The coronavirus disease 2019 infection in pregnancy and adverse pregnancy outcomes: a systematic review and meta-analysis
The coronavirus disease 2019 (COVID-19) outbreak which started in December 2019 rapidly developed into a global health concern. Pregnant women are susceptible to respiratory infections and can experience adverse outcomes. This systematic review and meta-analysis compared pregnancy outcomes according...
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| Format: | Article |
| Language: | English |
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Korean Society of Obstetrics and Gynecology
2023-07-01
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| Series: | Obstetrics & Gynecology Science |
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| Online Access: | http://www.ogscience.org/upload/pdf/ogs-22323.pdf |
| _version_ | 1827898510533459968 |
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| author | Yeonsong Jeong Min-A Kim |
| author_facet | Yeonsong Jeong Min-A Kim |
| author_sort | Yeonsong Jeong |
| collection | DOAJ |
| description | The coronavirus disease 2019 (COVID-19) outbreak which started in December 2019 rapidly developed into a global health concern. Pregnant women are susceptible to respiratory infections and can experience adverse outcomes. This systematic review and meta-analysis compared pregnancy outcomes according to COVID-19 disease status. The MEDLINE, EMBASE, and Cochrane Library databases were searched for relevant articles published between December 1, 2019, and October 19, 2022. Main inclusion criterion was any population-based, cross-sectional, cohort, or case-control study that assessed pregnancy outcomes in women with or without laboratory-confirmed COVID-19. Sixty-nine studies including 1,606,543 pregnant women (39,716 [2.4%] diagnosed with COVID-19) were retrieved. COVID-19-infected pregnant women had a higher risk of preterm birth (odds ratio [OR], 1.59; 95% confidence interval [CI], 1.42–1.78), preeclampsia (OR, 1.41; 95% CI, 1.30–1.53), low birth weight (OR, 1.52; 95% CI, 1.30–1.79), cesarean delivery (OR, 1.20; 95% CI, 1.10–1.30), stillbirth (OR, 1.71; 95% CI, 1.39–2.10), fetal distress (OR, 2.49; 95% CI, 1.54–4.03), neonatal intensive care unit admission (OR, 2.33; 95% CI, 1.72–3.16), perinatal mortality (OR, 1.96; 95% CI, 1.15–3.34), and maternal mortality (OR, 6.15; 95% CI, 3.74–10.10). There were no significant differences in total miscarriage, preterm premature rupture of membranes, postpartum hemorrhage, cholestasis, or chorioamnionitis according to infection. This review demonstrates that COVID-19 infection during pregnancy can lead to adverse pregnancy outcomes. This information could aid researchers and clinicians in preparing for another pandemic caused by newly discovered respiratory viruses. The findings of this study may assist with evidence-based counseling and help clinicians manage pregnant women with COVID-19. |
| first_indexed | 2024-03-12T23:04:12Z |
| format | Article |
| id | doaj.art-ebea828bbce54ad2a57b9337dda9de10 |
| institution | Directory Open Access Journal |
| issn | 2287-8572 2287-8580 |
| language | English |
| last_indexed | 2024-03-12T23:04:12Z |
| publishDate | 2023-07-01 |
| publisher | Korean Society of Obstetrics and Gynecology |
| record_format | Article |
| series | Obstetrics & Gynecology Science |
| spelling | doaj.art-ebea828bbce54ad2a57b9337dda9de102023-07-19T07:09:15ZengKorean Society of Obstetrics and GynecologyObstetrics & Gynecology Science2287-85722287-85802023-07-0166427028910.5468/ogs.223238754The coronavirus disease 2019 infection in pregnancy and adverse pregnancy outcomes: a systematic review and meta-analysisYeonsong JeongMin-A KimThe coronavirus disease 2019 (COVID-19) outbreak which started in December 2019 rapidly developed into a global health concern. Pregnant women are susceptible to respiratory infections and can experience adverse outcomes. This systematic review and meta-analysis compared pregnancy outcomes according to COVID-19 disease status. The MEDLINE, EMBASE, and Cochrane Library databases were searched for relevant articles published between December 1, 2019, and October 19, 2022. Main inclusion criterion was any population-based, cross-sectional, cohort, or case-control study that assessed pregnancy outcomes in women with or without laboratory-confirmed COVID-19. Sixty-nine studies including 1,606,543 pregnant women (39,716 [2.4%] diagnosed with COVID-19) were retrieved. COVID-19-infected pregnant women had a higher risk of preterm birth (odds ratio [OR], 1.59; 95% confidence interval [CI], 1.42–1.78), preeclampsia (OR, 1.41; 95% CI, 1.30–1.53), low birth weight (OR, 1.52; 95% CI, 1.30–1.79), cesarean delivery (OR, 1.20; 95% CI, 1.10–1.30), stillbirth (OR, 1.71; 95% CI, 1.39–2.10), fetal distress (OR, 2.49; 95% CI, 1.54–4.03), neonatal intensive care unit admission (OR, 2.33; 95% CI, 1.72–3.16), perinatal mortality (OR, 1.96; 95% CI, 1.15–3.34), and maternal mortality (OR, 6.15; 95% CI, 3.74–10.10). There were no significant differences in total miscarriage, preterm premature rupture of membranes, postpartum hemorrhage, cholestasis, or chorioamnionitis according to infection. This review demonstrates that COVID-19 infection during pregnancy can lead to adverse pregnancy outcomes. This information could aid researchers and clinicians in preparing for another pandemic caused by newly discovered respiratory viruses. The findings of this study may assist with evidence-based counseling and help clinicians manage pregnant women with COVID-19.http://www.ogscience.org/upload/pdf/ogs-22323.pdfcoronavirus disease 2019pregnancy outcomespregnancy complicationsrespiratory tract infectionsviral infection |
| spellingShingle | Yeonsong Jeong Min-A Kim The coronavirus disease 2019 infection in pregnancy and adverse pregnancy outcomes: a systematic review and meta-analysis Obstetrics & Gynecology Science coronavirus disease 2019 pregnancy outcomes pregnancy complications respiratory tract infections viral infection |
| title | The coronavirus disease 2019 infection in pregnancy and adverse pregnancy outcomes: a systematic review and meta-analysis |
| title_full | The coronavirus disease 2019 infection in pregnancy and adverse pregnancy outcomes: a systematic review and meta-analysis |
| title_fullStr | The coronavirus disease 2019 infection in pregnancy and adverse pregnancy outcomes: a systematic review and meta-analysis |
| title_full_unstemmed | The coronavirus disease 2019 infection in pregnancy and adverse pregnancy outcomes: a systematic review and meta-analysis |
| title_short | The coronavirus disease 2019 infection in pregnancy and adverse pregnancy outcomes: a systematic review and meta-analysis |
| title_sort | coronavirus disease 2019 infection in pregnancy and adverse pregnancy outcomes a systematic review and meta analysis |
| topic | coronavirus disease 2019 pregnancy outcomes pregnancy complications respiratory tract infections viral infection |
| url | http://www.ogscience.org/upload/pdf/ogs-22323.pdf |
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