Hypoxia regulates adipose mesenchymal stem cells proliferation, migration, and nucleus pulposus-like differentiation by regulating endoplasmic reticulum stress via the HIF-1α pathway

Hypoxia regulates adipose mesenchymal stem cells proliferation, migration, and nucleus pulposus-like differentiation by regulating endoplasmic reticulum stress via the HIF-1α pathway

Abstract Objective Hypoxia can promote stem cell proliferation and migration through HIF-1α. Hypoxia can regulate cellular endoplasmic reticulum (ER) stress. Some studies have reported the relationship among hypoxia, HIF-α, and ER stress, however, while little is known about HIF-α and ER stress in A...

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Bibliographic Details
Main Authors: Jianxin Wu, Lei Yu, Yi Liu, Bing Xiao, Xiaojian Ye, Hong Zhao, Yanhai Xi, Zhicai Shi, Weiheng Wang
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Hypoxia
HIF-1α
Migration
Proliferation
ADSCs
Directional differentiation
Online Access:https://doi.org/10.1186/s13018-023-03818-1

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