Simultaneous electrochemical determination of morphine and methadone by using CMK-5 mesoporous carbon and multivariate calibration
Abstract For the first time, a sensitive electrochemical sensor using a glassy carbon electrode modified with CMK-5 Ordered mesoporous carbon was fabricated for simultaneous analysis of morphine and methadone. Modern electrochemical FFT-SWV techniques and partial least-squares as a multivariable ana...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-05-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-12506-9 |
| _version_ | 1811341313485832192 |
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| author | Mohammad Mehdi Habibi Jahan B. Ghasemi Alireza Badiei Parviz Norouzi |
| author_facet | Mohammad Mehdi Habibi Jahan B. Ghasemi Alireza Badiei Parviz Norouzi |
| author_sort | Mohammad Mehdi Habibi |
| collection | DOAJ |
| description | Abstract For the first time, a sensitive electrochemical sensor using a glassy carbon electrode modified with CMK-5 Ordered mesoporous carbon was fabricated for simultaneous analysis of morphine and methadone. Modern electrochemical FFT-SWV techniques and partial least-squares as a multivariable analysis were used in this method. CMK-5 nanostructures were characterized by field emission scanning electron microscopy, transmission electron microscopy, X-ray diffraction analysis, and Raman spectroscopy. Variables such as accumulation time and pH for the proposed sensor were optimized before quantitative analysis. To train the proposed sensor, standard mixtures of morphine (MOR), and methadone (MET) were prepared in the established linear ranges of the analyzes. The results obtained from training samples were used for PLS modeling. The efficiency of the model was determined using test and real matrix samples. The root mean square error of prediction and the squared correlation coefficients (R2 p) for MET and MOR were estimated to be 0.00772 and 0.00892 and 0.948 to 0.990, respectively. The recoveries in urine samples were reported to be 97.0 and 105.6% for both MOR and MET, respectively. |
| first_indexed | 2024-04-13T18:55:01Z |
| format | Article |
| id | doaj.art-ebecdd88e95e47a790d2f7cee8e7f30c |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-13T18:55:01Z |
| publishDate | 2022-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-ebecdd88e95e47a790d2f7cee8e7f30c2022-12-22T02:34:18ZengNature PortfolioScientific Reports2045-23222022-05-0112111310.1038/s41598-022-12506-9Simultaneous electrochemical determination of morphine and methadone by using CMK-5 mesoporous carbon and multivariate calibrationMohammad Mehdi Habibi0Jahan B. Ghasemi1Alireza Badiei2Parviz Norouzi3School of Chemistry, College of Science, University of TehranSchool of Chemistry, College of Science, University of TehranSchool of Chemistry, College of Science, University of TehranCenter of Excellence in Electrochemistry, Department of Chemistry, University of TehranAbstract For the first time, a sensitive electrochemical sensor using a glassy carbon electrode modified with CMK-5 Ordered mesoporous carbon was fabricated for simultaneous analysis of morphine and methadone. Modern electrochemical FFT-SWV techniques and partial least-squares as a multivariable analysis were used in this method. CMK-5 nanostructures were characterized by field emission scanning electron microscopy, transmission electron microscopy, X-ray diffraction analysis, and Raman spectroscopy. Variables such as accumulation time and pH for the proposed sensor were optimized before quantitative analysis. To train the proposed sensor, standard mixtures of morphine (MOR), and methadone (MET) were prepared in the established linear ranges of the analyzes. The results obtained from training samples were used for PLS modeling. The efficiency of the model was determined using test and real matrix samples. The root mean square error of prediction and the squared correlation coefficients (R2 p) for MET and MOR were estimated to be 0.00772 and 0.00892 and 0.948 to 0.990, respectively. The recoveries in urine samples were reported to be 97.0 and 105.6% for both MOR and MET, respectively.https://doi.org/10.1038/s41598-022-12506-9 |
| spellingShingle | Mohammad Mehdi Habibi Jahan B. Ghasemi Alireza Badiei Parviz Norouzi Simultaneous electrochemical determination of morphine and methadone by using CMK-5 mesoporous carbon and multivariate calibration Scientific Reports |
| title | Simultaneous electrochemical determination of morphine and methadone by using CMK-5 mesoporous carbon and multivariate calibration |
| title_full | Simultaneous electrochemical determination of morphine and methadone by using CMK-5 mesoporous carbon and multivariate calibration |
| title_fullStr | Simultaneous electrochemical determination of morphine and methadone by using CMK-5 mesoporous carbon and multivariate calibration |
| title_full_unstemmed | Simultaneous electrochemical determination of morphine and methadone by using CMK-5 mesoporous carbon and multivariate calibration |
| title_short | Simultaneous electrochemical determination of morphine and methadone by using CMK-5 mesoporous carbon and multivariate calibration |
| title_sort | simultaneous electrochemical determination of morphine and methadone by using cmk 5 mesoporous carbon and multivariate calibration |
| url | https://doi.org/10.1038/s41598-022-12506-9 |
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