Novel 7-Chloro-(4-thioalkylquinoline) Derivatives: Synthesis and Antiproliferative Activity through Inducing Apoptosis and DNA/RNA Damage

Novel 7-Chloro-(4-thioalkylquinoline) Derivatives: Synthesis and Antiproliferative Activity through Inducing Apoptosis and DNA/RNA Damage

A series of 78 synthetic 7-chloro-(4-thioalkylquinoline) derivatives were investigated for cytotoxic activity against eight human cancer as well as 4 non-tumor cell lines. The results showed, with some exceptions, that sulfanyl <b>5</b>–<b>40</b> and sulfinyl <b>41</...

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Bibliographic Details
Main Authors: Joyce E. Gutiérrez, Esteban Fernandez-Moreira, Miguel A. Rodríguez, Michael R. Mijares, Juan Bautista De Sanctis, Soňa Gurská, Petr Džubák, Marián Hajdůch, Julia Bruno-Colmenarez, Luis Rojas, Denis Deffieux, Laurent Pouységu, Stéphane Quideau, Jaime Charris, Hegira Ramírez
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Pharmaceuticals
Subjects:
antiproliferative activity
cell cycle
DNA/RNA damage
Sulfanyl-Sulfinyl-Sulfonyl groups
synthesis of 4-thioalkylquinoline
Online Access:https://www.mdpi.com/1424-8247/15/10/1234

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