Neighborhood Socioeconomic Disadvantage and White Matter Microstructure of the Arcuate Fasciculus and Uncinate Fasciculus in Adolescents
Background: Neighborhood- or area-level socioeconomic disadvantage is associated with neural alterations across the life span. However, few studies have examined the effects of neighborhood disadvantage on white matter microstructure during adolescence, an important period of development that coinci...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Biological Psychiatry Global Open Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667174323001404 |
| _version_ | 1797449461135310848 |
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| author | Artenisa Kulla Saché Coury Jordan M. Garcia Giana I. Teresi Lucinda M. Sisk Melissa Hansen Jonas G. Miller Ian H. Gotlib Tiffany C. Ho |
| author_facet | Artenisa Kulla Saché Coury Jordan M. Garcia Giana I. Teresi Lucinda M. Sisk Melissa Hansen Jonas G. Miller Ian H. Gotlib Tiffany C. Ho |
| author_sort | Artenisa Kulla |
| collection | DOAJ |
| description | Background: Neighborhood- or area-level socioeconomic disadvantage is associated with neural alterations across the life span. However, few studies have examined the effects of neighborhood disadvantage on white matter microstructure during adolescence, an important period of development that coincides with increased risk for psychopathology. Methods: In 200 adolescents (ages 13–20 years; 54.5% female, 4% nonbinary) recruited from 2 studies enriched for early adversity and depression, we examined whether neighborhood socioeconomic disadvantage derived from census tract data was related to white matter microstructure in several major white matter tracts. We also examined whether depressive symptoms and sex moderated these associations. Results: Greater neighborhood socioeconomic disadvantage was associated with lower fractional anisotropy (FA) in the left arcuate fasciculus (β = −0.24, false discovery rate [FDR]–corrected p = .035) and right uncinate fasciculus (β = −0.32, FDR-corrected p = .002) above and beyond the effects of family-level socioeconomic status. Depressive symptoms significantly moderated the association between left arcuate fasciculus FA and both neighborhood (β = 0.17, FDR-corrected p = .026) and unemployment (β = 0.22, FDR-corrected p = .004) disadvantage such that these associations were only significant in adolescents who reported less severe depression. Sex did not moderate the association between socioeconomic disadvantage and FA in these tracts. Conclusions: Greater neighborhood socioeconomic disadvantage, particularly poverty and educational attainment levels, was associated with lower FA in the arcuate fasciculus and uncinate fasciculus above and beyond the effects of family-level measures of socioeconomic status. These patterns were only observed in adolescents with low levels of depression, suggesting that we must be cautious about generalizing these findings to youths who struggle with mental health difficulties. |
| first_indexed | 2024-03-09T14:25:22Z |
| format | Article |
| id | doaj.art-ebe6ae5622eb4e0f8607477860791eee |
| institution | Directory Open Access Journal |
| issn | 2667-1743 |
| language | English |
| last_indexed | 2024-03-09T14:25:22Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biological Psychiatry Global Open Science |
| spelling | doaj.art-ebe6ae5622eb4e0f8607477860791eee2023-11-28T07:27:15ZengElsevierBiological Psychiatry Global Open Science2667-17432024-01-01416172Neighborhood Socioeconomic Disadvantage and White Matter Microstructure of the Arcuate Fasciculus and Uncinate Fasciculus in AdolescentsArtenisa Kulla0Saché Coury1Jordan M. Garcia2Giana I. Teresi3Lucinda M. Sisk4Melissa Hansen5Jonas G. Miller6Ian H. Gotlib7Tiffany C. Ho8College of Medicine, University of Florida, Gainesville, FloridaDepartment of Psychology, Stanford University, Stanford, CaliforniaDepartment of Psychology, Stanford University, Stanford, CaliforniaDepartment of Psychology, University of Pittsburgh, Pittsburgh, PennsylvaniaDepartment of Psychology, Yale University, New Haven, ConnecticutDepartment of Psychology, Colorado State University, Fort Collins, ColoradoDepartment of Psychological Sciences, University of Connecticut, Storrs, ConnecticutDepartment of Psychology, Stanford University, Stanford, CaliforniaDepartment of Psychology, University of California, Los Angeles, Los Angeles, California; Address correspondence to Tiffany C. Ho, Ph.D.Background: Neighborhood- or area-level socioeconomic disadvantage is associated with neural alterations across the life span. However, few studies have examined the effects of neighborhood disadvantage on white matter microstructure during adolescence, an important period of development that coincides with increased risk for psychopathology. Methods: In 200 adolescents (ages 13–20 years; 54.5% female, 4% nonbinary) recruited from 2 studies enriched for early adversity and depression, we examined whether neighborhood socioeconomic disadvantage derived from census tract data was related to white matter microstructure in several major white matter tracts. We also examined whether depressive symptoms and sex moderated these associations. Results: Greater neighborhood socioeconomic disadvantage was associated with lower fractional anisotropy (FA) in the left arcuate fasciculus (β = −0.24, false discovery rate [FDR]–corrected p = .035) and right uncinate fasciculus (β = −0.32, FDR-corrected p = .002) above and beyond the effects of family-level socioeconomic status. Depressive symptoms significantly moderated the association between left arcuate fasciculus FA and both neighborhood (β = 0.17, FDR-corrected p = .026) and unemployment (β = 0.22, FDR-corrected p = .004) disadvantage such that these associations were only significant in adolescents who reported less severe depression. Sex did not moderate the association between socioeconomic disadvantage and FA in these tracts. Conclusions: Greater neighborhood socioeconomic disadvantage, particularly poverty and educational attainment levels, was associated with lower FA in the arcuate fasciculus and uncinate fasciculus above and beyond the effects of family-level measures of socioeconomic status. These patterns were only observed in adolescents with low levels of depression, suggesting that we must be cautious about generalizing these findings to youths who struggle with mental health difficulties.http://www.sciencedirect.com/science/article/pii/S2667174323001404AdolescenceArcuate fasciculusPovertySocioeconomic statusUncinate fasciculus |
| spellingShingle | Artenisa Kulla Saché Coury Jordan M. Garcia Giana I. Teresi Lucinda M. Sisk Melissa Hansen Jonas G. Miller Ian H. Gotlib Tiffany C. Ho Neighborhood Socioeconomic Disadvantage and White Matter Microstructure of the Arcuate Fasciculus and Uncinate Fasciculus in Adolescents Biological Psychiatry Global Open Science Adolescence Arcuate fasciculus Poverty Socioeconomic status Uncinate fasciculus |
| title | Neighborhood Socioeconomic Disadvantage and White Matter Microstructure of the Arcuate Fasciculus and Uncinate Fasciculus in Adolescents |
| title_full | Neighborhood Socioeconomic Disadvantage and White Matter Microstructure of the Arcuate Fasciculus and Uncinate Fasciculus in Adolescents |
| title_fullStr | Neighborhood Socioeconomic Disadvantage and White Matter Microstructure of the Arcuate Fasciculus and Uncinate Fasciculus in Adolescents |
| title_full_unstemmed | Neighborhood Socioeconomic Disadvantage and White Matter Microstructure of the Arcuate Fasciculus and Uncinate Fasciculus in Adolescents |
| title_short | Neighborhood Socioeconomic Disadvantage and White Matter Microstructure of the Arcuate Fasciculus and Uncinate Fasciculus in Adolescents |
| title_sort | neighborhood socioeconomic disadvantage and white matter microstructure of the arcuate fasciculus and uncinate fasciculus in adolescents |
| topic | Adolescence Arcuate fasciculus Poverty Socioeconomic status Uncinate fasciculus |
| url | http://www.sciencedirect.com/science/article/pii/S2667174323001404 |
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