Low-dose adenosine stress echocardiography: Detection of myocardial viability
<p>Abstract</p> <p>Objective</p> <p>The aim of this study was to evaluate the diagnostic potential of low-dose adenosine stress echocardiography in detection of myocardial viability.</p> <p>Background</p> <p>Vasodilation through low dose dipyrida...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2003-06-01
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| Series: | Cardiovascular Ultrasound |
| Subjects: | |
| Online Access: | http://www.cardiovascularultrasound.com/content/1/1/7 |
| _version_ | 1828405613070123008 |
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| author | Nedeljkovic Milan Petrasinovic Zorica Stojkovic Sinisa Stepanovic Jelena Nedeljkovic Ivana Beleslin Branko Ostojic Miodrag Djordjevic-Dikic Ana Saponjski Jovica Giga Vojislav |
| author_facet | Nedeljkovic Milan Petrasinovic Zorica Stojkovic Sinisa Stepanovic Jelena Nedeljkovic Ivana Beleslin Branko Ostojic Miodrag Djordjevic-Dikic Ana Saponjski Jovica Giga Vojislav |
| author_sort | Nedeljkovic Milan |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Objective</p> <p>The aim of this study was to evaluate the diagnostic potential of low-dose adenosine stress echocardiography in detection of myocardial viability.</p> <p>Background</p> <p>Vasodilation through low dose dipyridamole infusion may recruit contractile reserve by increasing coronary flow or by increasing levels of endogenous adenosine.</p> <p>Methods</p> <p>Forty-three patients with resting dyssynergy, due to previous myocardial infarction, underwent low-dose adenosine (80, 100, 110 mcg/kg/min in 3 minutes intervals) echocardiography test. Gold standard for myocardial viability was improvement in systolic thickening of dyssinergic segments of ≥ 1 grade at follow-up. Coronary angiography was done in 41 pts. Twenty-seven patients were revascularized and 16 were medically treated. Echocardiographic follow up data (12 ± 2 months) were available in 24 revascularized patients.</p> <p>Results</p> <p>Wall motion score index improved from rest 1.55 ± 0.30 to 1.33 ± 0.26 at low-dose adenosine (p < 0.001). Of the 257 segments with baseline dyssynergy, adenosine echocardiography identified 122 segments as positive for viability, and 135 as necrotic since no improvement of systolic thickening was observed. Follow-up wall motion score index was 1.31 ± 0.30 (p < 0.001 vs. rest). The sensitivity of adenosine echo test for identification of viable segments was 87%, while specificity was 95%, and diagnostic accuracy 90%. Positive and negative predictive values were 97% and 80%, respectively.</p> <p>Conclusion</p> <p>Low-dose adenosine stress echocardiography test has high diagnostic potential for detection of myocardial viability in the group of patients with left ventricle dysfunction due to previous myocardial infarction. Low dose adenosine stress echocardiography may be adequate alternative to low-dose dobutamine test for evaluation of myocardial viability.</p> |
| first_indexed | 2024-12-10T10:56:25Z |
| format | Article |
| id | doaj.art-ebe476349c2f42bbb278572e5d757d3d |
| institution | Directory Open Access Journal |
| issn | 1476-7120 |
| language | English |
| last_indexed | 2024-12-10T10:56:25Z |
| publishDate | 2003-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Cardiovascular Ultrasound |
| spelling | doaj.art-ebe476349c2f42bbb278572e5d757d3d2022-12-22T01:51:51ZengBMCCardiovascular Ultrasound1476-71202003-06-0111710.1186/1476-7120-1-7Low-dose adenosine stress echocardiography: Detection of myocardial viabilityNedeljkovic MilanPetrasinovic ZoricaStojkovic SinisaStepanovic JelenaNedeljkovic IvanaBeleslin BrankoOstojic MiodragDjordjevic-Dikic AnaSaponjski JovicaGiga Vojislav<p>Abstract</p> <p>Objective</p> <p>The aim of this study was to evaluate the diagnostic potential of low-dose adenosine stress echocardiography in detection of myocardial viability.</p> <p>Background</p> <p>Vasodilation through low dose dipyridamole infusion may recruit contractile reserve by increasing coronary flow or by increasing levels of endogenous adenosine.</p> <p>Methods</p> <p>Forty-three patients with resting dyssynergy, due to previous myocardial infarction, underwent low-dose adenosine (80, 100, 110 mcg/kg/min in 3 minutes intervals) echocardiography test. Gold standard for myocardial viability was improvement in systolic thickening of dyssinergic segments of ≥ 1 grade at follow-up. Coronary angiography was done in 41 pts. Twenty-seven patients were revascularized and 16 were medically treated. Echocardiographic follow up data (12 ± 2 months) were available in 24 revascularized patients.</p> <p>Results</p> <p>Wall motion score index improved from rest 1.55 ± 0.30 to 1.33 ± 0.26 at low-dose adenosine (p < 0.001). Of the 257 segments with baseline dyssynergy, adenosine echocardiography identified 122 segments as positive for viability, and 135 as necrotic since no improvement of systolic thickening was observed. Follow-up wall motion score index was 1.31 ± 0.30 (p < 0.001 vs. rest). The sensitivity of adenosine echo test for identification of viable segments was 87%, while specificity was 95%, and diagnostic accuracy 90%. Positive and negative predictive values were 97% and 80%, respectively.</p> <p>Conclusion</p> <p>Low-dose adenosine stress echocardiography test has high diagnostic potential for detection of myocardial viability in the group of patients with left ventricle dysfunction due to previous myocardial infarction. Low dose adenosine stress echocardiography may be adequate alternative to low-dose dobutamine test for evaluation of myocardial viability.</p>http://www.cardiovascularultrasound.com/content/1/1/7Adenosinestress echocardiographymyocardial viability |
| spellingShingle | Nedeljkovic Milan Petrasinovic Zorica Stojkovic Sinisa Stepanovic Jelena Nedeljkovic Ivana Beleslin Branko Ostojic Miodrag Djordjevic-Dikic Ana Saponjski Jovica Giga Vojislav Low-dose adenosine stress echocardiography: Detection of myocardial viability Cardiovascular Ultrasound Adenosine stress echocardiography myocardial viability |
| title | Low-dose adenosine stress echocardiography: Detection of myocardial viability |
| title_full | Low-dose adenosine stress echocardiography: Detection of myocardial viability |
| title_fullStr | Low-dose adenosine stress echocardiography: Detection of myocardial viability |
| title_full_unstemmed | Low-dose adenosine stress echocardiography: Detection of myocardial viability |
| title_short | Low-dose adenosine stress echocardiography: Detection of myocardial viability |
| title_sort | low dose adenosine stress echocardiography detection of myocardial viability |
| topic | Adenosine stress echocardiography myocardial viability |
| url | http://www.cardiovascularultrasound.com/content/1/1/7 |
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