Cytochrome <i>c</i><sub>M</sub> Is Probably a Membrane Protein Similar to the C Subunit of the Bacterial Nitric Oxide Reductase
Cytochrome <i>c</i><sub>M</sub> was first described in 1994 and its sequence has been found in the genome of manifold cyanobacterial species ever since. Numerous studies have been carried out with the purpose of determining its function, but none of them has given place to co...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-10-01
|
| Series: | Applied Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3417/11/20/9396 |
| _version_ | 1797515462209175552 |
|---|---|
| author | Tomás Rodríguez-Gil Alejandro Torrado Macarena Iniesta-Pallarés Consolación Álvarez Vicente Mariscal Fernando P. Molina-Heredia |
| author_facet | Tomás Rodríguez-Gil Alejandro Torrado Macarena Iniesta-Pallarés Consolación Álvarez Vicente Mariscal Fernando P. Molina-Heredia |
| author_sort | Tomás Rodríguez-Gil |
| collection | DOAJ |
| description | Cytochrome <i>c</i><sub>M</sub> was first described in 1994 and its sequence has been found in the genome of manifold cyanobacterial species ever since. Numerous studies have been carried out with the purpose of determining its function, but none of them has given place to conclusive results so far. Many of these studies are based on the assumption that cytochrome <i>c</i><sub>M</sub> is a soluble protein located in the thylakoid lumen of cyanobacteria. In this work, we have reevaluated the sequence of cytochrome <i>c</i><sub>M</sub>, with our results showing that its most probable 3D structure is strongly similar to that of the C subunit of the bacterial nitric oxide reductase. The potential presence of an α-helix tail, which could locate this protein in the thylakoid membrane, further supports this hypothesis, thus providing a new, unexpected role for this redox protein. |
| first_indexed | 2024-03-10T06:45:49Z |
| format | Article |
| id | doaj.art-ebfa37c9f2b343d0b8e62b6b2e76d681 |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-10T06:45:49Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-ebfa37c9f2b343d0b8e62b6b2e76d6812023-11-22T17:17:53ZengMDPI AGApplied Sciences2076-34172021-10-011120939610.3390/app11209396Cytochrome <i>c</i><sub>M</sub> Is Probably a Membrane Protein Similar to the C Subunit of the Bacterial Nitric Oxide ReductaseTomás Rodríguez-Gil0Alejandro Torrado1Macarena Iniesta-Pallarés2Consolación Álvarez3Vicente Mariscal4Fernando P. Molina-Heredia5Instituto de Bioquímica Vegetal y Fotosíntesis, Universidad de Sevilla and CSIC, C. Américo Vespucio 49, 41092 Seville, SpainInstituto de Bioquímica Vegetal y Fotosíntesis, Universidad de Sevilla and CSIC, C. Américo Vespucio 49, 41092 Seville, SpainInstituto de Bioquímica Vegetal y Fotosíntesis, Universidad de Sevilla and CSIC, C. Américo Vespucio 49, 41092 Seville, SpainInstituto de Bioquímica Vegetal y Fotosíntesis, Universidad de Sevilla and CSIC, C. Américo Vespucio 49, 41092 Seville, SpainInstituto de Bioquímica Vegetal y Fotosíntesis, Universidad de Sevilla and CSIC, C. Américo Vespucio 49, 41092 Seville, SpainInstituto de Bioquímica Vegetal y Fotosíntesis, Universidad de Sevilla and CSIC, C. Américo Vespucio 49, 41092 Seville, SpainCytochrome <i>c</i><sub>M</sub> was first described in 1994 and its sequence has been found in the genome of manifold cyanobacterial species ever since. Numerous studies have been carried out with the purpose of determining its function, but none of them has given place to conclusive results so far. Many of these studies are based on the assumption that cytochrome <i>c</i><sub>M</sub> is a soluble protein located in the thylakoid lumen of cyanobacteria. In this work, we have reevaluated the sequence of cytochrome <i>c</i><sub>M</sub>, with our results showing that its most probable 3D structure is strongly similar to that of the C subunit of the bacterial nitric oxide reductase. The potential presence of an α-helix tail, which could locate this protein in the thylakoid membrane, further supports this hypothesis, thus providing a new, unexpected role for this redox protein.https://www.mdpi.com/2076-3417/11/20/9396cyanobacteriacytochrome <i>c</i><sub>M</sub>NorCnitric oxide reductase |
| spellingShingle | Tomás Rodríguez-Gil Alejandro Torrado Macarena Iniesta-Pallarés Consolación Álvarez Vicente Mariscal Fernando P. Molina-Heredia Cytochrome <i>c</i><sub>M</sub> Is Probably a Membrane Protein Similar to the C Subunit of the Bacterial Nitric Oxide Reductase Applied Sciences cyanobacteria cytochrome <i>c</i><sub>M</sub> NorC nitric oxide reductase |
| title | Cytochrome <i>c</i><sub>M</sub> Is Probably a Membrane Protein Similar to the C Subunit of the Bacterial Nitric Oxide Reductase |
| title_full | Cytochrome <i>c</i><sub>M</sub> Is Probably a Membrane Protein Similar to the C Subunit of the Bacterial Nitric Oxide Reductase |
| title_fullStr | Cytochrome <i>c</i><sub>M</sub> Is Probably a Membrane Protein Similar to the C Subunit of the Bacterial Nitric Oxide Reductase |
| title_full_unstemmed | Cytochrome <i>c</i><sub>M</sub> Is Probably a Membrane Protein Similar to the C Subunit of the Bacterial Nitric Oxide Reductase |
| title_short | Cytochrome <i>c</i><sub>M</sub> Is Probably a Membrane Protein Similar to the C Subunit of the Bacterial Nitric Oxide Reductase |
| title_sort | cytochrome i c i sub m sub is probably a membrane protein similar to the c subunit of the bacterial nitric oxide reductase |
| topic | cyanobacteria cytochrome <i>c</i><sub>M</sub> NorC nitric oxide reductase |
| url | https://www.mdpi.com/2076-3417/11/20/9396 |
| work_keys_str_mv | AT tomasrodriguezgil cytochromeicisubmsubisprobablyamembraneproteinsimilartothecsubunitofthebacterialnitricoxidereductase AT alejandrotorrado cytochromeicisubmsubisprobablyamembraneproteinsimilartothecsubunitofthebacterialnitricoxidereductase AT macarenainiestapallares cytochromeicisubmsubisprobablyamembraneproteinsimilartothecsubunitofthebacterialnitricoxidereductase AT consolacionalvarez cytochromeicisubmsubisprobablyamembraneproteinsimilartothecsubunitofthebacterialnitricoxidereductase AT vicentemariscal cytochromeicisubmsubisprobablyamembraneproteinsimilartothecsubunitofthebacterialnitricoxidereductase AT fernandopmolinaheredia cytochromeicisubmsubisprobablyamembraneproteinsimilartothecsubunitofthebacterialnitricoxidereductase |