Biological System Responses of Dairy Cows to Aflatoxin B1 Exposure Revealed with Metabolomic Changes in Multiple Biofluids
Research on mycotoxins now requires a systematic study of post-exposure organisms. In this study, the effects of aflatoxin B1 (AFB1) on biofluids biomarkers were examined with metabolomics and biochemical tests. The results showed that milk concentration of aflatoxin M1 changed with the addition or...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-02-01
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| Series: | Toxins |
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| Online Access: | https://www.mdpi.com/2072-6651/11/2/77 |
| _version_ | 1828349051993587712 |
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| author | Qian Wang Yangdong Zhang Nan Zheng Liya Guo Xiaoming Song Shengguo Zhao Jiaqi Wang |
| author_facet | Qian Wang Yangdong Zhang Nan Zheng Liya Guo Xiaoming Song Shengguo Zhao Jiaqi Wang |
| author_sort | Qian Wang |
| collection | DOAJ |
| description | Research on mycotoxins now requires a systematic study of post-exposure organisms. In this study, the effects of aflatoxin B1 (AFB1) on biofluids biomarkers were examined with metabolomics and biochemical tests. The results showed that milk concentration of aflatoxin M1 changed with the addition or removal of AFB1. AFB1 significantly affected serum concentrations of superoxide dismutase (SOD) and malon dialdehyde (MDA), SOD/MDA, and the total antioxidant capacity. Significant differences of volatile fatty acids and NH<sub>3</sub>-N were detected in the rumen fluid. Eighteen rumen fluid metabolites, 11 plasma metabolites, and 9 milk metabolites were significantly affected by the AFB1. These metabolites are mainly involved in the pathway of amino acids metabolism. Our results suggest that not only is the study of macro-indicators (milk composition and production) important, but that more attention should be paid to micro-indicators (biomarkers) when assessing the risks posed by mycotoxins to dairy cows. |
| first_indexed | 2024-04-14T01:03:48Z |
| format | Article |
| id | doaj.art-ebe288ab640f414f8cd354b624df5660 |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-04-14T01:03:48Z |
| publishDate | 2019-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-ebe288ab640f414f8cd354b624df56602022-12-22T02:21:19ZengMDPI AGToxins2072-66512019-02-011127710.3390/toxins11020077toxins11020077Biological System Responses of Dairy Cows to Aflatoxin B1 Exposure Revealed with Metabolomic Changes in Multiple BiofluidsQian Wang0Yangdong Zhang1Nan Zheng2Liya Guo3Xiaoming Song4Shengguo Zhao5Jiaqi Wang6State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, ChinaState Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, ChinaState Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, ChinaState Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, ChinaState Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, ChinaState Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, ChinaState Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, ChinaResearch on mycotoxins now requires a systematic study of post-exposure organisms. In this study, the effects of aflatoxin B1 (AFB1) on biofluids biomarkers were examined with metabolomics and biochemical tests. The results showed that milk concentration of aflatoxin M1 changed with the addition or removal of AFB1. AFB1 significantly affected serum concentrations of superoxide dismutase (SOD) and malon dialdehyde (MDA), SOD/MDA, and the total antioxidant capacity. Significant differences of volatile fatty acids and NH<sub>3</sub>-N were detected in the rumen fluid. Eighteen rumen fluid metabolites, 11 plasma metabolites, and 9 milk metabolites were significantly affected by the AFB1. These metabolites are mainly involved in the pathway of amino acids metabolism. Our results suggest that not only is the study of macro-indicators (milk composition and production) important, but that more attention should be paid to micro-indicators (biomarkers) when assessing the risks posed by mycotoxins to dairy cows.https://www.mdpi.com/2072-6651/11/2/77aflatoxin B1biofluidmetabolomicsdairy cow |
| spellingShingle | Qian Wang Yangdong Zhang Nan Zheng Liya Guo Xiaoming Song Shengguo Zhao Jiaqi Wang Biological System Responses of Dairy Cows to Aflatoxin B1 Exposure Revealed with Metabolomic Changes in Multiple Biofluids Toxins aflatoxin B1 biofluid metabolomics dairy cow |
| title | Biological System Responses of Dairy Cows to Aflatoxin B1 Exposure Revealed with Metabolomic Changes in Multiple Biofluids |
| title_full | Biological System Responses of Dairy Cows to Aflatoxin B1 Exposure Revealed with Metabolomic Changes in Multiple Biofluids |
| title_fullStr | Biological System Responses of Dairy Cows to Aflatoxin B1 Exposure Revealed with Metabolomic Changes in Multiple Biofluids |
| title_full_unstemmed | Biological System Responses of Dairy Cows to Aflatoxin B1 Exposure Revealed with Metabolomic Changes in Multiple Biofluids |
| title_short | Biological System Responses of Dairy Cows to Aflatoxin B1 Exposure Revealed with Metabolomic Changes in Multiple Biofluids |
| title_sort | biological system responses of dairy cows to aflatoxin b1 exposure revealed with metabolomic changes in multiple biofluids |
| topic | aflatoxin B1 biofluid metabolomics dairy cow |
| url | https://www.mdpi.com/2072-6651/11/2/77 |
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