Use of a Longer Aglycon Moiety Bearing Sialyl α(2→3) Lactoside on the Glycopolymer for Lectin Evaluation
A polymerizable alcohol having 9 PEG repeats was prepared in order to mimic an oligosaccharide moiety. Sialyl α(2→3) lactose, which is known as a sugar moiety of GM3 ganglioside, was also prepared, and the polymerizable alcohol was condensed with the sialyl α(2→3) lactose derivative to afford the de...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/15/4/998 |
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| author | Ryota Adachi Takahiko Matsushita Tetsuo Koyama Ken Hatano Koji Matsuoka |
| author_facet | Ryota Adachi Takahiko Matsushita Tetsuo Koyama Ken Hatano Koji Matsuoka |
| author_sort | Ryota Adachi |
| collection | DOAJ |
| description | A polymerizable alcohol having 9 PEG repeats was prepared in order to mimic an oligosaccharide moiety. Sialyl α(2→3) lactose, which is known as a sugar moiety of GM3 ganglioside, was also prepared, and the polymerizable alcohol was condensed with the sialyl α(2→3) lactose derivative to afford the desired glycomonomer, which was further polymerized with or without acrylamide to give water-soluble glycopolymers. The glycopolymers had higher affinities than those of glycopolymers having sialyl lactose moieties with shorter aglycon moieties. |
| first_indexed | 2024-03-11T08:14:18Z |
| format | Article |
| id | doaj.art-ebe739cbfd1540e1b46b3a8c9c844ac0 |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-11T08:14:18Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-ebe739cbfd1540e1b46b3a8c9c844ac02023-11-16T22:52:46ZengMDPI AGPolymers2073-43602023-02-0115499810.3390/polym15040998Use of a Longer Aglycon Moiety Bearing Sialyl α(2→3) Lactoside on the Glycopolymer for Lectin EvaluationRyota Adachi0Takahiko Matsushita1Tetsuo Koyama2Ken Hatano3Koji Matsuoka4Area for Molecular Function, Division of Material Science, Graduate School of Science and Engineering, Saitama University, Sakura, Saitama 338-8570, JapanArea for Molecular Function, Division of Material Science, Graduate School of Science and Engineering, Saitama University, Sakura, Saitama 338-8570, JapanArea for Molecular Function, Division of Material Science, Graduate School of Science and Engineering, Saitama University, Sakura, Saitama 338-8570, JapanArea for Molecular Function, Division of Material Science, Graduate School of Science and Engineering, Saitama University, Sakura, Saitama 338-8570, JapanArea for Molecular Function, Division of Material Science, Graduate School of Science and Engineering, Saitama University, Sakura, Saitama 338-8570, JapanA polymerizable alcohol having 9 PEG repeats was prepared in order to mimic an oligosaccharide moiety. Sialyl α(2→3) lactose, which is known as a sugar moiety of GM3 ganglioside, was also prepared, and the polymerizable alcohol was condensed with the sialyl α(2→3) lactose derivative to afford the desired glycomonomer, which was further polymerized with or without acrylamide to give water-soluble glycopolymers. The glycopolymers had higher affinities than those of glycopolymers having sialyl lactose moieties with shorter aglycon moieties.https://www.mdpi.com/2073-4360/15/4/998glycopolymersradical polymerizationscarbohydratesglycosidesoligosaccharidesglycoclusters |
| spellingShingle | Ryota Adachi Takahiko Matsushita Tetsuo Koyama Ken Hatano Koji Matsuoka Use of a Longer Aglycon Moiety Bearing Sialyl α(2→3) Lactoside on the Glycopolymer for Lectin Evaluation Polymers glycopolymers radical polymerizations carbohydrates glycosides oligosaccharides glycoclusters |
| title | Use of a Longer Aglycon Moiety Bearing Sialyl α(2→3) Lactoside on the Glycopolymer for Lectin Evaluation |
| title_full | Use of a Longer Aglycon Moiety Bearing Sialyl α(2→3) Lactoside on the Glycopolymer for Lectin Evaluation |
| title_fullStr | Use of a Longer Aglycon Moiety Bearing Sialyl α(2→3) Lactoside on the Glycopolymer for Lectin Evaluation |
| title_full_unstemmed | Use of a Longer Aglycon Moiety Bearing Sialyl α(2→3) Lactoside on the Glycopolymer for Lectin Evaluation |
| title_short | Use of a Longer Aglycon Moiety Bearing Sialyl α(2→3) Lactoside on the Glycopolymer for Lectin Evaluation |
| title_sort | use of a longer aglycon moiety bearing sialyl α 2 3 lactoside on the glycopolymer for lectin evaluation |
| topic | glycopolymers radical polymerizations carbohydrates glycosides oligosaccharides glycoclusters |
| url | https://www.mdpi.com/2073-4360/15/4/998 |
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