A Computational Inter-Species Study on Safrole Phase I Metabolism-Dependent Bioactivation: A Mechanistic Insight into the Study of Possible Differences among Species

A Computational Inter-Species Study on Safrole Phase I Metabolism-Dependent Bioactivation: A Mechanistic Insight into the Study of Possible Differences among Species

Safrole, a 162.2 Da natural compound belonging to the alkenylbenzenes class, is classified as a possible carcinogen to humans by IARC (group IIB) and has proven to be genotoxic and carcinogenic to rodents. Despite its use as a food or feed additive, it is forbidden in many countries due to its docum...

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Bibliographic Details
Main Authors: Lorenzo Pedroni, Jochem Louisse, Ans Punt, Jean Lou C. M. Dorne, Chiara Dall’Asta, Luca Dellafiora
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Toxins
Subjects:
alkenylbenzenes
cytochrome P450
safrole
estragole
CYP1A2
CYP2A6
Online Access:https://www.mdpi.com/2072-6651/15/2/94

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