The predictive efficacy of tumor mutation burden in immunotherapy across multiple cancer types: A meta-analysis and bioinformatics analysis

The predictive efficacy of tumor mutation burden in immunotherapy across multiple cancer types: A meta-analysis and bioinformatics analysis

Purpose: To explore the predictive efficacy of tumor mutation burden (TMB) as a potential biomarker for cancer patients treated with Immune checkpoint inhibitors (ICIs). Methods: We systematically searched PubMed, Cochrane Library, Embase and Web of Science for clinical studies (published between Ja...

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Bibliographic Details
Main Authors: Jinlong Cao, Xin Yang, Siyu Chen, Jirong Wang, Xinpeng Fan, Shengjun Fu, Li Yang
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Translational Oncology
Subjects:
Tumor mutation burden
Immunotherapy
Immune checkpoint inhibitors
Meta-analysis
Bioinformatics
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523322000377

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