Longitudinal follow-up of the asthma status in a French–Canadian cohort
Abstract Asthma affects 340 million people worldwide and varies in time. Twenty years ago, in Canada, the Saguenay–Lac-Saint-Jean asthma family cohort was created to study the genetic and environmental components of asthma. This study is a follow-up of 125 participants of this cohort to explore the...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-08-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-17959-6 |
| _version_ | 1798042493680353280 |
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| author | Marie-Eve Lavoie Jolyane Meloche Anne-Marie Boucher-Lafleur Paul Bégin Charles Morin Louis-Philippe Boulet Anne-Marie Madore Catherine Laprise |
| author_facet | Marie-Eve Lavoie Jolyane Meloche Anne-Marie Boucher-Lafleur Paul Bégin Charles Morin Louis-Philippe Boulet Anne-Marie Madore Catherine Laprise |
| author_sort | Marie-Eve Lavoie |
| collection | DOAJ |
| description | Abstract Asthma affects 340 million people worldwide and varies in time. Twenty years ago, in Canada, the Saguenay–Lac-Saint-Jean asthma family cohort was created to study the genetic and environmental components of asthma. This study is a follow-up of 125 participants of this cohort to explore the appearance, persistence, and progression of asthma over 10–20 years. Participants answered a clinical standardized questionnaire. Lung function was assessed (forced expiratory volume in 1 s, forced vital capacity, bronchial reversibility, and methacholine bronchoprovocation), skin allergy testing was performed, blood samples were obtained (immunoglobulin E, white blood cell counts) and phenotypes were compared between recruitment and follow-up. From the participants without asthma at recruitment, 12% developed a phenotype of adult-onset asthma with the presence of risk factors, such as atopy, high body mass index, and exposure to smoking. A decrease of PC20 values in this group was observed and a decrease in the FEV1/FVC ratio in all groups. Also, 7% of individuals with asthma at recruitment developed chronic obstructive pulmonary disease, presenting risk factors at recruitment, such as moderate-to-severe bronchial hyperresponsiveness, exposure to smoking, and asthma. This study allowed a better interpretation of the evolution of asthma. Fine phenotypic characterization is the first step for meaningful genetic and epigenetic studies. |
| first_indexed | 2024-04-11T22:36:17Z |
| format | Article |
| id | doaj.art-ebe0ff15f8c64cc7aaed3187b3f5348b |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-11T22:36:17Z |
| publishDate | 2022-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-ebe0ff15f8c64cc7aaed3187b3f5348b2022-12-22T03:59:13ZengNature PortfolioScientific Reports2045-23222022-08-0112111010.1038/s41598-022-17959-6Longitudinal follow-up of the asthma status in a French–Canadian cohortMarie-Eve Lavoie0Jolyane Meloche1Anne-Marie Boucher-Lafleur2Paul Bégin3Charles Morin4Louis-Philippe Boulet5Anne-Marie Madore6Catherine Laprise7Centre Intersectoriel en Santé Durable, Université du Québec à ChicoutimiCentre Intersectoriel en Santé Durable, Université du Québec à ChicoutimiCentre Intersectoriel en Santé Durable, Université du Québec à ChicoutimiCentre Intégré Universitaire en Santé et Services Sociaux du Saguenay–Lac-Saint-JeanCentre Intégré Universitaire en Santé et Services Sociaux du Saguenay–Lac-Saint-JeanCentre de Recherche de l’Institut Universitaire de Cardiologie et de Pneumologie de Québec (CRIUCPQ), Université LavalCentre Intersectoriel en Santé Durable, Université du Québec à ChicoutimiCentre Intersectoriel en Santé Durable, Université du Québec à ChicoutimiAbstract Asthma affects 340 million people worldwide and varies in time. Twenty years ago, in Canada, the Saguenay–Lac-Saint-Jean asthma family cohort was created to study the genetic and environmental components of asthma. This study is a follow-up of 125 participants of this cohort to explore the appearance, persistence, and progression of asthma over 10–20 years. Participants answered a clinical standardized questionnaire. Lung function was assessed (forced expiratory volume in 1 s, forced vital capacity, bronchial reversibility, and methacholine bronchoprovocation), skin allergy testing was performed, blood samples were obtained (immunoglobulin E, white blood cell counts) and phenotypes were compared between recruitment and follow-up. From the participants without asthma at recruitment, 12% developed a phenotype of adult-onset asthma with the presence of risk factors, such as atopy, high body mass index, and exposure to smoking. A decrease of PC20 values in this group was observed and a decrease in the FEV1/FVC ratio in all groups. Also, 7% of individuals with asthma at recruitment developed chronic obstructive pulmonary disease, presenting risk factors at recruitment, such as moderate-to-severe bronchial hyperresponsiveness, exposure to smoking, and asthma. This study allowed a better interpretation of the evolution of asthma. Fine phenotypic characterization is the first step for meaningful genetic and epigenetic studies.https://doi.org/10.1038/s41598-022-17959-6 |
| spellingShingle | Marie-Eve Lavoie Jolyane Meloche Anne-Marie Boucher-Lafleur Paul Bégin Charles Morin Louis-Philippe Boulet Anne-Marie Madore Catherine Laprise Longitudinal follow-up of the asthma status in a French–Canadian cohort Scientific Reports |
| title | Longitudinal follow-up of the asthma status in a French–Canadian cohort |
| title_full | Longitudinal follow-up of the asthma status in a French–Canadian cohort |
| title_fullStr | Longitudinal follow-up of the asthma status in a French–Canadian cohort |
| title_full_unstemmed | Longitudinal follow-up of the asthma status in a French–Canadian cohort |
| title_short | Longitudinal follow-up of the asthma status in a French–Canadian cohort |
| title_sort | longitudinal follow up of the asthma status in a french canadian cohort |
| url | https://doi.org/10.1038/s41598-022-17959-6 |
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