Two adolescent cases of early use of Molecular Adsorbent Recirculating System for drug-induced fulminant hepatic failure
Fulminant hepatic failure (FHF) is a rare but fatal disease with a 40%-80% mortality, often requiring liver transplantation, which is hard to perform in children. A therapeutic intervention alternative to liver transplantation is an extracorporeal artificial liver support system. Molecular Adsorbent...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Korean Society of Pediatric Emergency Medicine
2024-01-01
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| Series: | Pediatric Emergency Medicine Journal |
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| Online Access: | http://pemj.org/upload/pdf/pemj-2023-00815.pdf |
| _version_ | 1797354597764825088 |
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| author | Seo Yeon Kim Beom Joon Kim |
| author_facet | Seo Yeon Kim Beom Joon Kim |
| author_sort | Seo Yeon Kim |
| collection | DOAJ |
| description | Fulminant hepatic failure (FHF) is a rare but fatal disease with a 40%-80% mortality, often requiring liver transplantation, which is hard to perform in children. A therapeutic intervention alternative to liver transplantation is an extracorporeal artificial liver support system. Molecular Adsorbent Recirculation Systems® (MARS) has emerged as a bridge therapy for adult FHF, whereas in pediatric FHF, there have been a small number of cases of implementing MARS. Recently, we witnessed the recovery of 2 teenagers with FHFs caused by acetaminophen and a diet aid. Both patients were treated uneventfully, with early use of MARS. These cases suggest that early use of MARS may be a promising therapeutic intervention in pediatric drug-induced FHF. |
| first_indexed | 2024-03-08T13:52:45Z |
| format | Article |
| id | doaj.art-ec009b8259ed42cfb0402a02cce540ae |
| institution | Directory Open Access Journal |
| issn | 2383-4897 2508-5506 |
| language | English |
| last_indexed | 2024-03-08T13:52:45Z |
| publishDate | 2024-01-01 |
| publisher | Korean Society of Pediatric Emergency Medicine |
| record_format | Article |
| series | Pediatric Emergency Medicine Journal |
| spelling | doaj.art-ec009b8259ed42cfb0402a02cce540ae2024-01-16T01:00:43ZengKorean Society of Pediatric Emergency MedicinePediatric Emergency Medicine Journal2383-48972508-55062024-01-01111576110.22470/pemj.2023.00815188Two adolescent cases of early use of Molecular Adsorbent Recirculating System for drug-induced fulminant hepatic failureSeo Yeon Kim0Beom Joon Kim1Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaDepartment of Pediatrics, The Catholic University of Korea, Eunpyeong St. Mary’s Hospital, Seoul, Republic of KoreaFulminant hepatic failure (FHF) is a rare but fatal disease with a 40%-80% mortality, often requiring liver transplantation, which is hard to perform in children. A therapeutic intervention alternative to liver transplantation is an extracorporeal artificial liver support system. Molecular Adsorbent Recirculation Systems® (MARS) has emerged as a bridge therapy for adult FHF, whereas in pediatric FHF, there have been a small number of cases of implementing MARS. Recently, we witnessed the recovery of 2 teenagers with FHFs caused by acetaminophen and a diet aid. Both patients were treated uneventfully, with early use of MARS. These cases suggest that early use of MARS may be a promising therapeutic intervention in pediatric drug-induced FHF.http://pemj.org/upload/pdf/pemj-2023-00815.pdfdrug-related side effects and adverse reactionsliver, artificialliver failure, acuteliver transplantationpediatrics |
| spellingShingle | Seo Yeon Kim Beom Joon Kim Two adolescent cases of early use of Molecular Adsorbent Recirculating System for drug-induced fulminant hepatic failure Pediatric Emergency Medicine Journal drug-related side effects and adverse reactions liver, artificial liver failure, acute liver transplantation pediatrics |
| title | Two adolescent cases of early use of Molecular Adsorbent Recirculating System for drug-induced fulminant hepatic failure |
| title_full | Two adolescent cases of early use of Molecular Adsorbent Recirculating System for drug-induced fulminant hepatic failure |
| title_fullStr | Two adolescent cases of early use of Molecular Adsorbent Recirculating System for drug-induced fulminant hepatic failure |
| title_full_unstemmed | Two adolescent cases of early use of Molecular Adsorbent Recirculating System for drug-induced fulminant hepatic failure |
| title_short | Two adolescent cases of early use of Molecular Adsorbent Recirculating System for drug-induced fulminant hepatic failure |
| title_sort | two adolescent cases of early use of molecular adsorbent recirculating system for drug induced fulminant hepatic failure |
| topic | drug-related side effects and adverse reactions liver, artificial liver failure, acute liver transplantation pediatrics |
| url | http://pemj.org/upload/pdf/pemj-2023-00815.pdf |
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