Foxp3+ regulatory T cell therapy for tolerance in autoimmunity and solid organ transplantation
Regulatory T cells (Tregs) are critical for tolerance in humans. The exact mechanisms by which the loss of peripheral tolerance leads to the development of autoimmunity and the specific role Tregs play in allograft tolerance are not fully understood; however, this population of T cells presents a un...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1055466/full |
| _version_ | 1811224270829780992 |
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| author | Jes M. Sanders Shareni Jeyamogan James M. Mathew James M. Mathew James M. Mathew Joseph R. Leventhal Joseph R. Leventhal |
| author_facet | Jes M. Sanders Shareni Jeyamogan James M. Mathew James M. Mathew James M. Mathew Joseph R. Leventhal Joseph R. Leventhal |
| author_sort | Jes M. Sanders |
| collection | DOAJ |
| description | Regulatory T cells (Tregs) are critical for tolerance in humans. The exact mechanisms by which the loss of peripheral tolerance leads to the development of autoimmunity and the specific role Tregs play in allograft tolerance are not fully understood; however, this population of T cells presents a unique opportunity in the development of targeted therapeutics. In this review, we discuss the potential roles of Foxp3+ Tregs in the development of tolerance in transplantation and autoimmunity, and the available data regarding their use as a treatment modality. |
| first_indexed | 2024-04-12T08:45:39Z |
| format | Article |
| id | doaj.art-ec00344083ce45d39c32df3b75b2b45c |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-12T08:45:39Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-ec00344083ce45d39c32df3b75b2b45c2022-12-22T03:39:43ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-11-011310.3389/fimmu.2022.10554661055466Foxp3+ regulatory T cell therapy for tolerance in autoimmunity and solid organ transplantationJes M. Sanders0Shareni Jeyamogan1James M. Mathew2James M. Mathew3James M. Mathew4Joseph R. Leventhal5Joseph R. Leventhal6Department of Surgery, Comprehensive Transplant Center Feinberg School of Medicine, Northwestern University, Chicago, IL, United StatesDepartment of Surgery, Comprehensive Transplant Center Feinberg School of Medicine, Northwestern University, Chicago, IL, United StatesDepartment of Surgery, Comprehensive Transplant Center Feinberg School of Medicine, Northwestern University, Chicago, IL, United StatesDepartment of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United StatesSimpson Querrey Institute for BioNanotechnology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United StatesDepartment of Surgery, Comprehensive Transplant Center Feinberg School of Medicine, Northwestern University, Chicago, IL, United StatesSimpson Querrey Institute for BioNanotechnology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United StatesRegulatory T cells (Tregs) are critical for tolerance in humans. The exact mechanisms by which the loss of peripheral tolerance leads to the development of autoimmunity and the specific role Tregs play in allograft tolerance are not fully understood; however, this population of T cells presents a unique opportunity in the development of targeted therapeutics. In this review, we discuss the potential roles of Foxp3+ Tregs in the development of tolerance in transplantation and autoimmunity, and the available data regarding their use as a treatment modality.https://www.frontiersin.org/articles/10.3389/fimmu.2022.1055466/fullsolid organ transplantationallograft toleranceautoimmunityregulatory T cellsantigen-specific regulatory T cellsadoptive cell transfer |
| spellingShingle | Jes M. Sanders Shareni Jeyamogan James M. Mathew James M. Mathew James M. Mathew Joseph R. Leventhal Joseph R. Leventhal Foxp3+ regulatory T cell therapy for tolerance in autoimmunity and solid organ transplantation Frontiers in Immunology solid organ transplantation allograft tolerance autoimmunity regulatory T cells antigen-specific regulatory T cells adoptive cell transfer |
| title | Foxp3+ regulatory T cell therapy for tolerance in autoimmunity and solid organ transplantation |
| title_full | Foxp3+ regulatory T cell therapy for tolerance in autoimmunity and solid organ transplantation |
| title_fullStr | Foxp3+ regulatory T cell therapy for tolerance in autoimmunity and solid organ transplantation |
| title_full_unstemmed | Foxp3+ regulatory T cell therapy for tolerance in autoimmunity and solid organ transplantation |
| title_short | Foxp3+ regulatory T cell therapy for tolerance in autoimmunity and solid organ transplantation |
| title_sort | foxp3 regulatory t cell therapy for tolerance in autoimmunity and solid organ transplantation |
| topic | solid organ transplantation allograft tolerance autoimmunity regulatory T cells antigen-specific regulatory T cells adoptive cell transfer |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1055466/full |
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