A conserved function of Human DLC3 and Drosophila Cv-c in testis development

A conserved function of Human DLC3 and Drosophila Cv-c in testis development

The identification of genes affecting gonad development is essential to understand the mechanisms causing Variations/Differences in Sex Development (DSD). Recently, a DLC3 mutation was associated with male gonadal dysgenesis in 46,XY DSD patients. We have studied the requirement of Cv-c, the Drosoph...

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Main Authors: Sol Sotillos, Isabel von der Decken, Ivan Domenech Mercadé, Sriraksha Srinivasan, Dmytro Sirokha, Ludmila Livshits, Stefano Vanni, Serge Nef, Anna Biason-Lauber, Daniel Rodríguez Gutiérrez, James Castelli-Gair Hombría
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-11-01
Series:eLife
Subjects:
46,XY gonadal dysgenesis
human gonadogenesis
Drosophila testis
deleted in liver cancer/Cv-c
StART-RhoGAP domain
Online Access:https://elifesciences.org/articles/82343

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