Interaction between NBS1 and the mTOR/Rictor/SIN1 complex through specific domains.

Interaction between NBS1 and the mTOR/Rictor/SIN1 complex through specific domains.

Nijmegen breakage syndrome (NBS) is a chromosomal-instability syndrome. The NBS gene product, NBS1 (p95 or nibrin), is a part of the Mre11-Rad50-NBS1 complex. SIN1 is a component of the mTOR/Rictor/SIN1 complex mediating the activation of Akt. Here we show that NBS1 interacted with mTOR, Rictor, and...

Full description

Bibliographic Details
Main Authors: Jian-Qiu Wang, Jian-Hong Chen, Yen-Chung Chen, Mei-Yu Chen, Chia-Ying Hsieh, Shu-Chun Teng, Kou-Juey Wu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3675082?pdf=render

Similar Items

Similar Items