Effect of the Helping Babies Breathe Program on Newborn Outcomes: Systematic Review and Meta-Analysis
<i>Background and objectives:</i> In low- and middle-income countries, the leading cause of neonatal mortality is perinatal asphyxia. Training in neonatal resuscitation has been shown to decrease this cause of mortality. The program “Helping Babies Breathe” (HBB) is a program to teach ba...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/58/11/1567 |
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| author | Sergio Agudelo-Pérez Annie Cifuentes-Serrano Paula Ávila-Celis Henry Oliveros |
| author_facet | Sergio Agudelo-Pérez Annie Cifuentes-Serrano Paula Ávila-Celis Henry Oliveros |
| author_sort | Sergio Agudelo-Pérez |
| collection | DOAJ |
| description | <i>Background and objectives:</i> In low- and middle-income countries, the leading cause of neonatal mortality is perinatal asphyxia. Training in neonatal resuscitation has been shown to decrease this cause of mortality. The program “Helping Babies Breathe” (HBB) is a program to teach basic neonatal resuscitation focused on countries and areas with limited economic resources. The aim of the study was to determine the effect of the implementation of the HBB program on newborn outcomes: mortality and morbidity. <i>Material and Methods:</i> A systematic review was carried out on observational studies and clinical trials that reported the effect of the implementation in low- and middle-income countries of the HBB program on neonatal mortality and morbidity. We carried out a meta-analysis of the extracted data. Random-effect models were used to evaluate heterogeneity, using the Cochrane Q and I2 tests, and stratified analyses were performed by age and type of outcome to determine the sources of heterogeneity. <i>Results:</i> Eleven studies were identified. The implementation of the program includes educational strategies focused on the training of doctors, nurses, midwives, and students of health professions. The poled results showed a decrease in overall mortality (OR 0.67; 95% CI 0.57, 0.80), intrapartum stillbirth mortality (OR 0.62; 95% CI 0.51, 0.75), and first-day mortality (OR 0.70; 95% IC 0.64, 0.77). High heterogeneity was found, which was partly explained by differences in the gestational age of the participants. <i>Conclusions:</i> The implementation of the program HBB in low- and medium-income countries has a significant impact on reducing early neonatal mortality. |
| first_indexed | 2024-03-09T18:52:22Z |
| format | Article |
| id | doaj.art-ebf47653b8f34e21a216997f43dc0f23 |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-09T18:52:22Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-ebf47653b8f34e21a216997f43dc0f232023-11-24T05:46:55ZengMDPI AGMedicina1010-660X1648-91442022-10-015811156710.3390/medicina58111567Effect of the Helping Babies Breathe Program on Newborn Outcomes: Systematic Review and Meta-AnalysisSergio Agudelo-Pérez0Annie Cifuentes-Serrano1Paula Ávila-Celis2Henry Oliveros3School of Medicine, Universidad de La Sabana, Campus Puente del Común, Km. 7, Autopista Norte de Bogotá, Chía 250001, ColombiaSchool of Medicine, Universidad de La Sabana, Campus Puente del Común, Km. 7, Autopista Norte de Bogotá, Chía 250001, ColombiaSchool of Medicine, Universidad de La Sabana, Campus Puente del Común, Km. 7, Autopista Norte de Bogotá, Chía 250001, ColombiaSchool of Medicine, Universidad de La Sabana, Campus Puente del Común, Km. 7, Autopista Norte de Bogotá, Chía 250001, Colombia<i>Background and objectives:</i> In low- and middle-income countries, the leading cause of neonatal mortality is perinatal asphyxia. Training in neonatal resuscitation has been shown to decrease this cause of mortality. The program “Helping Babies Breathe” (HBB) is a program to teach basic neonatal resuscitation focused on countries and areas with limited economic resources. The aim of the study was to determine the effect of the implementation of the HBB program on newborn outcomes: mortality and morbidity. <i>Material and Methods:</i> A systematic review was carried out on observational studies and clinical trials that reported the effect of the implementation in low- and middle-income countries of the HBB program on neonatal mortality and morbidity. We carried out a meta-analysis of the extracted data. Random-effect models were used to evaluate heterogeneity, using the Cochrane Q and I2 tests, and stratified analyses were performed by age and type of outcome to determine the sources of heterogeneity. <i>Results:</i> Eleven studies were identified. The implementation of the program includes educational strategies focused on the training of doctors, nurses, midwives, and students of health professions. The poled results showed a decrease in overall mortality (OR 0.67; 95% CI 0.57, 0.80), intrapartum stillbirth mortality (OR 0.62; 95% CI 0.51, 0.75), and first-day mortality (OR 0.70; 95% IC 0.64, 0.77). High heterogeneity was found, which was partly explained by differences in the gestational age of the participants. <i>Conclusions:</i> The implementation of the program HBB in low- and medium-income countries has a significant impact on reducing early neonatal mortality.https://www.mdpi.com/1648-9144/58/11/1567Helping Babies Breath ProgramBasic Newborn Resuscitationinfant mortalityasphyxia neonatorumcritical care outcomes |
| spellingShingle | Sergio Agudelo-Pérez Annie Cifuentes-Serrano Paula Ávila-Celis Henry Oliveros Effect of the Helping Babies Breathe Program on Newborn Outcomes: Systematic Review and Meta-Analysis Medicina Helping Babies Breath Program Basic Newborn Resuscitation infant mortality asphyxia neonatorum critical care outcomes |
| title | Effect of the Helping Babies Breathe Program on Newborn Outcomes: Systematic Review and Meta-Analysis |
| title_full | Effect of the Helping Babies Breathe Program on Newborn Outcomes: Systematic Review and Meta-Analysis |
| title_fullStr | Effect of the Helping Babies Breathe Program on Newborn Outcomes: Systematic Review and Meta-Analysis |
| title_full_unstemmed | Effect of the Helping Babies Breathe Program on Newborn Outcomes: Systematic Review and Meta-Analysis |
| title_short | Effect of the Helping Babies Breathe Program on Newborn Outcomes: Systematic Review and Meta-Analysis |
| title_sort | effect of the helping babies breathe program on newborn outcomes systematic review and meta analysis |
| topic | Helping Babies Breath Program Basic Newborn Resuscitation infant mortality asphyxia neonatorum critical care outcomes |
| url | https://www.mdpi.com/1648-9144/58/11/1567 |
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