Effective Antimicrobial Prophylaxis in Surgery: The Relevance and Role of Pharmacokinetics-Pharmacodynamics

Effective Antimicrobial Prophylaxis in Surgery: The Relevance and Role of Pharmacokinetics-Pharmacodynamics

Appropriate surgical antimicrobial prophylaxis (SAP) is an important measure in preventing surgical site infections (SSIs). Although antimicrobial pharmacokinetics–pharmacodynamics (PKPD) is integral to optimizing antibiotic dosing for the treatment of infections, there is less research on preventin...

Full description

Bibliographic Details
Main Author:	Sheryl A. Zelenitsky
Format:	Article
Language:	English
Published:	MDPI AG 2023-12-01
Series:	Antibiotics
Subjects:	antibiotic prophylaxis surgical prophylaxis cefazolin pharmacokinetics pharmacodynamics surgical site infection
Online Access:	https://www.mdpi.com/2079-6382/12/12/1738

Similar Items

Pharmacodynamic Evaluation of a Single Dose versus a 24-Hour Course of Multiple Doses of Cefazolin for Surgical Prophylaxis
by: Aaron Heffernan, et al.
Published: (2021-05-01)

Optimal timing of antimicrobial prophylaxis before surgery
by: Saarat Sathoo, et al.
Published: (2021-12-01)

Current Approaches to Surgical Antimicrobial Prophylaxis and Use of Antimicrobial Prophylaxis in Urological Procedures
by: Pınar Şen, et al.
Published: (2017-12-01)

Antimicrobial Prophylaxis in Surgery: A Cross Sectional Study
by: Rabin SABA, et al.
Published: (1999-12-01)

Six Long-Standing Questions about Antibiotic Prophylaxis in Surgery
by: Massimo Sartelli, et al.
Published: (2023-05-01)

Antibiotic Prophylaxis for Surgical Site Infection in General Surgery: Oncological Treatments and HIPEC
by: Carlo Vallicelli, et al.
Published: (2021-12-01)

Tailored Pre-Operative Antibiotic Prophylaxis to Prevent Post-Operative Surgical Site Infections in General Surgery
by: Mason Vierra, et al.
Published: (2024-01-01)

Antibiotic Prophylaxis for Ocular Surgical Infections
by: Ufuk Elgin
Published: (2011-10-01)

Antimicrobial prophylaxis uses and incidence of surgical site infection in Jayanagar General Hospital, Bangalore, India
by: Hassan Allaf Navirian, et al.
Published: (2022-01-01)

Protocol based Surgical Antimicrobial Prophylaxis in Endo-Urologic Surgeries: An Attempt to Convince the Surgeons to Follow the Guidelines
by: Manzoor Ahmad, et al.
Published: (2023-03-01)

Changing trends in antibiotic prophylaxis in head and neck surgery: Is short-term prophylaxis feasible?
by: Naresh K Panda, et al.
Published: (2016-01-01)

CEFAZOLIN PROPHYLACTIC EFFICACY ON PROSTHETIC JOINT INFECTION AFTER PRIMARY HIP ARTHROPLASTY
by: Shunsuke Kobayashi, et al.
Published: (2022-12-01)

Evaluation of Pediatric Surgical Site Infections Associated with Colorectal Surgeries at an Academic Children’s Hospital
by: Kimberly Pough, et al.
Published: (2020-04-01)

Appropriateness of choice and duration of surgical antibiotic prophylaxis and the incidence of surgical site infections: A prospective study
by: Abrar K. Thabit, PharmD, et al.
Published: (2023-02-01)

Antibiotic Prophylaxis for Hepato-Biliopancreatic Surgery—A Systematic Review
by: Francesca Steccanella, et al.
Published: (2022-02-01)

Compliance with Antibiotic Prophylaxis in Obstetric and Gynecological Surgeries in Two Peruvian Hospitals
by: Kovy Arteaga-Livias, et al.
Published: (2023-04-01)

Surgical antibiotic prophylaxis use and infection prevalence in non-cosmetic breast surgery procedures at a tertiary hospital in Western Australia—a retrospective study
by: Ainslie Lavers, et al.
Published: (2018-10-01)

Local Vancomycin Usage for Prophylaxis of Surgical Site Infections
by: Emre KARA, et al.
Published: (2020-03-01)

Implementing an Antimicrobial Stewardship Programme to Improve Adherence to a Perioperative Prophylaxis Guideline
by: Nehad J. Ahmed, et al.
Published: (2022-03-01)

Perioperative Antibiotic Prophylaxis in Pediatric Cardiac Surgery—Simple Is Better
by: Julia Burzyńska, et al.
Published: (2022-12-01)

A review of the practice of surgical antibiotic prophylaxis
by: Idemudia Otaigbe
Published: (2023-12-01)

The “Torment” of Surgical Antibiotic Prophylaxis among Surgeons
by: Massimo Sartelli, et al.
Published: (2021-11-01)

“A breach in the protocol for no good reason”: a surgical antimicrobial prophylaxis experience in an Ethiopian academic medical center
by: Veronica Afework, et al.
Published: (2023-07-01)

Impact of Antimicrobial Stewardship Interventions on Appropriateness of Surgical Antibiotic Prophylaxis: How to Improve
by: Beatrice Tiri, et al.
Published: (2020-04-01)

The Role of Antibiotic Prophylaxis in Anastomotic Leak Prevention during Elective Colorectal Surgery: Systematic Review and Meta-Analysis of Randomized Controlled Trials
by: Lidia Castagneto-Gissey, et al.
Published: (2023-02-01)

Surgical Antibiotic Prophylaxis: A Proposal for a Global Evidence-Based Bundle
by: Massimo Sartelli, et al.
Published: (2024-01-01)

Evaluation of the Adherence to the Antimicrobial Prophylaxis Guidelines before Cardiac Surgeries in a Specialized University Hospital: A Unicenter Cross-Sectional Study from Iran
by: Niloufar Sadat Mirasi, et al.
Published: (2023-12-01)

Impact of Antibiotic Prophylaxis on Surgical Site Infections in Cardiac Surgery
by: Christian de Tymowski, et al.
Published: (2023-01-01)

Effects of extended oral antibiotic prophylaxis on surgical site infections after instrumented spinal fusion: a cohort study of 901 patients with a minimum follow-up of 1 year
by: Miguel Menendez Garcia, et al.
Published: (2023-02-01)

Etiquette of the antibiotic decision-making process for surgical prophylaxis in Ethiopia: a triangulated ethnographic study
by: Getachew Alemkere, et al.
Published: (2023-12-01)

Comparison of Cefazolin/Metronidazole to Ampicillin/Sulbactam as Preoperative Antibiotics in Colorectal Surgery: A Retrospective, Single-Center Cohort Study
by: Jae Hyoung Im, et al.
Published: (2023-08-01)

Antimicrobial Prophylaxis Reduces the Rate of Surgical Site Infection in Upper Gastrointestinal Surgery: A Systematic Review
by: Luigi Marano, et al.
Published: (2022-02-01)

The effect of antibiotic prophylaxis on the incidence of surgical site infection after laparoscopic appendectomy for chronic appendicitis
by: Li Dai, et al.
Published: (2023-05-01)

Is the use of antibiotic prophylaxis in pediatric laparoscopic inguinal hernia repair necessary?
by: Ko Miyazaki, et al.
Published: (2023-04-01)

Association of antimicrobial perioperative prophylaxis with cefuroxime plus metronidazole or amoxicillin/clavulanic acid and surgical site infections in colorectal surgery
by: Elisavet Stavropoulou, et al.
Published: (2023-09-01)

ANTIBIOTIC PROPHYLAXIS FOR ABDOMINAL SURGERY: WHEN TO RECOMMEND? BRAZILIAN COLLEGE OF DIGESTIVE SURGERY POSITION PAPER
by: Alexandre Coutinho Teixeira de FREITAS, et al.
Published: (2023-09-01)

Variability in the serum and tissue concentrations of pre-incisional ceftriaxone for surgery in paediatric population and outcome of surgical-site infections; An open labelled, prospective, non-randomized, analytical study
by: Salim Sheikh, et al.
Published: (2022-01-01)

Analysis of the Validity of Perioperative Antibiotic Prophylaxis in Maxillofacial Surgery
by: Iwona Niedzielska, et al.
Published: (2022-09-01)

Antibiotic prophylaxis in foot and ankle surgery: a systematic review of the literature
by: Mr Ravi Krishān Modha, et al.
Published: (2018-11-01)

Effectiveness and Sustainability of an Antimicrobial Stewardship Program for Perioperative Prophylaxis in Pediatric Surgery
by: Daniele Donà, et al.
Published: (2020-06-01)