Microbial involvement in Alzheimer disease development and progression
Abstract Alzheimer disease (AD) is the most prominent form of dementia and the 5th leading cause of death in individuals over 65. AD is a complex disease stemming from genetic, environmental, and lifestyle factors. It is known that AD patients have increased levels of senile plaques, neurofibrillary...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-07-01
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| Series: | Molecular Neurodegeneration |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13024-020-00378-4 |
| _version_ | 1818296090813792256 |
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| author | Hannah R. Bulgart Evan W. Neczypor Loren E. Wold Amy R. Mackos |
| author_facet | Hannah R. Bulgart Evan W. Neczypor Loren E. Wold Amy R. Mackos |
| author_sort | Hannah R. Bulgart |
| collection | DOAJ |
| description | Abstract Alzheimer disease (AD) is the most prominent form of dementia and the 5th leading cause of death in individuals over 65. AD is a complex disease stemming from genetic, environmental, and lifestyle factors. It is known that AD patients have increased levels of senile plaques, neurofibrillary tangles, and neuroinflammation; however, the mechanism(s) by which the plaques, tangles, and neuroinflammation manifest remain elusive. A recent hypothesis has emerged that resident bacterial populations contribute to the development and progression of AD by contributing to neuroinflammation, senile plaque formation, and potentially neurofibrillary tangle accumulation (Fig. 1). This review will highlight recent studies involved in elucidating microbial involvement in AD development and progression. |
| first_indexed | 2024-12-13T03:58:01Z |
| format | Article |
| id | doaj.art-ebf4e9b08c314e6d838ccf6815adc831 |
| institution | Directory Open Access Journal |
| issn | 1750-1326 |
| language | English |
| last_indexed | 2024-12-13T03:58:01Z |
| publishDate | 2020-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Neurodegeneration |
| spelling | doaj.art-ebf4e9b08c314e6d838ccf6815adc8312022-12-22T00:00:35ZengBMCMolecular Neurodegeneration1750-13262020-07-0115111210.1186/s13024-020-00378-4Microbial involvement in Alzheimer disease development and progressionHannah R. Bulgart0Evan W. Neczypor1Loren E. Wold2Amy R. Mackos3Biomedical Sciences Graduate Program, College of Medicine, The Ohio State UniversityDorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State UniversityDorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State UniversityCollege of Nursing, The Ohio State UniversityAbstract Alzheimer disease (AD) is the most prominent form of dementia and the 5th leading cause of death in individuals over 65. AD is a complex disease stemming from genetic, environmental, and lifestyle factors. It is known that AD patients have increased levels of senile plaques, neurofibrillary tangles, and neuroinflammation; however, the mechanism(s) by which the plaques, tangles, and neuroinflammation manifest remain elusive. A recent hypothesis has emerged that resident bacterial populations contribute to the development and progression of AD by contributing to neuroinflammation, senile plaque formation, and potentially neurofibrillary tangle accumulation (Fig. 1). This review will highlight recent studies involved in elucidating microbial involvement in AD development and progression.http://link.springer.com/article/10.1186/s13024-020-00378-4Gut microbiotaOral microbiotaAlzheimer disease |
| spellingShingle | Hannah R. Bulgart Evan W. Neczypor Loren E. Wold Amy R. Mackos Microbial involvement in Alzheimer disease development and progression Molecular Neurodegeneration Gut microbiota Oral microbiota Alzheimer disease |
| title | Microbial involvement in Alzheimer disease development and progression |
| title_full | Microbial involvement in Alzheimer disease development and progression |
| title_fullStr | Microbial involvement in Alzheimer disease development and progression |
| title_full_unstemmed | Microbial involvement in Alzheimer disease development and progression |
| title_short | Microbial involvement in Alzheimer disease development and progression |
| title_sort | microbial involvement in alzheimer disease development and progression |
| topic | Gut microbiota Oral microbiota Alzheimer disease |
| url | http://link.springer.com/article/10.1186/s13024-020-00378-4 |
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