Circulating miRNAs: cell-cell communication function?
Nuclease resistant extracellular miRNAs have been found in all known biological fluids. The biological function of extracellular miRNAs remains questionable; however, strong evidence suggests that these miRNAs can be more than just byproducts of cellular activity. Some extracellular miRNA species mi...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-06-01
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| Series: | Frontiers in Genetics |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fgene.2013.00119/full |
| _version_ | 1818147517236248576 |
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| author | Andrey eTurchinovich Andrey eTurchinovich Timur R Samatov Alexander G Tonevitsky Alexander G Tonevitsky Barbara eBurwinkel Barbara eBurwinkel |
| author_facet | Andrey eTurchinovich Andrey eTurchinovich Timur R Samatov Alexander G Tonevitsky Alexander G Tonevitsky Barbara eBurwinkel Barbara eBurwinkel |
| author_sort | Andrey eTurchinovich |
| collection | DOAJ |
| description | Nuclease resistant extracellular miRNAs have been found in all known biological fluids. The biological function of extracellular miRNAs remains questionable; however, strong evidence suggests that these miRNAs can be more than just byproducts of cellular activity. Some extracellular miRNA species might carry cell-cell signaling function during various physiological and pathological processes. In this review, we discuss the state-of-the-art in the field of intercellular miRNA transport and highlight current theories regarding the origin and the biological function of extracellular miRNAs. |
| first_indexed | 2024-12-11T12:36:30Z |
| format | Article |
| id | doaj.art-ebe1caea3a1c45faad7a934269e376da |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-12-11T12:36:30Z |
| publishDate | 2013-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-ebe1caea3a1c45faad7a934269e376da2022-12-22T01:07:07ZengFrontiers Media S.A.Frontiers in Genetics1664-80212013-06-01410.3389/fgene.2013.0011953855Circulating miRNAs: cell-cell communication function?Andrey eTurchinovich0Andrey eTurchinovich1Timur R Samatov2Alexander G Tonevitsky3Alexander G Tonevitsky4Barbara eBurwinkel5Barbara eBurwinkel6German Cancer Research Center (DKFZ)University Clinic HeidelbergSCR BioclinicumM.V. Lomonosov Moscow State UniversityInstitute of General Pathology and PathophysiologyGerman Cancer Research Center (DKFZ)University Clinic HeidelbergNuclease resistant extracellular miRNAs have been found in all known biological fluids. The biological function of extracellular miRNAs remains questionable; however, strong evidence suggests that these miRNAs can be more than just byproducts of cellular activity. Some extracellular miRNA species might carry cell-cell signaling function during various physiological and pathological processes. In this review, we discuss the state-of-the-art in the field of intercellular miRNA transport and highlight current theories regarding the origin and the biological function of extracellular miRNAs.http://journal.frontiersin.org/Journal/10.3389/fgene.2013.00119/fullArgonaute ProteinsCell CommunicationExosomesmiRNAbiomarkersMicrovesicles |
| spellingShingle | Andrey eTurchinovich Andrey eTurchinovich Timur R Samatov Alexander G Tonevitsky Alexander G Tonevitsky Barbara eBurwinkel Barbara eBurwinkel Circulating miRNAs: cell-cell communication function? Frontiers in Genetics Argonaute Proteins Cell Communication Exosomes miRNA biomarkers Microvesicles |
| title | Circulating miRNAs: cell-cell communication function? |
| title_full | Circulating miRNAs: cell-cell communication function? |
| title_fullStr | Circulating miRNAs: cell-cell communication function? |
| title_full_unstemmed | Circulating miRNAs: cell-cell communication function? |
| title_short | Circulating miRNAs: cell-cell communication function? |
| title_sort | circulating mirnas cell cell communication function |
| topic | Argonaute Proteins Cell Communication Exosomes miRNA biomarkers Microvesicles |
| url | http://journal.frontiersin.org/Journal/10.3389/fgene.2013.00119/full |
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