Adjuvant and neoadjuvant therapy for pancreatic cancer
Abstract. Pancreatic cancer still remains a major cause of cancer-related mortality; however, there is a slight but continuous improvement in survival over the past 2 decades. Progress in chemotherapy has contributed to the survival improvement in patients with any stage of pancreatic cancer. In thi...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Health/LWW
2019-09-01
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| Series: | Journal of Pancreatology |
| Online Access: | http://journals.lww.com/10.1097/JP9.0000000000000028 |
| _version_ | 1818664190419664896 |
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| author | Shimpei Maeda, MD, PhD Michiaki Unno, MD, PhD, FACS Jun Yu, MD, PhD |
| author_facet | Shimpei Maeda, MD, PhD Michiaki Unno, MD, PhD, FACS Jun Yu, MD, PhD |
| author_sort | Shimpei Maeda, MD, PhD |
| collection | DOAJ |
| description | Abstract. Pancreatic cancer still remains a major cause of cancer-related mortality; however, there is a slight but continuous improvement in survival over the past 2 decades. Progress in chemotherapy has contributed to the survival improvement in patients with any stage of pancreatic cancer. In this review, we summarize the currently available evidence regarding adjuvant and neoadjuvant therapy with a focus mainly on randomized controlled trial. The median overall survival in resected pancreatic cancer patients has significantly improved to 22.8 to 54.4 months with the use of adjuvant therapy from 11 to 20.2 months with a strategy of observation only. Recent data from randomized trials support the use of neoadjuvant therapy for patients with resectable or borderline resectable pancreatic cancer. But given a variety of neoadjuvant regimens and different definitions of resectability status, data should be interpreted with caution. Several other trials are ongoing and will provide further evidence. |
| first_indexed | 2024-12-17T05:28:48Z |
| format | Article |
| id | doaj.art-ebfcc4a19e1f48e3b934109823666eaf |
| institution | Directory Open Access Journal |
| issn | 2096-5664 2577-3577 |
| language | English |
| last_indexed | 2024-12-17T05:28:48Z |
| publishDate | 2019-09-01 |
| publisher | Wolters Kluwer Health/LWW |
| record_format | Article |
| series | Journal of Pancreatology |
| spelling | doaj.art-ebfcc4a19e1f48e3b934109823666eaf2022-12-21T22:01:47ZengWolters Kluwer Health/LWWJournal of Pancreatology2096-56642577-35772019-09-012310010610.1097/JP9.0000000000000028201909000-00007Adjuvant and neoadjuvant therapy for pancreatic cancerShimpei Maeda, MD, PhDMichiaki Unno, MD, PhD, FACSJun Yu, MD, PhDAbstract. Pancreatic cancer still remains a major cause of cancer-related mortality; however, there is a slight but continuous improvement in survival over the past 2 decades. Progress in chemotherapy has contributed to the survival improvement in patients with any stage of pancreatic cancer. In this review, we summarize the currently available evidence regarding adjuvant and neoadjuvant therapy with a focus mainly on randomized controlled trial. The median overall survival in resected pancreatic cancer patients has significantly improved to 22.8 to 54.4 months with the use of adjuvant therapy from 11 to 20.2 months with a strategy of observation only. Recent data from randomized trials support the use of neoadjuvant therapy for patients with resectable or borderline resectable pancreatic cancer. But given a variety of neoadjuvant regimens and different definitions of resectability status, data should be interpreted with caution. Several other trials are ongoing and will provide further evidence.http://journals.lww.com/10.1097/JP9.0000000000000028 |
| spellingShingle | Shimpei Maeda, MD, PhD Michiaki Unno, MD, PhD, FACS Jun Yu, MD, PhD Adjuvant and neoadjuvant therapy for pancreatic cancer Journal of Pancreatology |
| title | Adjuvant and neoadjuvant therapy for pancreatic cancer |
| title_full | Adjuvant and neoadjuvant therapy for pancreatic cancer |
| title_fullStr | Adjuvant and neoadjuvant therapy for pancreatic cancer |
| title_full_unstemmed | Adjuvant and neoadjuvant therapy for pancreatic cancer |
| title_short | Adjuvant and neoadjuvant therapy for pancreatic cancer |
| title_sort | adjuvant and neoadjuvant therapy for pancreatic cancer |
| url | http://journals.lww.com/10.1097/JP9.0000000000000028 |
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