Anticoronavirus Evaluation of Antimicrobial Diterpenoids: Application of New Ferruginol Analogues
The abietane diterpene (+)-ferruginol (<b>1</b>), like other natural and semisynthetic abietanes, is distinguished for its interesting pharmacological properties such as antimicrobial activity, including antiviral. In this study, selected C18-functionalized semisynthetic abietanes prepar...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/15/6/1342 |
| _version_ | 1797592403849248768 |
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| author | Mihayl Varbanov Stéphanie Philippot Miguel A. González-Cardenete |
| author_facet | Mihayl Varbanov Stéphanie Philippot Miguel A. González-Cardenete |
| author_sort | Mihayl Varbanov |
| collection | DOAJ |
| description | The abietane diterpene (+)-ferruginol (<b>1</b>), like other natural and semisynthetic abietanes, is distinguished for its interesting pharmacological properties such as antimicrobial activity, including antiviral. In this study, selected C18-functionalized semisynthetic abietanes prepared from the commercially available (+)-dehydroabietylamine or methyl dehydroabietate were tested in vitro against human coronavirus 229E (HCoV-229E). As a result, a new ferruginol analogue caused a relevant reduction in virus titer as well as the inhibition of a cytopathic effect. A toxicity prediction based on in silico analysis was also performed as well as an estimation of bioavailability. This work demonstrates the antimicrobial and specifically antiviral activity of two tested compounds, making these molecules interesting for the development of new antivirals. |
| first_indexed | 2024-03-11T01:50:33Z |
| format | Article |
| id | doaj.art-ebebb60a7b6a404cb606574bd8c7b201 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-11T01:50:33Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-ebebb60a7b6a404cb606574bd8c7b2012023-11-18T13:02:28ZengMDPI AGViruses1999-49152023-06-01156134210.3390/v15061342Anticoronavirus Evaluation of Antimicrobial Diterpenoids: Application of New Ferruginol AnaloguesMihayl Varbanov0Stéphanie Philippot1Miguel A. González-Cardenete2Université de Lorraine, CNRS, L2CM, F-54000 Nancy, FranceUniversité de Lorraine, CNRS, L2CM, F-54000 Nancy, FranceInstituto de Tecnologia Química (UPV-CSIC), Universitat Politècnica de Valencia-Consejo Superior de Investigaciones Científicas, Avenida de los Naranjos s/n, 46022 Valencia, SpainThe abietane diterpene (+)-ferruginol (<b>1</b>), like other natural and semisynthetic abietanes, is distinguished for its interesting pharmacological properties such as antimicrobial activity, including antiviral. In this study, selected C18-functionalized semisynthetic abietanes prepared from the commercially available (+)-dehydroabietylamine or methyl dehydroabietate were tested in vitro against human coronavirus 229E (HCoV-229E). As a result, a new ferruginol analogue caused a relevant reduction in virus titer as well as the inhibition of a cytopathic effect. A toxicity prediction based on in silico analysis was also performed as well as an estimation of bioavailability. This work demonstrates the antimicrobial and specifically antiviral activity of two tested compounds, making these molecules interesting for the development of new antivirals.https://www.mdpi.com/1999-4915/15/6/1342antimicrobialcoronavirusabietanedehydroabietylaminephenolphthalimide |
| spellingShingle | Mihayl Varbanov Stéphanie Philippot Miguel A. González-Cardenete Anticoronavirus Evaluation of Antimicrobial Diterpenoids: Application of New Ferruginol Analogues Viruses antimicrobial coronavirus abietane dehydroabietylamine phenol phthalimide |
| title | Anticoronavirus Evaluation of Antimicrobial Diterpenoids: Application of New Ferruginol Analogues |
| title_full | Anticoronavirus Evaluation of Antimicrobial Diterpenoids: Application of New Ferruginol Analogues |
| title_fullStr | Anticoronavirus Evaluation of Antimicrobial Diterpenoids: Application of New Ferruginol Analogues |
| title_full_unstemmed | Anticoronavirus Evaluation of Antimicrobial Diterpenoids: Application of New Ferruginol Analogues |
| title_short | Anticoronavirus Evaluation of Antimicrobial Diterpenoids: Application of New Ferruginol Analogues |
| title_sort | anticoronavirus evaluation of antimicrobial diterpenoids application of new ferruginol analogues |
| topic | antimicrobial coronavirus abietane dehydroabietylamine phenol phthalimide |
| url | https://www.mdpi.com/1999-4915/15/6/1342 |
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