Hindlimb Immobilization Increases IL-1β and Cdkn2a Expression in Skeletal Muscle Fibro-Adipogenic Progenitor Cells: A Link Between Senescence and Muscle Disuse Atrophy

Hindlimb Immobilization Increases IL-1β and Cdkn2a Expression in Skeletal Muscle Fibro-Adipogenic Progenitor Cells: A Link Between Senescence and Muscle Disuse Atrophy

Loss of muscle mass and strength contributes to decreased independence and an increased risk for morbidity and mortality. A better understanding of the cellular and molecular mechanisms underlying muscle atrophy therefore has significant clinical and therapeutic implications. Fibro-adipogenic progen...

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Bibliographic Details
Main Authors: Emily Parker, Andrew Khayrullin, Andrew Kent, Bharati Mendhe, Khairat Bahgat Youssef El Baradie, Kanglun Yu, Jeanene Pihkala, Yutao Liu, Meghan McGee-Lawrence, Maribeth Johnson, Jie Chen, Mark Hamrick
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
atrophy
SASP
RNA-seq
disuse
progenitor cell
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.790437/full

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