The relationship between serotonine, histamine and the brain`s electrical activity in patients with depression and endocrine disorders
Introduction. Depression is a persistent mental state of sadness that can affect an individual`s thoughts, behavior, emotion and well-being. The electroencephalogram (EEG) is of great importance both for experimental neurophysiology and for clinical diagnosis. The purpose of our study was to establi...
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| Format: | Article |
| Language: | English |
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Amaltea Medical Publishing House
2021-06-01
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| Series: | Romanian Medical Journal |
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| Online Access: | https://rmj.com.ro/articles/2021.2/RMJ_2021_2_Art-22.pdf |
| _version_ | 1797333713942478848 |
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| author | Oana-Maria Nicola (Marioara) Alice Elena Ghenea Cristina-Nicoleta Vlădoianu Mara Carsote Mihaela Popescu |
| author_facet | Oana-Maria Nicola (Marioara) Alice Elena Ghenea Cristina-Nicoleta Vlădoianu Mara Carsote Mihaela Popescu |
| author_sort | Oana-Maria Nicola (Marioara) |
| collection | DOAJ |
| description | Introduction. Depression is a persistent mental state of sadness that can affect an individual`s thoughts, behavior, emotion and well-being. The electroencephalogram (EEG) is of great importance both for experimental neurophysiology and for clinical diagnosis. The purpose of our study was to establish if there is a connection between the values of serotonine, histamine and EEG in patients with depression and endocrine pathology based on the collected data.
Materials and methods. We included 50 individuals diagnosed with depression from Endocrinology Clinic of Craiova, over a period of 2 years (2018-2020). Serotonine and histamine were measured in blood and urine/24 hours in all the sample. Electroencephalography was performed to this patients.
Outcomes. In our study, 27 patients had mild depression, 17 had moderate depression and 6 had a severe disorder. Also, the serotonine values were low (normal value 80-400 μg/L) in patients with depression and endocrine pathology.
Conclusion. In patients with EEG abnormalities occure significant changes in the values of serotonine and histamine (increased urinary histamine and decreased serotonine levels). |
| first_indexed | 2024-03-08T08:08:58Z |
| format | Article |
| id | doaj.art-ebe07ee27ba94dc78c4486bdf0461d1d |
| institution | Directory Open Access Journal |
| issn | 1220-5478 2069-606X |
| language | English |
| last_indexed | 2024-03-08T08:08:58Z |
| publishDate | 2021-06-01 |
| publisher | Amaltea Medical Publishing House |
| record_format | Article |
| series | Romanian Medical Journal |
| spelling | doaj.art-ebe07ee27ba94dc78c4486bdf0461d1d2024-02-02T09:43:22ZengAmaltea Medical Publishing HouseRomanian Medical Journal1220-54782069-606X2021-06-0168227327710.37897/RMJ.2021.2.22The relationship between serotonine, histamine and the brain`s electrical activity in patients with depression and endocrine disordersOana-Maria Nicola (Marioara)0Alice Elena Ghenea1Cristina-Nicoleta Vlădoianu2Mara Carsote3Mihaela Popescu4Neurology, Municipal Hospital, Caracal, RomaniaDepartament of Bacteriology-Virology-Parasitology, University of Medicine and Pharmacy, Craiova, Romania; Clinical Emergency County Hospital, Craiova, RomaniaEndocrinology, Filantropia Clinical Hospital, Craiova, Romania“Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania; “C.I.Parhon” National Institute of Endocrinology, Bucharest, RomaniaDepartment of Endocrinology, University of Medicine and Pharmacy, Craiova, RomaniaIntroduction. Depression is a persistent mental state of sadness that can affect an individual`s thoughts, behavior, emotion and well-being. The electroencephalogram (EEG) is of great importance both for experimental neurophysiology and for clinical diagnosis. The purpose of our study was to establish if there is a connection between the values of serotonine, histamine and EEG in patients with depression and endocrine pathology based on the collected data. Materials and methods. We included 50 individuals diagnosed with depression from Endocrinology Clinic of Craiova, over a period of 2 years (2018-2020). Serotonine and histamine were measured in blood and urine/24 hours in all the sample. Electroencephalography was performed to this patients. Outcomes. In our study, 27 patients had mild depression, 17 had moderate depression and 6 had a severe disorder. Also, the serotonine values were low (normal value 80-400 μg/L) in patients with depression and endocrine pathology. Conclusion. In patients with EEG abnormalities occure significant changes in the values of serotonine and histamine (increased urinary histamine and decreased serotonine levels).https://rmj.com.ro/articles/2021.2/RMJ_2021_2_Art-22.pdfserotoninehistamineeegdepression |
| spellingShingle | Oana-Maria Nicola (Marioara) Alice Elena Ghenea Cristina-Nicoleta Vlădoianu Mara Carsote Mihaela Popescu The relationship between serotonine, histamine and the brain`s electrical activity in patients with depression and endocrine disorders Romanian Medical Journal serotonine histamine eeg depression |
| title | The relationship between serotonine, histamine and the brain`s electrical activity in patients with depression and endocrine disorders |
| title_full | The relationship between serotonine, histamine and the brain`s electrical activity in patients with depression and endocrine disorders |
| title_fullStr | The relationship between serotonine, histamine and the brain`s electrical activity in patients with depression and endocrine disorders |
| title_full_unstemmed | The relationship between serotonine, histamine and the brain`s electrical activity in patients with depression and endocrine disorders |
| title_short | The relationship between serotonine, histamine and the brain`s electrical activity in patients with depression and endocrine disorders |
| title_sort | relationship between serotonine histamine and the brain s electrical activity in patients with depression and endocrine disorders |
| topic | serotonine histamine eeg depression |
| url | https://rmj.com.ro/articles/2021.2/RMJ_2021_2_Art-22.pdf |
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