Zhou Sen Zhang Ge Yang Yongfeng Yang Wenqiang Li Weihua Yue Luxian Lv Dai Zhang |
| author_sort | Yan Zhang |
| collection | DOAJ |
| description | Abstract Abnormal brain network connectivity is strongly implicated in the pathogenesis of schizophrenia. The striatum, consisting of the caudate and putamen, is the major treatment target for antipsychotics, the primary treatments for schizophrenia; however, there are few studies on the functional connectivity (FC) of striatum in drug‐naive early‐onset schizophrenia (EOS) patients. We examined the FC values of the caudate nucleus and putamen with whole brain by resting‐state functional magnetic resonance imaging (RS‐fMRI) and the associations with indices of clinical severity. Patients demonstrated abnormal FC between subregions of the putamen and both the visual network (left middle occipital gyrus) and default mode network (bilateral anterior cingulate, left superior frontal, and right middle frontal gyri). Furthermore, FC between dorsorostral putamen and left superior frontal gyrus correlated with both positive symptom subscore and total score on the Positive and Negative Syndrome Scale (PANSS). These findings demonstrate abnormal FC between the striatum and other brain areas even in the early stages of schizophrenia, supporting neurodevelopmental disruption in disease etiology and expression. |
| first_indexed | 2024-03-12T13:26:58Z |
| format | Article |
| id | doaj.art-ebdf183f929840deb5bdb6207deb9450 |
| institution | Directory Open Access Journal |
| issn | 2162-3279 |
| language | English |
| last_indexed | 2024-03-12T13:26:58Z |
| publishDate | 2022-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain and Behavior |
| spelling | doaj.art-ebdf183f929840deb5bdb6207deb94502023-08-25T04:42:55ZengWileyBrain and Behavior2162-32792022-05-01125n/an/a10.1002/brb3.2535Abnormal functional connectivity of the striatum in first‐episode drug‐naive early‐onset SchizophreniaYan Zhang0Yue Peng1Yichen Song2Youqi Zhou3Sen Zhang4Ge Yang5Yongfeng Yang6Wenqiang Li7Weihua Yue8Luxian Lv9Dai Zhang10Psychiatry Institute of Mental Health/Peking University Sixth Hospital Peking University Beijing ChinaDepartment of Pediatric Rehabilitation Medicine The Fifth Affiliated Hospital of Zhengzhou University Zhengzhou Henan ChinaHenan Mental Hospital The Second Affiliated Hospital of Xinxiang Medical University Xinxiang ChinaHenan Mental Hospital The Second Affiliated Hospital of Xinxiang Medical University Xinxiang ChinaChild and Adolescent Psychiatry Department Mental Health Center of Shantou University Shantou Guangdong ChinaHenan Mental Hospital The Second Affiliated Hospital of Xinxiang Medical University Xinxiang ChinaHenan Mental Hospital The Second Affiliated Hospital of Xinxiang Medical University Xinxiang ChinaHenan Mental Hospital The Second Affiliated Hospital of Xinxiang Medical University Xinxiang ChinaPsychiatry Institute of Mental Health/Peking University Sixth Hospital Peking University Beijing ChinaHenan Mental Hospital The Second Affiliated Hospital of Xinxiang Medical University Xinxiang ChinaPsychiatry Institute of Mental Health/Peking University Sixth Hospital Peking University Beijing ChinaAbstract Abnormal brain network connectivity is strongly implicated in the pathogenesis of schizophrenia. The striatum, consisting of the caudate and putamen, is the major treatment target for antipsychotics, the primary treatments for schizophrenia; however, there are few studies on the functional connectivity (FC) of striatum in drug‐naive early‐onset schizophrenia (EOS) patients. We examined the FC values of the caudate nucleus and putamen with whole brain by resting‐state functional magnetic resonance imaging (RS‐fMRI) and the associations with indices of clinical severity. Patients demonstrated abnormal FC between subregions of the putamen and both the visual network (left middle occipital gyrus) and default mode network (bilateral anterior cingulate, left superior frontal, and right middle frontal gyri). Furthermore, FC between dorsorostral putamen and left superior frontal gyrus correlated with both positive symptom subscore and total score on the Positive and Negative Syndrome Scale (PANSS). These findings demonstrate abnormal FC between the striatum and other brain areas even in the early stages of schizophrenia, supporting neurodevelopmental disruption in disease etiology and expression.https://doi.org/10.1002/brb3.2535early‐onset schizophreniafunctional connectivityregion of interestresting statestriatum |
| spellingShingle | Yan Zhang Yue Peng Yichen Song Youqi Zhou Sen Zhang Ge Yang Yongfeng Yang Wenqiang Li Weihua Yue Luxian Lv Dai Zhang Abnormal functional connectivity of the striatum in first‐episode drug‐naive early‐onset Schizophrenia Brain and Behavior early‐onset schizophrenia functional connectivity region of interest resting state striatum |
| title | Abnormal functional connectivity of the striatum in first‐episode drug‐naive early‐onset Schizophrenia |
| title_full | Abnormal functional connectivity of the striatum in first‐episode drug‐naive early‐onset Schizophrenia |
| title_fullStr | Abnormal functional connectivity of the striatum in first‐episode drug‐naive early‐onset Schizophrenia |
| title_full_unstemmed | Abnormal functional connectivity of the striatum in first‐episode drug‐naive early‐onset Schizophrenia |
| title_short | Abnormal functional connectivity of the striatum in first‐episode drug‐naive early‐onset Schizophrenia |
| title_sort | abnormal functional connectivity of the striatum in first episode drug naive early onset schizophrenia |
| topic | early‐onset schizophrenia functional connectivity region of interest resting state striatum |
| url | https://doi.org/10.1002/brb3.2535 |
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