The role of alternative pre-mRNA splicing in cancer progression
Abstract Alternative pre-mRNA splicing is a critical mechanism that generates multiple mRNA from a single gene, thereby increasing the diversity of the proteome. Recent research has highlighted the significance of specific splicing isoforms in cellular processes, particularly in regulating cell numb...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-10-01
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| Series: | Cancer Cell International |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12935-023-03094-3 |
| _version_ | 1827708203980292096 |
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| author | Sunkyung Choi Namjoon Cho Eun-Mi Kim Kee K. Kim |
| author_facet | Sunkyung Choi Namjoon Cho Eun-Mi Kim Kee K. Kim |
| author_sort | Sunkyung Choi |
| collection | DOAJ |
| description | Abstract Alternative pre-mRNA splicing is a critical mechanism that generates multiple mRNA from a single gene, thereby increasing the diversity of the proteome. Recent research has highlighted the significance of specific splicing isoforms in cellular processes, particularly in regulating cell numbers. In this review, we examine the current understanding of the role of alternative splicing in controlling cancer cell growth and discuss specific splicing factors and isoforms and their molecular mechanisms in cancer progression. These isoforms have been found to intricately control signaling pathways crucial for cell cycle progression, proliferation, and apoptosis. Furthermore, studies have elucidated the characteristics and functional importance of splicing factors that influence cell numbers. Abnormal expression of oncogenic splicing isoforms and splicing factors, as well as disruptions in splicing caused by genetic mutations, have been implicated in the development and progression of tumors. Collectively, these findings provide valuable insights into the complex interplay between alternative splicing and cell proliferation, thereby suggesting the potential of alternative splicing as a therapeutic target for cancer. |
| first_indexed | 2024-03-10T17:00:23Z |
| format | Article |
| id | doaj.art-ebea55f7fa264153b61100dcb361e76f |
| institution | Directory Open Access Journal |
| issn | 1475-2867 |
| language | English |
| last_indexed | 2024-03-10T17:00:23Z |
| publishDate | 2023-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer Cell International |
| spelling | doaj.art-ebea55f7fa264153b61100dcb361e76f2023-11-20T10:59:23ZengBMCCancer Cell International1475-28672023-10-0123111810.1186/s12935-023-03094-3The role of alternative pre-mRNA splicing in cancer progressionSunkyung Choi0Namjoon Cho1Eun-Mi Kim2Kee K. Kim3Department of Biochemistry, College of Natural Sciences, Chungnam National UniversityDepartment of Biochemistry, College of Natural Sciences, Chungnam National UniversityDepartment of Predictive Toxicology, Korea Institute of ToxicologyDepartment of Biochemistry, College of Natural Sciences, Chungnam National UniversityAbstract Alternative pre-mRNA splicing is a critical mechanism that generates multiple mRNA from a single gene, thereby increasing the diversity of the proteome. Recent research has highlighted the significance of specific splicing isoforms in cellular processes, particularly in regulating cell numbers. In this review, we examine the current understanding of the role of alternative splicing in controlling cancer cell growth and discuss specific splicing factors and isoforms and their molecular mechanisms in cancer progression. These isoforms have been found to intricately control signaling pathways crucial for cell cycle progression, proliferation, and apoptosis. Furthermore, studies have elucidated the characteristics and functional importance of splicing factors that influence cell numbers. Abnormal expression of oncogenic splicing isoforms and splicing factors, as well as disruptions in splicing caused by genetic mutations, have been implicated in the development and progression of tumors. Collectively, these findings provide valuable insights into the complex interplay between alternative splicing and cell proliferation, thereby suggesting the potential of alternative splicing as a therapeutic target for cancer.https://doi.org/10.1186/s12935-023-03094-3Alternative pre-mRNA splicingCancerCell proliferationSignaling pathwaySplicing factor |
| spellingShingle | Sunkyung Choi Namjoon Cho Eun-Mi Kim Kee K. Kim The role of alternative pre-mRNA splicing in cancer progression Cancer Cell International Alternative pre-mRNA splicing Cancer Cell proliferation Signaling pathway Splicing factor |
| title | The role of alternative pre-mRNA splicing in cancer progression |
| title_full | The role of alternative pre-mRNA splicing in cancer progression |
| title_fullStr | The role of alternative pre-mRNA splicing in cancer progression |
| title_full_unstemmed | The role of alternative pre-mRNA splicing in cancer progression |
| title_short | The role of alternative pre-mRNA splicing in cancer progression |
| title_sort | role of alternative pre mrna splicing in cancer progression |
| topic | Alternative pre-mRNA splicing Cancer Cell proliferation Signaling pathway Splicing factor |
| url | https://doi.org/10.1186/s12935-023-03094-3 |
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