Glia and Neural Stem and Progenitor Cells of the Healthy and Ischemic Brain: The Workplace for the Wnt Signaling Pathway
Wnt signaling plays an important role in the self-renewal, fate-commitment and survival of the neural stem/progenitor cells (NS/PCs) of the adult central nervous system (CNS). Ischemic stroke impairs the proper functioning of the CNS and, therefore, active Wnt signaling may prevent, ameliorate, or e...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-07-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/11/7/804 |
| _version_ | 1797562296797495296 |
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| author | Tomas Knotek Lucie Janeckova Jan Kriska Vladimir Korinek Miroslava Anderova |
| author_facet | Tomas Knotek Lucie Janeckova Jan Kriska Vladimir Korinek Miroslava Anderova |
| author_sort | Tomas Knotek |
| collection | DOAJ |
| description | Wnt signaling plays an important role in the self-renewal, fate-commitment and survival of the neural stem/progenitor cells (NS/PCs) of the adult central nervous system (CNS). Ischemic stroke impairs the proper functioning of the CNS and, therefore, active Wnt signaling may prevent, ameliorate, or even reverse the negative effects of ischemic brain injury. In this review, we provide the current knowledge of Wnt signaling in the adult CNS, its status in diverse cell types, and the Wnt pathway’s impact on the properties of NS/PCs and glial cells in the context of ischemic injury. Finally, we summarize promising strategies that might be considered for stroke therapy, and we outline possible future directions of the field. |
| first_indexed | 2024-03-10T18:26:13Z |
| format | Article |
| id | doaj.art-ebe9433682a744b898cc61ce877d532d |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-10T18:26:13Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-ebe9433682a744b898cc61ce877d532d2023-11-20T07:01:07ZengMDPI AGGenes2073-44252020-07-0111780410.3390/genes11070804Glia and Neural Stem and Progenitor Cells of the Healthy and Ischemic Brain: The Workplace for the Wnt Signaling PathwayTomas Knotek0Lucie Janeckova1Jan Kriska2Vladimir Korinek3Miroslava Anderova4Institute of Experimental Medicine, Czech Academy of Sciences, 1083 Videnska, 142 20 Prague, Czech RepublicInstitute of Molecular Genetics, Czech Academy of Sciences, 1083 Videnska, 142 20 Prague, Czech RepublicInstitute of Experimental Medicine, Czech Academy of Sciences, 1083 Videnska, 142 20 Prague, Czech RepublicInstitute of Molecular Genetics, Czech Academy of Sciences, 1083 Videnska, 142 20 Prague, Czech RepublicInstitute of Experimental Medicine, Czech Academy of Sciences, 1083 Videnska, 142 20 Prague, Czech RepublicWnt signaling plays an important role in the self-renewal, fate-commitment and survival of the neural stem/progenitor cells (NS/PCs) of the adult central nervous system (CNS). Ischemic stroke impairs the proper functioning of the CNS and, therefore, active Wnt signaling may prevent, ameliorate, or even reverse the negative effects of ischemic brain injury. In this review, we provide the current knowledge of Wnt signaling in the adult CNS, its status in diverse cell types, and the Wnt pathway’s impact on the properties of NS/PCs and glial cells in the context of ischemic injury. Finally, we summarize promising strategies that might be considered for stroke therapy, and we outline possible future directions of the field.https://www.mdpi.com/2073-4425/11/7/804Wnt signalingcentral nervous systemneural stem/progenitor cellgliasubventricular zonesubgranular zone |
| spellingShingle | Tomas Knotek Lucie Janeckova Jan Kriska Vladimir Korinek Miroslava Anderova Glia and Neural Stem and Progenitor Cells of the Healthy and Ischemic Brain: The Workplace for the Wnt Signaling Pathway Genes Wnt signaling central nervous system neural stem/progenitor cell glia subventricular zone subgranular zone |
| title | Glia and Neural Stem and Progenitor Cells of the Healthy and Ischemic Brain: The Workplace for the Wnt Signaling Pathway |
| title_full | Glia and Neural Stem and Progenitor Cells of the Healthy and Ischemic Brain: The Workplace for the Wnt Signaling Pathway |
| title_fullStr | Glia and Neural Stem and Progenitor Cells of the Healthy and Ischemic Brain: The Workplace for the Wnt Signaling Pathway |
| title_full_unstemmed | Glia and Neural Stem and Progenitor Cells of the Healthy and Ischemic Brain: The Workplace for the Wnt Signaling Pathway |
| title_short | Glia and Neural Stem and Progenitor Cells of the Healthy and Ischemic Brain: The Workplace for the Wnt Signaling Pathway |
| title_sort | glia and neural stem and progenitor cells of the healthy and ischemic brain the workplace for the wnt signaling pathway |
| topic | Wnt signaling central nervous system neural stem/progenitor cell glia subventricular zone subgranular zone |
| url | https://www.mdpi.com/2073-4425/11/7/804 |
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