Foxp3+ regulatory T cell therapy for tolerance in autoimmunity and solid organ transplantation

Foxp3+ regulatory T cell therapy for tolerance in autoimmunity and solid organ transplantation

Regulatory T cells (Tregs) are critical for tolerance in humans. The exact mechanisms by which the loss of peripheral tolerance leads to the development of autoimmunity and the specific role Tregs play in allograft tolerance are not fully understood; however, this population of T cells presents a un...

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Bibliographic Details
Main Authors: Jes M. Sanders, Shareni Jeyamogan, James M. Mathew, Joseph R. Leventhal
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Immunology
Subjects:
solid organ transplantation
allograft tolerance
autoimmunity
regulatory T cells
antigen-specific regulatory T cells
adoptive cell transfer
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1055466/full

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