Cardiovascular Comorbidities in Relation to the Functional Status and Vitamin D Levels in Elderly Patients with Dementia
(1) Background: As dementia is an incurable, multifactorial neurodegenerative disease, we gathered and analyzed a number of patient characteristics, assessing possible correlations that may support early diagnosis and a more accurate prognosis for cognitively impaired patients. (2) Methods: We used...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/12/12/2994 |
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| author | Violeta Diana Oprea Mihai Marinescu Corina Rișcă Popazu Fabiola Sârbu Gelu Onose Aurelia Romila |
| author_facet | Violeta Diana Oprea Mihai Marinescu Corina Rișcă Popazu Fabiola Sârbu Gelu Onose Aurelia Romila |
| author_sort | Violeta Diana Oprea |
| collection | DOAJ |
| description | (1) Background: As dementia is an incurable, multifactorial neurodegenerative disease, we gathered and analyzed a number of patient characteristics, assessing possible correlations that may support early diagnosis and a more accurate prognosis for cognitively impaired patients. (2) Methods: We used standard clinical parameters (cognitive and functional status, comorbidities, and plasma vitamin D levels) in a study group of 162 patients aged above 55 years old. (3) Results: We reported a higher incidence of cardiovascular and metabolic comorbidities in patients with severe or moderate cognitive impairment; a validated correlation between functional status, cognitive status, and serum vitamin D levels; and a more frequently associated profile of neurologic comorbidities in patients with a more significant cognitive deficiency. (4) Conclusions: The present research adds data on the significant correlations of cognitive deficits with cardiovascular, metabolic, and neurologic diseases (and the lack of correlation with osteoarticular illness). Clinicians should make the best use of the current screening and assessment tools (such as the functional scoring of daily activities, cognitive evaluation, and the screening of risk factors). Our data may offer starting points for future in-depth analysis of dementia-modifiable risk factors. |
| first_indexed | 2024-03-09T17:08:51Z |
| format | Article |
| id | doaj.art-ebe2ffcbf55f40b5bcc53b120eea0f6e |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-09T17:08:51Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-ebe2ffcbf55f40b5bcc53b120eea0f6e2023-11-24T14:16:49ZengMDPI AGDiagnostics2075-44182022-11-011212299410.3390/diagnostics12122994Cardiovascular Comorbidities in Relation to the Functional Status and Vitamin D Levels in Elderly Patients with DementiaVioleta Diana Oprea0Mihai Marinescu1Corina Rișcă Popazu2Fabiola Sârbu3Gelu Onose4Aurelia Romila5Faculty of Medicine and Pharmacy, “Dunărea de Jos” University, 800216 Galați, RomaniaFaculty of Medicine and Pharmacy, “Dunărea de Jos” University, 800216 Galați, RomaniaFaculty of Medicine and Pharmacy, “Dunărea de Jos” University, 800216 Galați, RomaniaFaculty of Medicine and Pharmacy, “Dunărea de Jos” University, 800216 Galați, RomaniaDepartment of Physical and Rehabilitation Medicine, Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy in Bucharest, 020021 Bucharest, RomaniaFaculty of Medicine and Pharmacy, “Dunărea de Jos” University, 800216 Galați, Romania(1) Background: As dementia is an incurable, multifactorial neurodegenerative disease, we gathered and analyzed a number of patient characteristics, assessing possible correlations that may support early diagnosis and a more accurate prognosis for cognitively impaired patients. (2) Methods: We used standard clinical parameters (cognitive and functional status, comorbidities, and plasma vitamin D levels) in a study group of 162 patients aged above 55 years old. (3) Results: We reported a higher incidence of cardiovascular and metabolic comorbidities in patients with severe or moderate cognitive impairment; a validated correlation between functional status, cognitive status, and serum vitamin D levels; and a more frequently associated profile of neurologic comorbidities in patients with a more significant cognitive deficiency. (4) Conclusions: The present research adds data on the significant correlations of cognitive deficits with cardiovascular, metabolic, and neurologic diseases (and the lack of correlation with osteoarticular illness). Clinicians should make the best use of the current screening and assessment tools (such as the functional scoring of daily activities, cognitive evaluation, and the screening of risk factors). Our data may offer starting points for future in-depth analysis of dementia-modifiable risk factors.https://www.mdpi.com/2075-4418/12/12/2994dementiacognitive declinecardiovascular riskfunctional statusdepressionvitamin D deficiency |
| spellingShingle | Violeta Diana Oprea Mihai Marinescu Corina Rișcă Popazu Fabiola Sârbu Gelu Onose Aurelia Romila Cardiovascular Comorbidities in Relation to the Functional Status and Vitamin D Levels in Elderly Patients with Dementia Diagnostics dementia cognitive decline cardiovascular risk functional status depression vitamin D deficiency |
| title | Cardiovascular Comorbidities in Relation to the Functional Status and Vitamin D Levels in Elderly Patients with Dementia |
| title_full | Cardiovascular Comorbidities in Relation to the Functional Status and Vitamin D Levels in Elderly Patients with Dementia |
| title_fullStr | Cardiovascular Comorbidities in Relation to the Functional Status and Vitamin D Levels in Elderly Patients with Dementia |
| title_full_unstemmed | Cardiovascular Comorbidities in Relation to the Functional Status and Vitamin D Levels in Elderly Patients with Dementia |
| title_short | Cardiovascular Comorbidities in Relation to the Functional Status and Vitamin D Levels in Elderly Patients with Dementia |
| title_sort | cardiovascular comorbidities in relation to the functional status and vitamin d levels in elderly patients with dementia |
| topic | dementia cognitive decline cardiovascular risk functional status depression vitamin D deficiency |
| url | https://www.mdpi.com/2075-4418/12/12/2994 |
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