Treatment of cardiac arrhythmias in a mouse model of Rett syndrome with Na+-channel-blocking antiepileptic drugs
One quarter of deaths associated with Rett syndrome (RTT), an X-linked neurodevelopmental disorder, are sudden and unexpected. RTT is associated with prolonged QTc interval (LQT), and LQT-associated cardiac arrhythmias are a potential cause of unexpected death. The standard of care for LQT in RTT is...
Main Authors: | José A. Herrera, Christopher S. Ward, Meagan R. Pitcher, Alan K. Percy, Steven Skinner, Walter E. Kaufmann, Daniel G. Glaze, Xander H. T. Wehrens, Jeffrey L. Neul |
---|---|
Format: | Article |
Language: | English |
Published: |
The Company of Biologists
2015-04-01
|
Series: | Disease Models & Mechanisms |
Subjects: | |
Online Access: | http://dmm.biologists.org/content/8/4/363 |
Similar Items
-
Rett syndrome in Ireland: a demographic study
by: Komal Zade, et al.
Published: (2024-01-01) -
Rett Syndrome and the Role of MECP2: Signaling to Clinical Trials
by: Adele Gaspar Lopes, et al.
Published: (2024-01-01) -
Mechanism and consequence of abnormal calcium homeostasis in Rett syndrome astrocytes
by: Qiping Dong, et al.
Published: (2018-03-01) -
Manipulations of MeCP2 in glutamatergic neurons highlight their contributions to Rett and other neurological disorders
by: Xiangling Meng, et al.
Published: (2016-06-01) -
Advances in the pathogenesis of Rett syndrome using cell models
by: Sijia Lu, et al.
Published: (2022-12-01)