Host metabolomic responses in recurrent P. vivax malaria
Abstract Malaria is the leading parasitic disease worldwide, with P. vivax being a major challenge for its control. Several studies have indicated metabolomics as a promising tool for combating the disease. The study evaluated plasma metabolomic profiles of patients with recurrent and non-recurrent...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-03-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-54231-5 |
| _version_ | 1797233706845339648 |
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| author | Michael N. Yakubu Victor I. Mwangi Rebeca L. A. Netto Maria G. C. Alecrim Jessica R. S. Alves Anne C. G. Almeida Gabriel F. Santos Gesiane S. Lima Lucas S. Machado Hector H. F. Koolen Tiago P. Guimarães Andrea R. Chaves Boniek G. Vaz Wuelton M. Monteiro Fabio T. M. Costa Marcus V. G. Lacerda Luiz G. Gardinassi Gisely C. de Melo |
| author_facet | Michael N. Yakubu Victor I. Mwangi Rebeca L. A. Netto Maria G. C. Alecrim Jessica R. S. Alves Anne C. G. Almeida Gabriel F. Santos Gesiane S. Lima Lucas S. Machado Hector H. F. Koolen Tiago P. Guimarães Andrea R. Chaves Boniek G. Vaz Wuelton M. Monteiro Fabio T. M. Costa Marcus V. G. Lacerda Luiz G. Gardinassi Gisely C. de Melo |
| author_sort | Michael N. Yakubu |
| collection | DOAJ |
| description | Abstract Malaria is the leading parasitic disease worldwide, with P. vivax being a major challenge for its control. Several studies have indicated metabolomics as a promising tool for combating the disease. The study evaluated plasma metabolomic profiles of patients with recurrent and non-recurrent P. vivax malaria in the Brazilian Amazon. Metabolites extracted from the plasma of P. vivax-infected patients were subjected to LC–MS analysis. Untargeted metabolomics was applied to investigate the metabolic profile of the plasma in the two groups. Overall, 51 recurrent and 59 non-recurrent patients were included in the study. Longitudinal metabolomic analysis revealed 52 and 37 significant metabolite features from the recurrent and non-recurrent participants, respectively. Recurrence was associated with disturbances in eicosanoid metabolism. Comparison between groups suggest alterations in vitamin B6 (pyridoxine) metabolism, tyrosine metabolism, 3-oxo-10-octadecatrienoate β-oxidation, and alkaloid biosynthesis II. Integrative network analysis revealed enrichment of other metabolic pathways for the recurrent phenotype, including the butanoate metabolism, aspartate and asparagine metabolism, and N-glycan biosynthesis. The metabolites and metabolic pathways predicted in our study suggest potential biomarkers of recurrence and provide insights into targets for antimalarial development against P. vivax. |
| first_indexed | 2024-04-24T16:20:26Z |
| format | Article |
| id | doaj.art-ebfb6b0aff804efc93980cbaba6c5447 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-24T16:20:26Z |
| publishDate | 2024-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-ebfb6b0aff804efc93980cbaba6c54472024-03-31T11:15:35ZengNature PortfolioScientific Reports2045-23222024-03-0114111310.1038/s41598-024-54231-5Host metabolomic responses in recurrent P. vivax malariaMichael N. Yakubu0Victor I. Mwangi1Rebeca L. A. Netto2Maria G. C. Alecrim3Jessica R. S. Alves4Anne C. G. Almeida5Gabriel F. Santos6Gesiane S. Lima7Lucas S. Machado8Hector H. F. Koolen9Tiago P. Guimarães10Andrea R. Chaves11Boniek G. Vaz12Wuelton M. Monteiro13Fabio T. M. Costa14Marcus V. G. Lacerda15Luiz G. Gardinassi16Gisely C. de Melo17State University of Amazonas (UEA), Manaus, Amazonas, Brazil/Tropical Medicine Foundation-Dr. Heitor Vieira Dourado (FMT-HVD)State University of Amazonas (UEA), Manaus, Amazonas, Brazil/Tropical Medicine Foundation-Dr. Heitor Vieira Dourado (FMT-HVD)State University of Amazonas (UEA), Manaus, Amazonas, Brazil/Tropical Medicine Foundation-Dr. Heitor Vieira Dourado (FMT-HVD)State University of Amazonas (UEA), Manaus, Amazonas, Brazil/Tropical Medicine Foundation-Dr. Heitor Vieira Dourado (FMT-HVD)Institute of Biology, Laboratory of Tropical Diseases-Prof. Dr. Luiz Jacintho da Silva (LDT-LJS), Department of Genetics, Evolution, Microbiology and Immunology, State University of Campinas (UNICAMP)State University of Amazonas (UEA), Manaus, Amazonas, Brazil/Tropical Medicine Foundation-Dr. Heitor Vieira Dourado (FMT-HVD)Chromatography and Mass Spectrometry Laboratory, Institute of Chemistry, Federal University of GoiásChromatography and Mass Spectrometry Laboratory, Institute of Chemistry, Federal University of GoiásChromatography and Mass Spectrometry Laboratory, Institute of Chemistry, Federal University of GoiásState University of Amazonas (UEA), Manaus, Amazonas, Brazil/Tropical Medicine Foundation-Dr. Heitor Vieira Dourado (FMT-HVD)Institute of Tropical Pathology and Public Health, Federal University of GoiásChromatography and Mass Spectrometry Laboratory, Institute of Chemistry, Federal University of GoiásChromatography and Mass Spectrometry Laboratory, Institute of Chemistry, Federal University of GoiásState University of Amazonas (UEA), Manaus, Amazonas, Brazil/Tropical Medicine Foundation-Dr. Heitor Vieira Dourado (FMT-HVD)Institute of Biology, Laboratory of Tropical Diseases-Prof. Dr. Luiz Jacintho da Silva (LDT-LJS), Department of Genetics, Evolution, Microbiology and Immunology, State University of Campinas (UNICAMP)State University of Amazonas (UEA), Manaus, Amazonas, Brazil/Tropical Medicine Foundation-Dr. Heitor Vieira Dourado (FMT-HVD)University of São Paulo, Ribeirão Preto School of Nursing, Department of Maternal and Child Nursing and Public HealthState University of Amazonas (UEA), Manaus, Amazonas, Brazil/Tropical Medicine Foundation-Dr. Heitor Vieira Dourado (FMT-HVD)Abstract Malaria is the leading parasitic disease worldwide, with P. vivax being a major challenge for its control. Several studies have indicated metabolomics as a promising tool for combating the disease. The study evaluated plasma metabolomic profiles of patients with recurrent and non-recurrent P. vivax malaria in the Brazilian Amazon. Metabolites extracted from the plasma of P. vivax-infected patients were subjected to LC–MS analysis. Untargeted metabolomics was applied to investigate the metabolic profile of the plasma in the two groups. Overall, 51 recurrent and 59 non-recurrent patients were included in the study. Longitudinal metabolomic analysis revealed 52 and 37 significant metabolite features from the recurrent and non-recurrent participants, respectively. Recurrence was associated with disturbances in eicosanoid metabolism. Comparison between groups suggest alterations in vitamin B6 (pyridoxine) metabolism, tyrosine metabolism, 3-oxo-10-octadecatrienoate β-oxidation, and alkaloid biosynthesis II. Integrative network analysis revealed enrichment of other metabolic pathways for the recurrent phenotype, including the butanoate metabolism, aspartate and asparagine metabolism, and N-glycan biosynthesis. The metabolites and metabolic pathways predicted in our study suggest potential biomarkers of recurrence and provide insights into targets for antimalarial development against P. vivax.https://doi.org/10.1038/s41598-024-54231-5 |
| spellingShingle | Michael N. Yakubu Victor I. Mwangi Rebeca L. A. Netto Maria G. C. Alecrim Jessica R. S. Alves Anne C. G. Almeida Gabriel F. Santos Gesiane S. Lima Lucas S. Machado Hector H. F. Koolen Tiago P. Guimarães Andrea R. Chaves Boniek G. Vaz Wuelton M. Monteiro Fabio T. M. Costa Marcus V. G. Lacerda Luiz G. Gardinassi Gisely C. de Melo Host metabolomic responses in recurrent P. vivax malaria Scientific Reports |
| title | Host metabolomic responses in recurrent P. vivax malaria |
| title_full | Host metabolomic responses in recurrent P. vivax malaria |
| title_fullStr | Host metabolomic responses in recurrent P. vivax malaria |
| title_full_unstemmed | Host metabolomic responses in recurrent P. vivax malaria |
| title_short | Host metabolomic responses in recurrent P. vivax malaria |
| title_sort | host metabolomic responses in recurrent p vivax malaria |
| url | https://doi.org/10.1038/s41598-024-54231-5 |
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