Hospitalised patients with suspected 2009 H1N1 Influenza A in a hospital in Norway, July - December 2009
<p>Abstract</p> <p>Background</p> <p>The main objective of this study was to describe the patients who were hospitalised at Oslo University Hospital Aker during the first wave of pandemic Influenza A (H1N1) in Norway.</p> <p>Methods</p> <p>Clinic...
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| Format: | Article |
| Language: | English |
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BMC
2011-03-01
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| Series: | BMC Infectious Diseases |
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| Online Access: | http://www.biomedcentral.com/1471-2334/11/75 |
| _version_ | 1818827236225056768 |
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| author | Kran Anne-Marte B Kjekshus Harald Berild Dag Pillgram Magnus Brandsaeter Bjorn J Bergersen Bente M |
| author_facet | Kran Anne-Marte B Kjekshus Harald Berild Dag Pillgram Magnus Brandsaeter Bjorn J Bergersen Bente M |
| author_sort | Kran Anne-Marte B |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>The main objective of this study was to describe the patients who were hospitalised at Oslo University Hospital Aker during the first wave of pandemic Influenza A (H1N1) in Norway.</p> <p>Methods</p> <p>Clinical data on all patients hospitalised with influenza-like illness from July to the end of November 2009 were collected prospectively. Patients with confirmed H1N1 Influenza A were compared to patients with negative H1N1 tests.</p> <p>Results</p> <p>182 patients were hospitalised with suspected H1N1 Influenza A and 64 (35%) tested positive. Seventeen patients with positive tests (27%) were admitted to an intensive care unit and four patients died (6%). The H1N1 positive patients were younger, consisted of a higher proportion of non-ethnic Norwegians, had a higher heart rate on admission, and fewer had pre-existing hypertension, compared to the H1N1 negative patients. However, hypertension was the only medical condition that was significantly associated with a more serious outcome defined as ICU admission or death, with a univariate odds ratio of the composite endpoint in H1N1 positive and negative patients of 6.1 (95% CI 1.3-29.3) and 3.2 (95% CI 1.2-8.7), respectively. Chest radiography revealed pneumonia in 24/59 H1N1 positive patients. 63 of 64 H1N1 positive patients received oseltamivir.</p> <p>Conclusions</p> <p>The extra burden of hospitalisations was relatively small and we managed to admit all the patients with suspected H1N1 influenza without opening new pandemic isolation wards. The morbidity and mortality were similar to reports from comparable countries. Established hypertension was associated with more severe morbidity and patients with hypertension should be considered candidates for vaccination programs in future pandemics.</p> |
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| format | Article |
| id | doaj.art-ebea4e8602de4695bc31952c1e1971b3 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-19T00:40:21Z |
| publishDate | 2011-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-ebea4e8602de4695bc31952c1e1971b32022-12-21T20:44:36ZengBMCBMC Infectious Diseases1471-23342011-03-011117510.1186/1471-2334-11-75Hospitalised patients with suspected 2009 H1N1 Influenza A in a hospital in Norway, July - December 2009Kran Anne-Marte BKjekshus HaraldBerild DagPillgram MagnusBrandsaeter Bjorn JBergersen Bente M<p>Abstract</p> <p>Background</p> <p>The main objective of this study was to describe the patients who were hospitalised at Oslo University Hospital Aker during the first wave of pandemic Influenza A (H1N1) in Norway.</p> <p>Methods</p> <p>Clinical data on all patients hospitalised with influenza-like illness from July to the end of November 2009 were collected prospectively. Patients with confirmed H1N1 Influenza A were compared to patients with negative H1N1 tests.</p> <p>Results</p> <p>182 patients were hospitalised with suspected H1N1 Influenza A and 64 (35%) tested positive. Seventeen patients with positive tests (27%) were admitted to an intensive care unit and four patients died (6%). The H1N1 positive patients were younger, consisted of a higher proportion of non-ethnic Norwegians, had a higher heart rate on admission, and fewer had pre-existing hypertension, compared to the H1N1 negative patients. However, hypertension was the only medical condition that was significantly associated with a more serious outcome defined as ICU admission or death, with a univariate odds ratio of the composite endpoint in H1N1 positive and negative patients of 6.1 (95% CI 1.3-29.3) and 3.2 (95% CI 1.2-8.7), respectively. Chest radiography revealed pneumonia in 24/59 H1N1 positive patients. 63 of 64 H1N1 positive patients received oseltamivir.</p> <p>Conclusions</p> <p>The extra burden of hospitalisations was relatively small and we managed to admit all the patients with suspected H1N1 influenza without opening new pandemic isolation wards. The morbidity and mortality were similar to reports from comparable countries. Established hypertension was associated with more severe morbidity and patients with hypertension should be considered candidates for vaccination programs in future pandemics.</p>http://www.biomedcentral.com/1471-2334/11/75Influenza A H1N1pandemichypertensionisolationoutcome |
| spellingShingle | Kran Anne-Marte B Kjekshus Harald Berild Dag Pillgram Magnus Brandsaeter Bjorn J Bergersen Bente M Hospitalised patients with suspected 2009 H1N1 Influenza A in a hospital in Norway, July - December 2009 BMC Infectious Diseases Influenza A H1N1 pandemic hypertension isolation outcome |
| title | Hospitalised patients with suspected 2009 H1N1 Influenza A in a hospital in Norway, July - December 2009 |
| title_full | Hospitalised patients with suspected 2009 H1N1 Influenza A in a hospital in Norway, July - December 2009 |
| title_fullStr | Hospitalised patients with suspected 2009 H1N1 Influenza A in a hospital in Norway, July - December 2009 |
| title_full_unstemmed | Hospitalised patients with suspected 2009 H1N1 Influenza A in a hospital in Norway, July - December 2009 |
| title_short | Hospitalised patients with suspected 2009 H1N1 Influenza A in a hospital in Norway, July - December 2009 |
| title_sort | hospitalised patients with suspected 2009 h1n1 influenza a in a hospital in norway july december 2009 |
| topic | Influenza A H1N1 pandemic hypertension isolation outcome |
| url | http://www.biomedcentral.com/1471-2334/11/75 |
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