Pre-transplant hepatic steatosis (fatty liver) is associated with chronic graft-vs-host disease but not mortality.
Allogeneic-HCT (allo-HCT), while potentially curative, can result in significant complications including graft versus host disease (GVHD). Prior studies suggest that metabolic syndrome may be one risk factor for GVHD. We hypothesized that hepatic steatosis on pre-HCT computed tomography (CT) scans m...
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2020-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0238824 |
| _version_ | 1818916865991245824 |
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| author | Ko Maung Sendhilnathan Ramalingam Mohammad Chaudhry Yi Ren Sin-Ho Jung Kristi Romero Kelly Corbet Nelson J Chao Taewoong Choi Anna Mae Diehl Louis Diehl Cristina Gasparetto Mitchell Horwitz Gwynn Douglas Long Richard D Lopez David A Rizzieri Stefanie Sarantopoulos Keith M Sullivan Mustafa R Bashir Anthony D Sung |
| author_facet | Ko Maung Sendhilnathan Ramalingam Mohammad Chaudhry Yi Ren Sin-Ho Jung Kristi Romero Kelly Corbet Nelson J Chao Taewoong Choi Anna Mae Diehl Louis Diehl Cristina Gasparetto Mitchell Horwitz Gwynn Douglas Long Richard D Lopez David A Rizzieri Stefanie Sarantopoulos Keith M Sullivan Mustafa R Bashir Anthony D Sung |
| author_sort | Ko Maung |
| collection | DOAJ |
| description | Allogeneic-HCT (allo-HCT), while potentially curative, can result in significant complications including graft versus host disease (GVHD). Prior studies suggest that metabolic syndrome may be one risk factor for GVHD. We hypothesized that hepatic steatosis on pre-HCT computed tomography (CT) scans may be a marker for development of GVHD and poor outcomes in allo-HCT. In this retrospective study, we reviewed the pre-HCT CT scans and transplant outcome data of patients who underwent allo-HCT at Duke University Medical Center from 2009 to 2017. The presence of steatosis was confirmed using CT attenuation measurements. We then assessed the association between pre-HCT hepatic steatosis and HCT-related outcomes including GVHD. 80 patients who had pre-HCT CT scans were included in the study. Pre-transplant hepatic steatosis was associated with the development of chronic GVHD (OR 4.2, p = 0.02), but was not associated with acute GVHD (OR 1.3, p = 0.7), non-relapse mortality (p = 0.81) or overall survival (p = 0.74). Based on this single center retrospective study, pre-transplant hepatic steatosis is associated with development of chronic GVHD. Further, prospective study with other imaging modalities including non-contrasted CT scans is needed to determine if this association is reproducible. |
| first_indexed | 2024-12-20T00:24:58Z |
| format | Article |
| id | doaj.art-ebf9b78ac6c540739ed63938ecd872d4 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-20T00:24:58Z |
| publishDate | 2020-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-ebf9b78ac6c540739ed63938ecd872d42022-12-21T20:00:06ZengPublic Library of Science (PLoS)PLoS ONE1932-62032020-01-01159e023882410.1371/journal.pone.0238824Pre-transplant hepatic steatosis (fatty liver) is associated with chronic graft-vs-host disease but not mortality.Ko MaungSendhilnathan RamalingamMohammad ChaudhryYi RenSin-Ho JungKristi RomeroKelly CorbetNelson J ChaoTaewoong ChoiAnna Mae DiehlLouis DiehlCristina GasparettoMitchell HorwitzGwynn Douglas LongRichard D LopezDavid A RizzieriStefanie SarantopoulosKeith M SullivanMustafa R BashirAnthony D SungAllogeneic-HCT (allo-HCT), while potentially curative, can result in significant complications including graft versus host disease (GVHD). Prior studies suggest that metabolic syndrome may be one risk factor for GVHD. We hypothesized that hepatic steatosis on pre-HCT computed tomography (CT) scans may be a marker for development of GVHD and poor outcomes in allo-HCT. In this retrospective study, we reviewed the pre-HCT CT scans and transplant outcome data of patients who underwent allo-HCT at Duke University Medical Center from 2009 to 2017. The presence of steatosis was confirmed using CT attenuation measurements. We then assessed the association between pre-HCT hepatic steatosis and HCT-related outcomes including GVHD. 80 patients who had pre-HCT CT scans were included in the study. Pre-transplant hepatic steatosis was associated with the development of chronic GVHD (OR 4.2, p = 0.02), but was not associated with acute GVHD (OR 1.3, p = 0.7), non-relapse mortality (p = 0.81) or overall survival (p = 0.74). Based on this single center retrospective study, pre-transplant hepatic steatosis is associated with development of chronic GVHD. Further, prospective study with other imaging modalities including non-contrasted CT scans is needed to determine if this association is reproducible.https://doi.org/10.1371/journal.pone.0238824 |
| spellingShingle | Ko Maung Sendhilnathan Ramalingam Mohammad Chaudhry Yi Ren Sin-Ho Jung Kristi Romero Kelly Corbet Nelson J Chao Taewoong Choi Anna Mae Diehl Louis Diehl Cristina Gasparetto Mitchell Horwitz Gwynn Douglas Long Richard D Lopez David A Rizzieri Stefanie Sarantopoulos Keith M Sullivan Mustafa R Bashir Anthony D Sung Pre-transplant hepatic steatosis (fatty liver) is associated with chronic graft-vs-host disease but not mortality. PLoS ONE |
| title | Pre-transplant hepatic steatosis (fatty liver) is associated with chronic graft-vs-host disease but not mortality. |
| title_full | Pre-transplant hepatic steatosis (fatty liver) is associated with chronic graft-vs-host disease but not mortality. |
| title_fullStr | Pre-transplant hepatic steatosis (fatty liver) is associated with chronic graft-vs-host disease but not mortality. |
| title_full_unstemmed | Pre-transplant hepatic steatosis (fatty liver) is associated with chronic graft-vs-host disease but not mortality. |
| title_short | Pre-transplant hepatic steatosis (fatty liver) is associated with chronic graft-vs-host disease but not mortality. |
| title_sort | pre transplant hepatic steatosis fatty liver is associated with chronic graft vs host disease but not mortality |
| url | https://doi.org/10.1371/journal.pone.0238824 |
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