Effect of Prenatal Citalopram Exposure on Motor and Cognitive Functions of Rats
Aim: Physicians mostly prescribe selective serotonin reuptake inhibitors in the treat-ment of depression in pregnancy. However, there is little information on teratogenic effects of selective serotonin reuptake inhibitors. This study aims to investigate the ef-fects of prenatal exposure to citalopra...
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| Format: | Article |
| Language: | English |
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Alanya Alaaddin Keykubat University
2019-10-01
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| Series: | Acta Medica Alanya |
| Subjects: | |
| Online Access: | https://dergipark.org.tr/en/pub/medalanya/issue/49795/556757?publisher=alku |
| _version_ | 1797906488917753856 |
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| author | Ayşenur Zai̇moğlu Bahar Akyüz S. Sırrı Bi̇lge |
| author_facet | Ayşenur Zai̇moğlu Bahar Akyüz S. Sırrı Bi̇lge |
| author_sort | Ayşenur Zai̇moğlu |
| collection | DOAJ |
| description | Aim: Physicians mostly prescribe selective serotonin reuptake inhibitors in the treat-ment of depression in pregnancy. However, there is little information on teratogenic effects of selective serotonin reuptake inhibitors. This study aims to investigate the ef-fects of prenatal exposure to citalopram, one of the most prescribed antidepressants, on developmental characteristics, reflex and motor functions of rat pups. Materials and Methods: 12-14 weeks old, pregnant Sprague-Dawley rats were used in the experiments. Rats were divided into 3 groups and separated into individual cag-es. When treatment groups received 5 and 20 mg/kg/d citalopram by orogastric ga-vage from gestational days 1 to 18, control group received the same amount of saline (2 ml/kg/d). After birth duration of gestation, number of live and dead pups and gross malformation are evaluated. Eye opening, pinna detachment, incisor eruption, the development of fur and weight gain were monitored as developmental parameters. Markers for reflex development were identified as righting reflex, negative geotaxis and grip response. Motor developments and cognitive functions were established with locomotor activity test, T-maze, holeboard, Y-maze and passive avoidance test. Results: Developmental parameters, reflex, motor and cognitive development as-sessments of pups were not significantly different in treatment groups compared to control group. Conclusion: The results of the study show that prenatal exposure to citalopram has no effect on motor and cognitive functions of rat offspring. |
| first_indexed | 2024-04-10T10:21:40Z |
| format | Article |
| id | doaj.art-ebf4d15843f4418aad56a61c3fb2f6a8 |
| institution | Directory Open Access Journal |
| issn | 2587-0319 |
| language | English |
| last_indexed | 2024-04-10T10:21:40Z |
| publishDate | 2019-10-01 |
| publisher | Alanya Alaaddin Keykubat University |
| record_format | Article |
| series | Acta Medica Alanya |
| spelling | doaj.art-ebf4d15843f4418aad56a61c3fb2f6a82023-02-15T16:21:36ZengAlanya Alaaddin Keykubat UniversityActa Medica Alanya2587-03192019-10-013321321910.30565/medalanya.556757727Effect of Prenatal Citalopram Exposure on Motor and Cognitive Functions of RatsAyşenur Zai̇moğlu0Bahar Akyüz1S. Sırrı Bi̇lge2ONDOKUZ MAYIS UNIVERSITYONDOKUZ MAYIS UNIVERSITYONDOKUZ MAYIS UNIVERSITYAim: Physicians mostly prescribe selective serotonin reuptake inhibitors in the treat-ment of depression in pregnancy. However, there is little information on teratogenic effects of selective serotonin reuptake inhibitors. This study aims to investigate the ef-fects of prenatal exposure to citalopram, one of the most prescribed antidepressants, on developmental characteristics, reflex and motor functions of rat pups. Materials and Methods: 12-14 weeks old, pregnant Sprague-Dawley rats were used in the experiments. Rats were divided into 3 groups and separated into individual cag-es. When treatment groups received 5 and 20 mg/kg/d citalopram by orogastric ga-vage from gestational days 1 to 18, control group received the same amount of saline (2 ml/kg/d). After birth duration of gestation, number of live and dead pups and gross malformation are evaluated. Eye opening, pinna detachment, incisor eruption, the development of fur and weight gain were monitored as developmental parameters. Markers for reflex development were identified as righting reflex, negative geotaxis and grip response. Motor developments and cognitive functions were established with locomotor activity test, T-maze, holeboard, Y-maze and passive avoidance test. Results: Developmental parameters, reflex, motor and cognitive development as-sessments of pups were not significantly different in treatment groups compared to control group. Conclusion: The results of the study show that prenatal exposure to citalopram has no effect on motor and cognitive functions of rat offspring.https://dergipark.org.tr/en/pub/medalanya/issue/49795/556757?publisher=alkudepresyonseçici seratonin geri alım inhibitörlerisıçansitalopramteratojenitedepressionselective serotonin re-uptake inhibitorsratcitalopramteratogenity |
| spellingShingle | Ayşenur Zai̇moğlu Bahar Akyüz S. Sırrı Bi̇lge Effect of Prenatal Citalopram Exposure on Motor and Cognitive Functions of Rats Acta Medica Alanya depresyon seçici seratonin geri alım inhibitörleri sıçan sitalopram teratojenite depression selective serotonin re-uptake inhibitors rat citalopram teratogenity |
| title | Effect of Prenatal Citalopram Exposure on Motor and Cognitive Functions of Rats |
| title_full | Effect of Prenatal Citalopram Exposure on Motor and Cognitive Functions of Rats |
| title_fullStr | Effect of Prenatal Citalopram Exposure on Motor and Cognitive Functions of Rats |
| title_full_unstemmed | Effect of Prenatal Citalopram Exposure on Motor and Cognitive Functions of Rats |
| title_short | Effect of Prenatal Citalopram Exposure on Motor and Cognitive Functions of Rats |
| title_sort | effect of prenatal citalopram exposure on motor and cognitive functions of rats |
| topic | depresyon seçici seratonin geri alım inhibitörleri sıçan sitalopram teratojenite depression selective serotonin re-uptake inhibitors rat citalopram teratogenity |
| url | https://dergipark.org.tr/en/pub/medalanya/issue/49795/556757?publisher=alku |
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