Métodos de obtenção, reatividade e importância biológica de 4-tiazolidinonas Preparation methods, reactivity and biological importance of 4-thiazolidinones
<abstract language="eng">Molecules containing the 4-thiazolidinone ring are known to possess a wide range of biological properties including antimicrobial and anti-inflammatory activities among others. These compounds can be synthesized by cyclization reactions involving alpha-haloac...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Sociedade Brasileira de Química
2008-01-01
|
| Series: | Química Nova |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000200033 |
| _version_ | 1819181342162681856 |
|---|---|
| author | André P. Liesen Thiago M. de Aquino Alexandre J. S. Góes José G. de Lima Antônio R. de Faria Antonio J. Alves |
| author_facet | André P. Liesen Thiago M. de Aquino Alexandre J. S. Góes José G. de Lima Antônio R. de Faria Antonio J. Alves |
| author_sort | André P. Liesen |
| collection | DOAJ |
| description | <abstract language="eng">Molecules containing the 4-thiazolidinone ring are known to possess a wide range of biological properties including antimicrobial and anti-inflammatory activities among others. These compounds can be synthesized by cyclization reactions involving alpha-haloacetic acid or alpha-mercaptoacetic acid and employed in several chemoselective reactions. Comprehensive reviews have been written on 4-thiazolidinones in 1961 by Brown and in 1980 by Singh et al. In the recent literature, some new synthesis methods for 4-thiazolidinone derivatives and several reactions have been reported. These advances warrant to review the chemical and biological properties of compounds with this important heterocycle employed in synthetic organic chemistry and medicinal chemistry. |
| first_indexed | 2024-12-22T22:28:42Z |
| format | Article |
| id | doaj.art-ebe479e4cd174aa0a5a98f23aeda83d6 |
| institution | Directory Open Access Journal |
| issn | 0100-4042 1678-7064 |
| language | English |
| last_indexed | 2024-12-22T22:28:42Z |
| publishDate | 2008-01-01 |
| publisher | Sociedade Brasileira de Química |
| record_format | Article |
| series | Química Nova |
| spelling | doaj.art-ebe479e4cd174aa0a5a98f23aeda83d62022-12-21T18:10:30ZengSociedade Brasileira de QuímicaQuímica Nova0100-40421678-70642008-01-0131236937610.1590/S0100-40422008000200033Métodos de obtenção, reatividade e importância biológica de 4-tiazolidinonas Preparation methods, reactivity and biological importance of 4-thiazolidinonesAndré P. LiesenThiago M. de AquinoAlexandre J. S. GóesJosé G. de LimaAntônio R. de FariaAntonio J. Alves<abstract language="eng">Molecules containing the 4-thiazolidinone ring are known to possess a wide range of biological properties including antimicrobial and anti-inflammatory activities among others. These compounds can be synthesized by cyclization reactions involving alpha-haloacetic acid or alpha-mercaptoacetic acid and employed in several chemoselective reactions. Comprehensive reviews have been written on 4-thiazolidinones in 1961 by Brown and in 1980 by Singh et al. In the recent literature, some new synthesis methods for 4-thiazolidinone derivatives and several reactions have been reported. These advances warrant to review the chemical and biological properties of compounds with this important heterocycle employed in synthetic organic chemistry and medicinal chemistry.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-404220080002000334-thiazolidinonepreparation methodsreactivity |
| spellingShingle | André P. Liesen Thiago M. de Aquino Alexandre J. S. Góes José G. de Lima Antônio R. de Faria Antonio J. Alves Métodos de obtenção, reatividade e importância biológica de 4-tiazolidinonas Preparation methods, reactivity and biological importance of 4-thiazolidinones Química Nova 4-thiazolidinone preparation methods reactivity |
| title | Métodos de obtenção, reatividade e importância biológica de 4-tiazolidinonas Preparation methods, reactivity and biological importance of 4-thiazolidinones |
| title_full | Métodos de obtenção, reatividade e importância biológica de 4-tiazolidinonas Preparation methods, reactivity and biological importance of 4-thiazolidinones |
| title_fullStr | Métodos de obtenção, reatividade e importância biológica de 4-tiazolidinonas Preparation methods, reactivity and biological importance of 4-thiazolidinones |
| title_full_unstemmed | Métodos de obtenção, reatividade e importância biológica de 4-tiazolidinonas Preparation methods, reactivity and biological importance of 4-thiazolidinones |
| title_short | Métodos de obtenção, reatividade e importância biológica de 4-tiazolidinonas Preparation methods, reactivity and biological importance of 4-thiazolidinones |
| title_sort | metodos de obtencao reatividade e importancia biologica de 4 tiazolidinonas preparation methods reactivity and biological importance of 4 thiazolidinones |
| topic | 4-thiazolidinone preparation methods reactivity |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000200033 |
| work_keys_str_mv | AT andrepliesen metodosdeobtencaoreatividadeeimportanciabiologicade4tiazolidinonaspreparationmethodsreactivityandbiologicalimportanceof4thiazolidinones AT thiagomdeaquino metodosdeobtencaoreatividadeeimportanciabiologicade4tiazolidinonaspreparationmethodsreactivityandbiologicalimportanceof4thiazolidinones AT alexandrejsgoes metodosdeobtencaoreatividadeeimportanciabiologicade4tiazolidinonaspreparationmethodsreactivityandbiologicalimportanceof4thiazolidinones AT josegdelima metodosdeobtencaoreatividadeeimportanciabiologicade4tiazolidinonaspreparationmethodsreactivityandbiologicalimportanceof4thiazolidinones AT antoniordefaria metodosdeobtencaoreatividadeeimportanciabiologicade4tiazolidinonaspreparationmethodsreactivityandbiologicalimportanceof4thiazolidinones AT antoniojalves metodosdeobtencaoreatividadeeimportanciabiologicade4tiazolidinonaspreparationmethodsreactivityandbiologicalimportanceof4thiazolidinones |