Retention of Neutralizing Response against SARS-CoV-2 Omicron Variant in Sputnik V-Vaccinated Individuals
The new Omicron variant of SARS-CoV-2, first identified in November 2021, is rapidly spreading all around the world. Omicron has become the dominant variant of SARS-CoV-2. There are many ongoing studies evaluating the effectiveness of existing vaccines. Studies on the neutralizing activity of vaccin...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/10/5/817 |
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| author | Daniele Lapa Daria M. Grousova Giulia Matusali Silvia Meschi Francesca Colavita Aurora Bettini Giulia Gramigna Massimo Francalancia Anna Rosa Garbuglia Enrico Girardi Vincenzo Puro Andrea Antinori Anna V. Kovyrshina Inna V. Dolzhikova Dmitry V. Shcheblyakov Amir I. Tukhvatulin Olga V. Zubkova Vladimir A. Gushchin Denis Y. Logunov Boris S. Naroditsky Francesco Vaia Alexander L. Gintsburg |
| author_facet | Daniele Lapa Daria M. Grousova Giulia Matusali Silvia Meschi Francesca Colavita Aurora Bettini Giulia Gramigna Massimo Francalancia Anna Rosa Garbuglia Enrico Girardi Vincenzo Puro Andrea Antinori Anna V. Kovyrshina Inna V. Dolzhikova Dmitry V. Shcheblyakov Amir I. Tukhvatulin Olga V. Zubkova Vladimir A. Gushchin Denis Y. Logunov Boris S. Naroditsky Francesco Vaia Alexander L. Gintsburg |
| author_sort | Daniele Lapa |
| collection | DOAJ |
| description | The new Omicron variant of SARS-CoV-2, first identified in November 2021, is rapidly spreading all around the world. Omicron has become the dominant variant of SARS-CoV-2. There are many ongoing studies evaluating the effectiveness of existing vaccines. Studies on the neutralizing activity of vaccinated sera against the Omicron variant are currently being carried out in many laboratories. In this study, we have shown the neutralizing activity of sera against the SARS-CoV-2 Omicron variant compared to the reference Wuhan D614G variant in individuals vaccinated with two doses of Sputnik V up to 6 months after vaccination and in individuals who experienced SARS-CoV-2 infection either before or after vaccination. As a control to our study we also measured neutralizing antibody titers in individuals vaccinated with two doses of BNT162b2. The decrease in NtAb titers to the Omicron variant was 8.1-fold for the group of Sputnik V-vaccinated individuals. When the samples were stratified for the time period after vaccination, a 7.6-fold or 8.8-fold decrease in NtAb titers was noticed after up to 3 and 3-to-6 months after vaccination. We observed a 6.7- and 5-fold decrease in Sputnik V-vaccinated individuals experiencing asymptomatic or symptomatic infection, respectively. These results highlight the observation that the decrease in NtAb to the SARS-CoV-2 Omicron variant compared to the Wuhan variant occurs for different COVID-19 vaccines in use, with some showing no neutralization at all, confirming the necessity of a third booster vaccination. |
| first_indexed | 2024-03-10T01:39:51Z |
| format | Article |
| id | doaj.art-ebea215a4c0d4c4698603fbd3fb5e45c |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-10T01:39:51Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-ebea215a4c0d4c4698603fbd3fb5e45c2023-11-23T13:27:46ZengMDPI AGVaccines2076-393X2022-05-0110581710.3390/vaccines10050817Retention of Neutralizing Response against SARS-CoV-2 Omicron Variant in Sputnik V-Vaccinated IndividualsDaniele Lapa0Daria M. Grousova1Giulia Matusali2Silvia Meschi3Francesca Colavita4Aurora Bettini5Giulia Gramigna6Massimo Francalancia7Anna Rosa Garbuglia8Enrico Girardi9Vincenzo Puro10Andrea Antinori11Anna V. Kovyrshina12Inna V. Dolzhikova13Dmitry V. Shcheblyakov14Amir I. Tukhvatulin15Olga V. Zubkova16Vladimir A. Gushchin17Denis Y. Logunov18Boris S. Naroditsky19Francesco Vaia20Alexander L. Gintsburg21INMI “National Institute of Infectious Diseases” Lazzaro Spallanzani, IRCCS, 00149 Rome, ItalyFSBI “National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya” of the Ministry of Health of the Russian Federation, 123098 Moscow, RussiaINMI “National Institute of Infectious Diseases” Lazzaro Spallanzani, IRCCS, 00149 Rome, ItalyINMI “National Institute of Infectious Diseases” Lazzaro Spallanzani, IRCCS, 00149 Rome, ItalyINMI “National Institute of Infectious Diseases” Lazzaro Spallanzani, IRCCS, 00149 Rome, ItalyINMI “National Institute of Infectious Diseases” Lazzaro Spallanzani, IRCCS, 00149 Rome, ItalyINMI “National Institute of Infectious Diseases” Lazzaro Spallanzani, IRCCS, 00149 Rome, ItalyINMI “National Institute of Infectious Diseases” Lazzaro Spallanzani, IRCCS, 00149 Rome, ItalyINMI “National Institute of Infectious Diseases” Lazzaro Spallanzani, IRCCS, 00149 Rome, ItalyINMI “National Institute of Infectious Diseases” Lazzaro Spallanzani, IRCCS, 00149 Rome, ItalyINMI “National Institute of Infectious Diseases” Lazzaro Spallanzani, IRCCS, 00149 Rome, ItalyINMI “National Institute of Infectious Diseases” Lazzaro Spallanzani, IRCCS, 00149 Rome, ItalyFSBI “National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya” of the Ministry of Health of the Russian Federation, 123098 Moscow, RussiaFSBI “National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya” of the Ministry of Health of the Russian Federation, 123098 Moscow, RussiaFSBI “National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya” of the Ministry of Health of the Russian Federation, 123098 Moscow, RussiaFSBI “National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya” of the Ministry of Health of the Russian Federation, 123098 Moscow, RussiaFSBI “National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya” of the Ministry of Health of the Russian Federation, 123098 Moscow, RussiaFSBI “National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya” of the Ministry of Health of the Russian Federation, 123098 Moscow, RussiaFSBI “National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya” of the Ministry of Health of the Russian Federation, 123098 Moscow, RussiaFSBI “National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya” of the Ministry of Health of the Russian Federation, 123098 Moscow, RussiaINMI “National Institute of Infectious Diseases” Lazzaro Spallanzani, IRCCS, 00149 Rome, ItalyFSBI “National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya” of the Ministry of Health of the Russian Federation, 123098 Moscow, RussiaThe new Omicron variant of SARS-CoV-2, first identified in November 2021, is rapidly spreading all around the world. Omicron has become the dominant variant of SARS-CoV-2. There are many ongoing studies evaluating the effectiveness of existing vaccines. Studies on the neutralizing activity of vaccinated sera against the Omicron variant are currently being carried out in many laboratories. In this study, we have shown the neutralizing activity of sera against the SARS-CoV-2 Omicron variant compared to the reference Wuhan D614G variant in individuals vaccinated with two doses of Sputnik V up to 6 months after vaccination and in individuals who experienced SARS-CoV-2 infection either before or after vaccination. As a control to our study we also measured neutralizing antibody titers in individuals vaccinated with two doses of BNT162b2. The decrease in NtAb titers to the Omicron variant was 8.1-fold for the group of Sputnik V-vaccinated individuals. When the samples were stratified for the time period after vaccination, a 7.6-fold or 8.8-fold decrease in NtAb titers was noticed after up to 3 and 3-to-6 months after vaccination. We observed a 6.7- and 5-fold decrease in Sputnik V-vaccinated individuals experiencing asymptomatic or symptomatic infection, respectively. These results highlight the observation that the decrease in NtAb to the SARS-CoV-2 Omicron variant compared to the Wuhan variant occurs for different COVID-19 vaccines in use, with some showing no neutralization at all, confirming the necessity of a third booster vaccination.https://www.mdpi.com/2076-393X/10/5/817SARS-CoV-2vaccineantibody responseOmicronneutralization |
| spellingShingle | Daniele Lapa Daria M. Grousova Giulia Matusali Silvia Meschi Francesca Colavita Aurora Bettini Giulia Gramigna Massimo Francalancia Anna Rosa Garbuglia Enrico Girardi Vincenzo Puro Andrea Antinori Anna V. Kovyrshina Inna V. Dolzhikova Dmitry V. Shcheblyakov Amir I. Tukhvatulin Olga V. Zubkova Vladimir A. Gushchin Denis Y. Logunov Boris S. Naroditsky Francesco Vaia Alexander L. Gintsburg Retention of Neutralizing Response against SARS-CoV-2 Omicron Variant in Sputnik V-Vaccinated Individuals Vaccines SARS-CoV-2 vaccine antibody response Omicron neutralization |
| title | Retention of Neutralizing Response against SARS-CoV-2 Omicron Variant in Sputnik V-Vaccinated Individuals |
| title_full | Retention of Neutralizing Response against SARS-CoV-2 Omicron Variant in Sputnik V-Vaccinated Individuals |
| title_fullStr | Retention of Neutralizing Response against SARS-CoV-2 Omicron Variant in Sputnik V-Vaccinated Individuals |
| title_full_unstemmed | Retention of Neutralizing Response against SARS-CoV-2 Omicron Variant in Sputnik V-Vaccinated Individuals |
| title_short | Retention of Neutralizing Response against SARS-CoV-2 Omicron Variant in Sputnik V-Vaccinated Individuals |
| title_sort | retention of neutralizing response against sars cov 2 omicron variant in sputnik v vaccinated individuals |
| topic | SARS-CoV-2 vaccine antibody response Omicron neutralization |
| url | https://www.mdpi.com/2076-393X/10/5/817 |
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