Functional and Molecular Markers for Hearing Loss and Vertigo Attacks in Meniere’s Disease
Meniere’s disease (MD) is one of the most complicated diseases in the otologic clinic. The complexity of MD is partially due to the multifactorial etiological mechanisms and the heterogenous symptoms, including episodic vertigo, hearing loss, aural fullness and tinnitus. As a result, the diagnosis o...
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| Format: | Article |
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MDPI AG
2023-01-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/3/2504 |
| _version_ | 1797624366332116992 |
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| author | Chao-Hui Yang Ming-Yu Yang Chung-Feng Hwang Kuang-Hsu Lien |
| author_facet | Chao-Hui Yang Ming-Yu Yang Chung-Feng Hwang Kuang-Hsu Lien |
| author_sort | Chao-Hui Yang |
| collection | DOAJ |
| description | Meniere’s disease (MD) is one of the most complicated diseases in the otologic clinic. The complexity of MD is partially due to the multifactorial etiological mechanisms and the heterogenous symptoms, including episodic vertigo, hearing loss, aural fullness and tinnitus. As a result, the diagnosis of MD and differentiating MD from other diseases with similar symptoms, such as vestibular migraine (VM), is challenging. In addition, it is difficult to predict the progression of hearing loss and the frequency of vertigo attacks. Detailed studies have revealed that functional markers, such as pure tone audiometry (PTA), electrocochleography (ECochG), vestibular evoked myogenic potential (VEMP), caloric test, video head impulse test (vHIT) and magnetic resonance imaging (MRI) could help to evaluate MD with different hearing levels and frequency of vertigo attacks. Investigations of molecular markers such as autoimmunity, inflammation, protein signatures, vasopressin and circadian clock genes in MD are still underway. This review will summarize these functional and molecular markers, address how these markers are associated with hearing loss and vertigo attacks in MD, and analyze the results of the markers between MD and VM. |
| first_indexed | 2024-03-11T09:41:22Z |
| format | Article |
| id | doaj.art-ebed7421247b42189d63ffe75bfedca6 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T09:41:22Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-ebed7421247b42189d63ffe75bfedca62023-11-16T16:58:14ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-01-01243250410.3390/ijms24032504Functional and Molecular Markers for Hearing Loss and Vertigo Attacks in Meniere’s DiseaseChao-Hui Yang0Ming-Yu Yang1Chung-Feng Hwang2Kuang-Hsu Lien3Department of Otolaryngology-Head & Neck Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, TaiwanDepartment of Otolaryngology-Head & Neck Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, TaiwanDepartment of Otolaryngology-Head & Neck Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, TaiwanGraduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, TaiwanMeniere’s disease (MD) is one of the most complicated diseases in the otologic clinic. The complexity of MD is partially due to the multifactorial etiological mechanisms and the heterogenous symptoms, including episodic vertigo, hearing loss, aural fullness and tinnitus. As a result, the diagnosis of MD and differentiating MD from other diseases with similar symptoms, such as vestibular migraine (VM), is challenging. In addition, it is difficult to predict the progression of hearing loss and the frequency of vertigo attacks. Detailed studies have revealed that functional markers, such as pure tone audiometry (PTA), electrocochleography (ECochG), vestibular evoked myogenic potential (VEMP), caloric test, video head impulse test (vHIT) and magnetic resonance imaging (MRI) could help to evaluate MD with different hearing levels and frequency of vertigo attacks. Investigations of molecular markers such as autoimmunity, inflammation, protein signatures, vasopressin and circadian clock genes in MD are still underway. This review will summarize these functional and molecular markers, address how these markers are associated with hearing loss and vertigo attacks in MD, and analyze the results of the markers between MD and VM.https://www.mdpi.com/1422-0067/24/3/2504Meniere’s diseasemarkerspure tone audiometryelectrocochleographyvestibular evoked myogenic potentialcaloric test |
| spellingShingle | Chao-Hui Yang Ming-Yu Yang Chung-Feng Hwang Kuang-Hsu Lien Functional and Molecular Markers for Hearing Loss and Vertigo Attacks in Meniere’s Disease International Journal of Molecular Sciences Meniere’s disease markers pure tone audiometry electrocochleography vestibular evoked myogenic potential caloric test |
| title | Functional and Molecular Markers for Hearing Loss and Vertigo Attacks in Meniere’s Disease |
| title_full | Functional and Molecular Markers for Hearing Loss and Vertigo Attacks in Meniere’s Disease |
| title_fullStr | Functional and Molecular Markers for Hearing Loss and Vertigo Attacks in Meniere’s Disease |
| title_full_unstemmed | Functional and Molecular Markers for Hearing Loss and Vertigo Attacks in Meniere’s Disease |
| title_short | Functional and Molecular Markers for Hearing Loss and Vertigo Attacks in Meniere’s Disease |
| title_sort | functional and molecular markers for hearing loss and vertigo attacks in meniere s disease |
| topic | Meniere’s disease markers pure tone audiometry electrocochleography vestibular evoked myogenic potential caloric test |
| url | https://www.mdpi.com/1422-0067/24/3/2504 |
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